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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Anoxybacillus flavithermus (strain DSM 21510 / WK1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Enzyme and pathway databases

BioCyciAFLA491915:G1GAW-1005-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:Aflv_0916
OrganismiAnoxybacillus flavithermus (strain DSM 21510 / WK1)
Taxonomic identifieri491915 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeAnoxybacillus
Proteomesi
  • UP000000742 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001324661 – 448Probable glycine dehydrogenase (decarboxylating) subunit 1Add BLAST448

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi491915.Aflv_0916

Structurei

3D structure databases

ProteinModelPortaliB7GHD3
SMRiB7GHD3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QK8 Bacteria
COG0403 LUCA
HOGENOMiHOG000132025
KOiK00282
OMAiMYDGASA
OrthoDBiPOG091H0JKN

Family and domain databases

CDDicd00613 GDC-P, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00712 GcvPA, 1 hit
InterProiView protein in InterPro
IPR023010 GcvPA
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR42806 PTHR42806, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 1 hit
PIRSFiPIRSF006815 GcvPA, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

B7GHD3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLHRYLPMTE EDKQQMLQTI GVQSIDELFS DIPESVRFQG EYNIKPAKSE
60 70 80 90 100
PELMKELMAL AAKNADMKTH TSFLGAGVYD HYIPTIVDHV ISRSEFYTAY
110 120 130 140 150
TPYQPEISQG ELQAIFEFQT MICELTGMDV ANSSMYDGGT ALAEAALLSA
160 170 180 190 200
AHTKKKKVLL SNAVHPEYRD VVKTYAKGPG LEVVEIPYKN GVTDLAALQA
210 220 230 240 250
EMNEDVACVI VQYPNFFGQI EPLKDIEPIA HAHKGMFVVA SNPLALGVLT
260 270 280 290 300
PPGQFGADIV VGDAQPFGIP AQFGGPHCGY FAVKSALMRK IPGRLVGQTT
310 320 330 340 350
DEEGRRGFVL TLQAREQHIR RDKATSNICS NQALNALAAS VAMTALGKNG
360 370 380 390 400
VKEMATMNIQ KAHYAKEAFV SRGFHVVFEG PFFNEFVIRM NKPIAEVNKK
410 420 430 440
LLEKGIIGGY DLGRNYPELQ NCMLIAVTEL RTKEEIDTLV KELGDYNA
Length:448
Mass (Da):49,402
Last modified:February 10, 2009 - v1
Checksum:iDB3B1E55ED1369C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000922 Genomic DNA Translation: ACJ33294.1
RefSeqiWP_012574577.1, NC_011567.1

Genome annotation databases

EnsemblBacteriaiACJ33294; ACJ33294; Aflv_0916
KEGGiafl:Aflv_0916
PATRICifig|491915.6.peg.936

Entry informationi

Entry nameiGCSPA_ANOFW
AccessioniPrimary (citable) accession number: B7GHD3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 10, 2009
Last modified: April 25, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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