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B7GHD4

- B7GHD4_ANOFW

UniProt

B7GHD4 - B7GHD4_ANOFW

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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene

gcvPB

Organism
Anoxybacillus flavithermus (strain DSM 21510 / WK1)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotationSAAS annotation

Cofactori

Pyridoxal phosphate.UniRule annotationSAAS annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciAFLA491915:GHEO-993-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 2UniRule annotation
Glycine decarboxylase subunit 2UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 2UniRule annotation
Gene namesi
Name:gcvPBUniRule annotationImported
Ordered Locus Names:Aflv_0917Imported
OrganismiAnoxybacillus flavithermus (strain DSM 21510 / WK1)Imported
Taxonomic identifieri491915 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeAnoxybacillus
ProteomesiUP000000742: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei272 – 2721N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi491915.Aflv_0917.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. C-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239368.
KOiK00283.
OMAiWTGLMMI.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00713. GcvPB.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

B7GHD4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHKDQPLIFE LSKPGRIGYS LPKLDVPAID VAQVIPTDYI RQEAPELPEV
60 70 80 90 100
SELDIMRHYT ALSKRNHGVD SGFYPLGSCT MKYNPKINEN VARFAGFAHI
110 120 130 140 150
HPLQPEETVQ GALELMYDLQ EHLKEITGMD AVTLQPAAGA HGEWTGLMMI
160 170 180 190 200
RAYHEANGDY NRTKVIVPDT AHGTNPASAT VAGFETVTVK STEEGLVDLD
210 220 230 240 250
DLRRVVGPDT AALMLTNPNT LGLFEENILE MAEIVHAAGG KLYYDGANLN
260 270 280 290 300
AVLSKARPGD MGFDVVHLNL HKTFTGPHGG GGPGSGPVGV KADLIPFLPK
310 320 330 340 350
PTVEKGENGY YFDYDRPQAI GRVKPFYGNF GINVRAYTYI RSMGPDGLKA
360 370 380 390 400
VTEYAVLNAN YMMRRLAEYY DLPYNRHCKH EFVLSGKRQK KLGVRTLDIA
410 420 430 440 450
KRLLDFGYHP PTIYFPLIVE ECMMIEPTET ESKETLDAFI DAMIQIAKEA
460 470 480
EETPEIVQEA PHTTVVKRLD ETTAARKPIL RYQK
Length:484
Mass (Da):53,803
Last modified:February 10, 2009 - v1
Checksum:iA14A17188D34A2A3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000922 Genomic DNA. Translation: ACJ33295.1.
RefSeqiWP_012574578.1. NC_011567.1.
YP_002315280.1. NC_011567.1.

Genome annotation databases

EnsemblBacteriaiACJ33295; ACJ33295; Aflv_0917.
GeneIDi7037175.
KEGGiafl:Aflv_0917.
PATRICi20953655. VBIAnoFla45531_0937.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000922 Genomic DNA. Translation: ACJ33295.1 .
RefSeqi WP_012574578.1. NC_011567.1.
YP_002315280.1. NC_011567.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 491915.Aflv_0917.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACJ33295 ; ACJ33295 ; Aflv_0917 .
GeneIDi 7037175.
KEGGi afl:Aflv_0917.
PATRICi 20953655. VBIAnoFla45531_0937.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239368.
KOi K00283.
OMAi WTGLMMI.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci AFLA491915:GHEO-993-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00713. GcvPB.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Encapsulated in silica: genome, proteome and physiology of the thermophilic bacterium Anoxybacillus flavithermus WK1."
    Saw J.H., Mountain B.W., Feng L., Omelchenko M.V., Hou S., Saito J.A., Stott M.B., Li D., Zhao G., Wu J., Galperin M.Y., Koonin E.V., Makarova K.S., Wolf Y.I., Rigden D.J., Dunfield P.F., Wang L., Alam M.
    Genome Biol. 9:R161.1-R161.16(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 21510 / WK1Imported.

Entry informationi

Entry nameiB7GHD4_ANOFW
AccessioniPrimary (citable) accession number: B7GHD4
Entry historyi
Integrated into UniProtKB/TrEMBL: February 10, 2009
Last sequence update: February 10, 2009
Last modified: October 29, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3