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Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Anoxybacillus flavithermus (strain DSM 21510 / WK1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processAntibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciAFLA491915:G1GAW-1291-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance proteinUniRule annotation
Undecaprenyl pyrophosphate phosphataseUniRule annotation
Gene namesi
Name:uppPUniRule annotation
Ordered Locus Names:Aflv_1202
OrganismiAnoxybacillus flavithermus (strain DSM 21510 / WK1)
Taxonomic identifieri491915 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeAnoxybacillus
Proteomesi
  • UP000000742 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei3 – 23HelicalUniRule annotationAdd BLAST21
Transmembranei48 – 68HelicalUniRule annotationAdd BLAST21
Transmembranei89 – 109HelicalUniRule annotationAdd BLAST21
Transmembranei116 – 136HelicalUniRule annotationAdd BLAST21
Transmembranei151 – 171HelicalUniRule annotationAdd BLAST21
Transmembranei192 – 212HelicalUniRule annotationAdd BLAST21
Transmembranei225 – 245HelicalUniRule annotationAdd BLAST21
Transmembranei253 – 273HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001973471 – 273Undecaprenyl-diphosphataseAdd BLAST273

Proteomic databases

PRIDEiB7GJC8

Interactioni

Protein-protein interaction databases

STRINGi491915.Aflv_1202

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DWR Bacteria
COG1968 LUCA
HOGENOMiHOG000218356
KOiK06153
OMAiVFKDRIL
OrthoDBiPOG091H00ZR

Family and domain databases

HAMAPiMF_01006 Undec_diphosphatase, 1 hit
InterProiView protein in InterPro
IPR003824 UppP
PANTHERiPTHR30622 PTHR30622, 1 hit
PfamiView protein in Pfam
PF02673 BacA, 1 hit
TIGRFAMsiTIGR00753 undec_PP_bacA, 1 hit

Sequencei

Sequence statusi: Complete.

B7GJC8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHIIELIKAL ILGLVEGATE FAPVSSTGHM IIVDDMWLKS SEFLGKYGAN
60 70 80 90 100
TFKVVIQLGS VLAAVVVFKD KFFELLYLRK GEVRKGPRLT LMHIFVGLLP
110 120 130 140 150
AGVLGVLFED YIDEHLFSTK TVLIGLVLGA LLMIAADRFG KRTVAQTVDD
160 170 180 190 200
ITYKQAFIVG LVQCLSLWPG FSRSGSTISG GVLVGMSHRA AADFTFIMAV
210 220 230 240 250
PIMAGASAIS LLKNWQYITF DALPFFVVGF ISAFVFALLA IRFFLRLINR
260 270
VRLVPFAIYR IVLAAVIYVV YFA
Length:273
Mass (Da):30,068
Last modified:February 10, 2009 - v1
Checksum:i7E473873FEA8CEA1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000922 Genomic DNA Translation: ACJ33576.1
RefSeqiWP_012574827.1, NC_011567.1

Genome annotation databases

EnsemblBacteriaiACJ33576; ACJ33576; Aflv_1202
KEGGiafl:Aflv_1202
PATRICifig|491915.6.peg.1228

Similar proteinsi

Entry informationi

Entry nameiUPPP_ANOFW
AccessioniPrimary (citable) accession number: B7GJC8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 10, 2009
Last modified: May 23, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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