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B7GIK0

- GSA1_ANOFW

UniProt

B7GIK0 - GSA1_ANOFW

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Protein
Glutamate-1-semialdehyde 2,1-aminomutase 1
Gene
hemL1, Aflv_0363
Organism
Anoxybacillus flavithermus (strain DSM 21510 / WK1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro
  3. transaminase activity Source: InterPro

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Porphyrin biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciAFLA491915:GHEO-413-MONOMER.
UniPathwayiUPA00251; UER00317.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutase 1 (EC:5.4.3.8)
Short name:
GSA 1
Alternative name(s):
Glutamate-1-semialdehyde aminotransferase 1
Short name:
GSA-AT 1
Gene namesi
Name:hemL1
Ordered Locus Names:Aflv_0363
OrganismiAnoxybacillus flavithermus (strain DSM 21510 / WK1)
Taxonomic identifieri491915 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeAnoxybacillus
ProteomesiUP000000742: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 431431Glutamate-1-semialdehyde 2,1-aminomutase 1UniRule annotation
PRO_0000382250Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei268 – 2681N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi491915.Aflv_0363.

Structurei

3D structure databases

ProteinModelPortaliB7GIK0.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0001.
HOGENOMiHOG000020210.
KOiK01845.
OMAiPVVMERA.
OrthoDBiEOG6QVRHN.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_00375. HemL_aminotrans_3.
InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00713. hemL. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7GIK0-1 [UniParc]FASTAAdd to Basket

« Hide

MNFTKSEQLY QEALEHIVGG VNSPSRSYKA VGGGAPVVME RAQGAYFWDV    50
DGNKYIDYLA AYGPIITGHA HPHITKAIQH AAENGVLYGT PTPYEITFAK 100
MLKEAIPSLE KVRFVNSGTE AVMTTIRVAR AYTGRDKIVK FAGCYHGHSD 150
LVLVAAGSGP STLGTPDSAG VPKSIAQEVI TVPFNDVDAF KQAMDRWGNE 200
VAAVLVEPIV GNFGIVEPKP GFLQAINDIA HAVGALVIYD EVITAFRFMY 250
GGAQNLLGIE PDLTALGKII GGGLPIGAYG GRKDIMEQVA PLGPAYQAGT 300
MAGNPASILA GIACLEVLQQ EGVYEHLDHL GAMLEAGILT HAKTYDIPIT 350
INRLKGALTV YFTTEKVENY EQAERTDGEM FAKFFKLMLH QGINLAPSKY 400
EAWFITLAHT EEDIEYTIEA VERAFKSLKN E 431
Length:431
Mass (Da):46,612
Last modified:September 1, 2009 - v2
Checksum:i90240E1106766267
GO

Sequence cautioni

The sequence ACJ32747.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000922 Genomic DNA. Translation: ACJ32747.1. Different initiation.
RefSeqiYP_002314732.1. NC_011567.1.

Genome annotation databases

EnsemblBacteriaiACJ32747; ACJ32747; Aflv_0363.
GeneIDi7036595.
KEGGiafl:Aflv_0363.
PATRICi20952471. VBIAnoFla45531_0372.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000922 Genomic DNA. Translation: ACJ32747.1 . Different initiation.
RefSeqi YP_002314732.1. NC_011567.1.

3D structure databases

ProteinModelPortali B7GIK0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 491915.Aflv_0363.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACJ32747 ; ACJ32747 ; Aflv_0363 .
GeneIDi 7036595.
KEGGi afl:Aflv_0363.
PATRICi 20952471. VBIAnoFla45531_0372.

Phylogenomic databases

eggNOGi COG0001.
HOGENOMi HOG000020210.
KOi K01845.
OMAi PVVMERA.
OrthoDBi EOG6QVRHN.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00317 .
BioCyci AFLA491915:GHEO-413-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPi MF_00375. HemL_aminotrans_3.
InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR00713. hemL. 1 hit.
PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Encapsulated in silica: genome, proteome and physiology of the thermophilic bacterium Anoxybacillus flavithermus WK1."
    Saw J.H., Mountain B.W., Feng L., Omelchenko M.V., Hou S., Saito J.A., Stott M.B., Li D., Zhao G., Wu J., Galperin M.Y., Koonin E.V., Makarova K.S., Wolf Y.I., Rigden D.J., Dunfield P.F., Wang L., Alam M.
    Genome Biol. 9:R161.1-R161.16(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 21510 / WK1.

Entry informationi

Entry nameiGSA1_ANOFW
AccessioniPrimary (citable) accession number: B7GIK0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: September 1, 2009
Last modified: May 14, 2014
This is version 42 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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