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B7GHD4

- B7GHD4_ANOFW

UniProt

B7GHD4 - B7GHD4_ANOFW

Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene

gcvPB

Organism
Anoxybacillus flavithermus (strain DSM 21510 / WK1)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (10 Feb 2009)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationSAAS annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciAFLA491915:GHEO-993-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-protein subunit 2UniRule annotation
    Glycine decarboxylase subunit 2UniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring) subunit 2UniRule annotation
    Gene namesi
    Name:gcvPBUniRule annotationImported
    Ordered Locus Names:Aflv_0917Imported
    OrganismiAnoxybacillus flavithermus (strain DSM 21510 / WK1)Imported
    Taxonomic identifieri491915 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeAnoxybacillus
    ProteomesiUP000000742: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei272 – 2721N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotationSAAS annotation

    Protein-protein interaction databases

    STRINGi491915.Aflv_0917.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family. C-terminal subunit subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239368.
    KOiK00283.
    OMAiWTGLMMI.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00713. GcvPB.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR023012. GDC_P_su2.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B7GHD4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHKDQPLIFE LSKPGRIGYS LPKLDVPAID VAQVIPTDYI RQEAPELPEV    50
    SELDIMRHYT ALSKRNHGVD SGFYPLGSCT MKYNPKINEN VARFAGFAHI 100
    HPLQPEETVQ GALELMYDLQ EHLKEITGMD AVTLQPAAGA HGEWTGLMMI 150
    RAYHEANGDY NRTKVIVPDT AHGTNPASAT VAGFETVTVK STEEGLVDLD 200
    DLRRVVGPDT AALMLTNPNT LGLFEENILE MAEIVHAAGG KLYYDGANLN 250
    AVLSKARPGD MGFDVVHLNL HKTFTGPHGG GGPGSGPVGV KADLIPFLPK 300
    PTVEKGENGY YFDYDRPQAI GRVKPFYGNF GINVRAYTYI RSMGPDGLKA 350
    VTEYAVLNAN YMMRRLAEYY DLPYNRHCKH EFVLSGKRQK KLGVRTLDIA 400
    KRLLDFGYHP PTIYFPLIVE ECMMIEPTET ESKETLDAFI DAMIQIAKEA 450
    EETPEIVQEA PHTTVVKRLD ETTAARKPIL RYQK 484
    Length:484
    Mass (Da):53,803
    Last modified:February 10, 2009 - v1
    Checksum:iA14A17188D34A2A3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000922 Genomic DNA. Translation: ACJ33295.1.
    RefSeqiYP_002315280.1. NC_011567.1.

    Genome annotation databases

    EnsemblBacteriaiACJ33295; ACJ33295; Aflv_0917.
    GeneIDi7037175.
    KEGGiafl:Aflv_0917.
    PATRICi20953655. VBIAnoFla45531_0937.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000922 Genomic DNA. Translation: ACJ33295.1 .
    RefSeqi YP_002315280.1. NC_011567.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 491915.Aflv_0917.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACJ33295 ; ACJ33295 ; Aflv_0917 .
    GeneIDi 7037175.
    KEGGi afl:Aflv_0917.
    PATRICi 20953655. VBIAnoFla45531_0937.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239368.
    KOi K00283.
    OMAi WTGLMMI.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci AFLA491915:GHEO-993-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00713. GcvPB.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR023012. GDC_P_su2.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Encapsulated in silica: genome, proteome and physiology of the thermophilic bacterium Anoxybacillus flavithermus WK1."
      Saw J.H., Mountain B.W., Feng L., Omelchenko M.V., Hou S., Saito J.A., Stott M.B., Li D., Zhao G., Wu J., Galperin M.Y., Koonin E.V., Makarova K.S., Wolf Y.I., Rigden D.J., Dunfield P.F., Wang L., Alam M.
      Genome Biol. 9:R161.1-R161.16(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 21510 / WK1Imported.

    Entry informationi

    Entry nameiB7GHD4_ANOFW
    AccessioniPrimary (citable) accession number: B7GHD4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 10, 2009
    Last sequence update: February 10, 2009
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3