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Protein

Dihydrolipoyl dehydrogenase

Gene

pdhD

Organism
Anoxybacillus flavithermus (strain DSM 21510 / WK1)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Catalytic activityi

Protein N(6)-(dihydrolipoyl)lysine + NAD+ = protein N(6)-(lipoyl)lysine + NADH.UniRule annotation

Cofactori

FADUniRule annotationNote: Binds 1 FAD per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

GlycolysisSAAS annotation

Keywords - Ligandi

FADUniRule annotation, Flavoprotein, NADUniRule annotation, PyruvateImported

Enzyme and pathway databases

BioCyciAFLA491915:GHEO-1962-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydrolipoyl dehydrogenaseUniRule annotation (EC:1.8.1.4UniRule annotation)
Gene namesi
Name:pdhDImported
Ordered Locus Names:Aflv_1891Imported
OrganismiAnoxybacillus flavithermus (strain DSM 21510 / WK1)Imported
Taxonomic identifieri491915 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeAnoxybacillus
Proteomesi
  • UP000000742 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi491915.Aflv_1891.

Structurei

3D structure databases

ProteinModelPortaliB7GIA8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 329318FAD/NAD-binding_domInterPro annotationAdd
BLAST
Domaini348 – 456109Pyr_redox_dimInterPro annotationAdd
BLAST

Keywords - Domaini

Redox-active centerUniRule annotation

Phylogenomic databases

eggNOGiENOG4107QN2. Bacteria.
COG1249. LUCA.
HOGENOMiHOG000276708.
KOiK00382.
OMAiYTSPEWA.
OrthoDBiEOG6QCD6D.

Family and domain databases

Gene3Di3.30.390.30. 1 hit.
3.50.50.60. 2 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR006258. Lipoamide_DH.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR012999. Pyr_OxRdtase_I_AS.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
SSF55424. SSF55424. 1 hit.
TIGRFAMsiTIGR01350. lipoamide_DH. 1 hit.
PROSITEiPS00076. PYRIDINE_REDOX_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7GIA8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVVGDFAIET ETLVVGAGPG GYVAAIRAAQ LGQKVTIVEK GNLGGVCLNV
60 70 80 90 100
GCIPSKALIS AGHRYEIATH SQDMGIFAEN VKVDFSKVQE WKAGVVKKLT
110 120 130 140 150
GGVEGLLKGN KVEIVRGEAY FVDENTVRVM TENSAQTYKF KNAIIATGSR
160 170 180 190 200
PIELPTFKFS KRVLDSTGAL NLPDIPKSMV VIGGGYIGTE LGTAYANFGT
210 220 230 240 250
KITILEGADE ILSGFEKQMS AVVRRRLKKK GVDVFTNALA KGVEEREDGV
260 270 280 290 300
TVTFEVNGET KTIDAEYVLV TVGRRPNTEE MGLEQIGINM TERGLIEIDK
310 320 330 340 350
QCRTSVPNIY AIGDVVAGPP LAHKASYEGK IAAEAIAGHP SEIDYLAIPA
360 370 380 390 400
VVFSDPECAS VGYFEKQAIE EGIDVITAKF PFGANGRALA LNETDGFLKL
410 420 430 440 450
VLTKDDGVII GAQIVGPNAS DMIAELGLAI EAGMTAEDIA MTIHAHPTLG
460 470
EITMEAAEVA LGSPIHIINK
Length:470
Mass (Da):49,883
Last modified:February 10, 2009 - v1
Checksum:i26A1DA4C19736073
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000922 Genomic DNA. Translation: ACJ34252.1.
RefSeqiWP_012575445.1. NC_011567.1.

Genome annotation databases

EnsemblBacteriaiACJ34252; ACJ34252; Aflv_1891.
GeneIDi7038144.
KEGGiafl:Aflv_1891.
PATRICi20955673. VBIAnoFla45531_1945.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000922 Genomic DNA. Translation: ACJ34252.1.
RefSeqiWP_012575445.1. NC_011567.1.

3D structure databases

ProteinModelPortaliB7GIA8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi491915.Aflv_1891.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACJ34252; ACJ34252; Aflv_1891.
GeneIDi7038144.
KEGGiafl:Aflv_1891.
PATRICi20955673. VBIAnoFla45531_1945.

Phylogenomic databases

eggNOGiENOG4107QN2. Bacteria.
COG1249. LUCA.
HOGENOMiHOG000276708.
KOiK00382.
OMAiYTSPEWA.
OrthoDBiEOG6QCD6D.

Enzyme and pathway databases

BioCyciAFLA491915:GHEO-1962-MONOMER.

Family and domain databases

Gene3Di3.30.390.30. 1 hit.
3.50.50.60. 2 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR006258. Lipoamide_DH.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR012999. Pyr_OxRdtase_I_AS.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
SSF55424. SSF55424. 1 hit.
TIGRFAMsiTIGR01350. lipoamide_DH. 1 hit.
PROSITEiPS00076. PYRIDINE_REDOX_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Encapsulated in silica: genome, proteome and physiology of the thermophilic bacterium Anoxybacillus flavithermus WK1."
    Saw J.H., Mountain B.W., Feng L., Omelchenko M.V., Hou S., Saito J.A., Stott M.B., Li D., Zhao G., Wu J., Galperin M.Y., Koonin E.V., Makarova K.S., Wolf Y.I., Rigden D.J., Dunfield P.F., Wang L., Alam M.
    Genome Biol. 9:R161.1-R161.16(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 21510 / WK1Imported.

Entry informationi

Entry nameiB7GIA8_ANOFW
AccessioniPrimary (citable) accession number: B7GIA8
Entry historyi
Integrated into UniProtKB/TrEMBL: February 10, 2009
Last sequence update: February 10, 2009
Last modified: April 13, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

The active site is a redox-active disulfide bond.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.