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B7GJC8

- UPPP_ANOFW

UniProt

B7GJC8 - UPPP_ANOFW

Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Anoxybacillus flavithermus (strain DSM 21510 / WK1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (10 Feb 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciAFLA491915:GHEO-1276-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance proteinUniRule annotation
    Undecaprenyl pyrophosphate phosphataseUniRule annotation
    Gene namesi
    Name:uppPUniRule annotation
    Ordered Locus Names:Aflv_1202
    OrganismiAnoxybacillus flavithermus (strain DSM 21510 / WK1)
    Taxonomic identifieri491915 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeAnoxybacillus
    ProteomesiUP000000742: Chromosome

    Subcellular locationi

    Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 273273Undecaprenyl-diphosphatasePRO_1000197347Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi491915.Aflv_1202.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei3 – 2321HelicalUniRule annotationAdd
    BLAST
    Transmembranei48 – 6821HelicalUniRule annotationAdd
    BLAST
    Transmembranei89 – 10921HelicalUniRule annotationAdd
    BLAST
    Transmembranei116 – 13621HelicalUniRule annotationAdd
    BLAST
    Transmembranei151 – 17121HelicalUniRule annotationAdd
    BLAST
    Transmembranei192 – 21221HelicalUniRule annotationAdd
    BLAST
    Transmembranei225 – 24521HelicalUniRule annotationAdd
    BLAST
    Transmembranei253 – 27321HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    HOGENOMiHOG000218356.
    KOiK06153.
    OMAiFNDAHAK.
    OrthoDBiEOG6QP13M.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B7GJC8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHIIELIKAL ILGLVEGATE FAPVSSTGHM IIVDDMWLKS SEFLGKYGAN    50
    TFKVVIQLGS VLAAVVVFKD KFFELLYLRK GEVRKGPRLT LMHIFVGLLP 100
    AGVLGVLFED YIDEHLFSTK TVLIGLVLGA LLMIAADRFG KRTVAQTVDD 150
    ITYKQAFIVG LVQCLSLWPG FSRSGSTISG GVLVGMSHRA AADFTFIMAV 200
    PIMAGASAIS LLKNWQYITF DALPFFVVGF ISAFVFALLA IRFFLRLINR 250
    VRLVPFAIYR IVLAAVIYVV YFA 273
    Length:273
    Mass (Da):30,068
    Last modified:February 10, 2009 - v1
    Checksum:i7E473873FEA8CEA1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000922 Genomic DNA. Translation: ACJ33576.1.
    RefSeqiWP_012574827.1. NC_011567.1.
    YP_002315561.1. NC_011567.1.

    Genome annotation databases

    EnsemblBacteriaiACJ33576; ACJ33576; Aflv_1202.
    GeneIDi7037458.
    KEGGiafl:Aflv_1202.
    PATRICi20954237. VBIAnoFla45531_1228.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000922 Genomic DNA. Translation: ACJ33576.1 .
    RefSeqi WP_012574827.1. NC_011567.1.
    YP_002315561.1. NC_011567.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 491915.Aflv_1202.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACJ33576 ; ACJ33576 ; Aflv_1202 .
    GeneIDi 7037458.
    KEGGi afl:Aflv_1202.
    PATRICi 20954237. VBIAnoFla45531_1228.

    Phylogenomic databases

    eggNOGi COG1968.
    HOGENOMi HOG000218356.
    KOi K06153.
    OMAi FNDAHAK.
    OrthoDBi EOG6QP13M.

    Enzyme and pathway databases

    BioCyci AFLA491915:GHEO-1276-MONOMER.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Encapsulated in silica: genome, proteome and physiology of the thermophilic bacterium Anoxybacillus flavithermus WK1."
      Saw J.H., Mountain B.W., Feng L., Omelchenko M.V., Hou S., Saito J.A., Stott M.B., Li D., Zhao G., Wu J., Galperin M.Y., Koonin E.V., Makarova K.S., Wolf Y.I., Rigden D.J., Dunfield P.F., Wang L., Alam M.
      Genome Biol. 9:R161.1-R161.16(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 21510 / WK1.

    Entry informationi

    Entry nameiUPPP_ANOFW
    AccessioniPrimary (citable) accession number: B7GJC8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: February 10, 2009
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3