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Protein

Catalase-peroxidase

Gene

katG

Organism
Anoxybacillus flavithermus (strain DSM 21510 / WK1)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotationSAAS annotation

Catalytic activityi

2 H2O2 = O2 + 2 H2O.UniRule annotationSAAS annotation
Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotationSAAS annotation

Cofactori

heme bUniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei123 – 1231Transition state stabilizerUniRule annotation
Active sitei127 – 1271Proton acceptorUniRule annotation
Metal bindingi290 – 2901Iron (heme axial ligand)UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxideUniRule annotationSAAS annotation

Keywords - Ligandi

HemeUniRule annotationSAAS annotation, Iron, Metal-binding

Enzyme and pathway databases

BioCyciAFLA491915:GHEO-1274-MONOMER.

Protein family/group databases

PeroxiBasei7325. AflaCP01.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:Aflv_1200Imported
OrganismiAnoxybacillus flavithermus (strain DSM 21510 / WK1)Imported
Taxonomic identifieri491915 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeAnoxybacillus
Proteomesi
  • UP000000742 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki126 ↔ 249Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-275)UniRule annotation
Cross-linki249 ↔ 275Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-126)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi491915.Aflv_1200.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini160 – 436277PEROXIDASE_4InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiTESKCPF.
OrthoDBiEOG6RRKKM.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7GJC6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLIIITSLCI QLRDNSFYSY ARKGNKRMEN KNEHVSKCPF HGSVTSHASN
60 70 80 90 100
KTTNKDWWPN QLNLNILHQH DRKTNPHDET FDYTEEFQKL DYWALKEDLR
110 120 130 140 150
KLMTTSQDWW PADYGHYGPL FIRMAWHSAG TYRIGDGRGG ASTGTQRFAP
160 170 180 190 200
LNSWPDNANL DKARRLLWPI KQKYGNKISW ADLIVLAGNV AIESMGGKTI
210 220 230 240 250
GFGAGREDVW HPEEDIYWGA EKEWLASERY TGDRELENPL AAVQMGLIYV
260 270 280 290 300
NPEGPDGNPD PLAAARDIRE TFKRMGMNDE ETVALIAGGH TFGKAHGAGD
310 320 330 340 350
ASHVGPEPEA APIEAQGLGW ISSYGKGKGR DTITSGLEGA WTPTPTKWDN
360 370 380 390 400
SYLQLLFEYE WKLTKSPAGA YQWEAVNLKE EHLAPDVEDA NKKVPPMMLT
410 420 430 440 450
TDLALRFDPA YEKIARRFYE HPEEFADAFA RAWFKLIHRD MGPKTRYLGP
460 470 480 490 500
EVPKEDFIWQ DPIPAVDVEL TDAEIEDIKT RILQSGLTVS ELVKTAWASA
510 520 530 540 550
STFRNSDKRG GANGARIRLA PQKDWEVNEP ERLAKVLSVY EDIQRELPKK
560 570 580 590 600
VSLADLIVLG GSAAVEKAAR DAGFDVRVPF MPGRGDATEE QTDVESFAVL
610 620 630 640 650
EPVADGFRNY QKKKYSVTPE ELLVDKAQLL GLTAPEMTVL VGGLRVLGAT
660 670 680 690 700
YRNLPHGVFT DRIGVLTNDF FVHLVDMNYE WVPKEDGLYD IRDRKTGEVR
710 720 730 740 750
WTATRVDLVF GSNSILRSYA EFYAQDDNKE KFVHDFIKAW VKVMNADRFD
760
LRKKTKASVT V
Length:761
Mass (Da):86,027
Last modified:February 10, 2009 - v1
Checksum:i272EE27CCBEEC29C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000922 Genomic DNA. Translation: ACJ33574.1.

Genome annotation databases

EnsemblBacteriaiACJ33574; ACJ33574; Aflv_1200.
KEGGiafl:Aflv_1200.
PATRICi20954233. VBIAnoFla45531_1226.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000922 Genomic DNA. Translation: ACJ33574.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi491915.Aflv_1200.

Protein family/group databases

PeroxiBasei7325. AflaCP01.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACJ33574; ACJ33574; Aflv_1200.
KEGGiafl:Aflv_1200.
PATRICi20954233. VBIAnoFla45531_1226.

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiTESKCPF.
OrthoDBiEOG6RRKKM.

Enzyme and pathway databases

BioCyciAFLA491915:GHEO-1274-MONOMER.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Encapsulated in silica: genome, proteome and physiology of the thermophilic bacterium Anoxybacillus flavithermus WK1."
    Saw J.H., Mountain B.W., Feng L., Omelchenko M.V., Hou S., Saito J.A., Stott M.B., Li D., Zhao G., Wu J., Galperin M.Y., Koonin E.V., Makarova K.S., Wolf Y.I., Rigden D.J., Dunfield P.F., Wang L., Alam M.
    Genome Biol. 9:R161.1-R161.16(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 21510 / WK1Imported.

Entry informationi

Entry nameiB7GJC6_ANOFW
AccessioniPrimary (citable) accession number: B7GJC6
Entry historyi
Integrated into UniProtKB/TrEMBL: February 10, 2009
Last sequence update: February 10, 2009
Last modified: July 6, 2016
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.