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Protein

Dihydrolipoyl dehydrogenase

Gene

pdhD

Organism
Anoxybacillus flavithermus (strain DSM 21510 / WK1)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Miscellaneous

The active site is a redox-active disulfide bond.UniRule annotation

Catalytic activityi

Protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH.UniRule annotation

Cofactori

FADUniRule annotationNote: Binds 1 FAD per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandFADUniRule annotation, Flavoprotein, NADUniRule annotation, PyruvateImported

Enzyme and pathway databases

BioCyciAFLA491915:G1GAW-2004-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydrolipoyl dehydrogenaseUniRule annotation (EC:1.8.1.4UniRule annotation)
Gene namesi
Name:pdhDImported
Ordered Locus Names:Aflv_1891Imported
OrganismiAnoxybacillus flavithermus (strain DSM 21510 / WK1)Imported
Taxonomic identifieri491915 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeAnoxybacillus
Proteomesi
  • UP000000742 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Interactioni

Protein-protein interaction databases

STRINGi491915.Aflv_1891

Structurei

3D structure databases

ProteinModelPortaliB7GIA8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 329FAD/NAD-binding_domInterPro annotationAdd BLAST318
Domaini348 – 456Pyr_redox_dimInterPro annotationAdd BLAST109

Sequence similaritiesi

Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.UniRule annotation

Keywords - Domaini

Redox-active centerUniRule annotation

Phylogenomic databases

eggNOGiENOG4107QN2 Bacteria
COG1249 LUCA
HOGENOMiHOG000276708
KOiK00382
OMAiTMSEAVM
OrthoDBiPOG091H0239

Family and domain databases

Gene3Di3.30.390.301 hit
3.50.50.603 hits
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR023753 FAD/NAD-binding_dom
IPR016156 FAD/NAD-linked_Rdtase_dimer_sf
IPR006258 Lipoamide_DH
IPR001100 Pyr_nuc-diS_OxRdtase
IPR004099 Pyr_nucl-diS_OxRdtase_dimer
IPR012999 Pyr_OxRdtase_I_AS
PfamiView protein in Pfam
PF07992 Pyr_redox_2, 1 hit
PF02852 Pyr_redox_dim, 1 hit
PIRSFiPIRSF000350 Mercury_reductase_MerA, 1 hit
SUPFAMiSSF51905 SSF51905, 1 hit
SSF55424 SSF55424, 1 hit
TIGRFAMsiTIGR01350 lipoamide_DH, 1 hit
PROSITEiView protein in PROSITE
PS00076 PYRIDINE_REDOX_1, 1 hit

Sequencei

Sequence statusi: Complete.

B7GIA8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVVGDFAIET ETLVVGAGPG GYVAAIRAAQ LGQKVTIVEK GNLGGVCLNV
60 70 80 90 100
GCIPSKALIS AGHRYEIATH SQDMGIFAEN VKVDFSKVQE WKAGVVKKLT
110 120 130 140 150
GGVEGLLKGN KVEIVRGEAY FVDENTVRVM TENSAQTYKF KNAIIATGSR
160 170 180 190 200
PIELPTFKFS KRVLDSTGAL NLPDIPKSMV VIGGGYIGTE LGTAYANFGT
210 220 230 240 250
KITILEGADE ILSGFEKQMS AVVRRRLKKK GVDVFTNALA KGVEEREDGV
260 270 280 290 300
TVTFEVNGET KTIDAEYVLV TVGRRPNTEE MGLEQIGINM TERGLIEIDK
310 320 330 340 350
QCRTSVPNIY AIGDVVAGPP LAHKASYEGK IAAEAIAGHP SEIDYLAIPA
360 370 380 390 400
VVFSDPECAS VGYFEKQAIE EGIDVITAKF PFGANGRALA LNETDGFLKL
410 420 430 440 450
VLTKDDGVII GAQIVGPNAS DMIAELGLAI EAGMTAEDIA MTIHAHPTLG
460 470
EITMEAAEVA LGSPIHIINK
Length:470
Mass (Da):49,883
Last modified:February 10, 2009 - v1
Checksum:i26A1DA4C19736073
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000922 Genomic DNA Translation: ACJ34252.1
RefSeqiWP_012575445.1, NC_011567.1

Genome annotation databases

EnsemblBacteriaiACJ34252; ACJ34252; Aflv_1891
KEGGiafl:Aflv_1891
PATRICifig|491915.6.peg.1945

Similar proteinsi

Entry informationi

Entry nameiB7GIA8_ANOFW
AccessioniPrimary (citable) accession number: B7GIA8
Entry historyiIntegrated into UniProtKB/TrEMBL: February 10, 2009
Last sequence update: February 10, 2009
Last modified: February 28, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported