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B7GIC0 (DAPEL_ANOFW) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
N-acetyldiaminopimelate deacetylase
EC=3.5.1.47
Gene names
Ordered Locus Names:Aflv_1903
OrganismAnoxybacillus flavithermus (strain DSM 21510 / WK1) [Complete proteome] [HAMAP]
Taxonomic identifier491915 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Anoxybacillus ›

Protein attributes

Sequence length378 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate By similarity. HAMAP-Rule MF_01692

Catalytic activity

N-acetyl-LL-2,6-diaminoheptanedioate + H2O = acetate + LL-2,6-diaminoheptanedioate. HAMAP-Rule MF_01692

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (acetylase route): step 3/3. HAMAP-Rule MF_01692

Sequence similarities

Belongs to the peptidase M20A family. N-acetyldiaminopimelate deacetylase subfamily.

Sequence caution

The sequence ACJ34264.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 378378N-acetyldiaminopimelate deacetylase HAMAP-Rule MF_01692
PRO_0000376734

Sites

Active site651 By similarity
Active site1241Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
B7GIC0 [UniParc].

Last modified May 26, 2009. Version 2.
Checksum: 6C7DC3BED17E1AD9

FASTA37842,584
        10         20         30         40         50         60 
MFVNIRRDLH QIPELGFQEF KTQQYILDYL ATLPSERLQI KTWRTGILVR VHGTAPTKTI 

        70         80         90        100        110        120 
GYRADMDGLP IDEQTDVPFR STHEGRMHAC GHDMHMAIAL GVLTHVVHHP IRDDMLFIFQ 

       130        140        150        160        170        180 
PAEEGPGGAL PMLESDEMKQ WMPDMILALH IAPAYPVGTI ATKEGLLFAN TSELFIDLIG 

       190        200        210        220        230        240 
KGGHAAFPHE TKDMVVAASS LIMQLQTIVS RNVNPLDSAV ITIGKLTSGT VQNVIAERAR 

       250        260        270        280        290        300 
LEGTIRTLSP EAMEKVKGRI EAIVRGIEVA YDCQAHIDYG SMYYQVYNDE TLTNEFMQFV 

       310        320        330        340        350        360 
EKETDVHLVR CQEAMTGEDF GYMLARIPGF MFWLGVQSPF GLHHAKLNPN EEAIDVAIQL 

       370 
LTRYVTWKGN HKVKEEER

« Hide

References

[1]"Encapsulated in silica: genome, proteome and physiology of the thermophilic bacterium Anoxybacillus flavithermus WK1."
Saw J.H., Mountain B.W., Feng L., Omelchenko M.V., Hou S., Saito J.A., Stott M.B., Li D., Zhao G., Wu J., Galperin M.Y., Koonin E.V., Makarova K.S., Wolf Y.I., Rigden D.J., Dunfield P.F., Wang L., Alam M.
Genome Biol. 9:R161.1-R161.16(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 21510 / WK1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000922 Genomic DNA. Translation: ACJ34264.1. Different initiation.
RefSeqYP_002316249.1. NC_011567.1.

3D structure databases

ProteinModelPortalB7GIC0.
ModBaseSearch...

Protein-protein interaction databases

STRING491915.Aflv_1903.

Protein family/group databases

MEROPSM20.A27.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACJ34264; ACJ34264; Aflv_1903.
GeneID7038156.
KEGGafl:Aflv_1903.
PATRIC20955697. VBIAnoFla45531_1957.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1473.
HOGENOMHOG000241404.
KOK05823.
ProtClustDBCLSK873387.

Enzyme and pathway databases

BioCycAFLA491915:GHEO-1973-MONOMER.
UniPathwayUPA00034; UER00024.

Family and domain databases

Gene3D3.30.70.360. 1 hit.
HAMAPMF_01692. DapEL.
InterProIPR023905. AcetylDAP_deacetylase.
IPR017439. Amidohydrolase.
IPR002933. Peptidase_M20.
IPR011650. Peptidase_M20_dimer.
[Graphical view]
PfamPF07687. M20_dimer. 1 hit.
PF01546. Peptidase_M20. 1 hit.
[Graphical view]
PIRSFPIRSF005962. Pept_M20D_amidohydro. 1 hit.
SUPFAMSSF55031. Peptidase_M20_dimer. 1 hit.
TIGRFAMsTIGR01891. amidohydrolases. 1 hit.
PROSITEPS00758. ARGE_DAPE_CPG2_1. False negative.
PS00759. ARGE_DAPE_CPG2_2. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDAPEL_ANOFW
AccessionPrimary (citable) accession number: B7GIC0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: May 26, 2009
Last modified: May 29, 2013
This is version 33 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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