B7GH71 (GCST_ANOFW) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aminomethyltransferase
EC=2.1.2.10

Alternative name(s):
Glycine cleavage system T protein

Gene names

Name:	gcvT
Ordered Locus Names:	Aflv_0915

Organism

Anoxybacillus flavithermus (strain DSM 21510 / WK1) [Complete proteome] [HAMAP]

Taxonomic identifier

491915 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Anoxybacillus

Protein attributes

Sequence length	364 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine By similarity. HAMAP MF_00259
Catalytic activity	[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3. HAMAP MF_00259
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.
Sequence similarities	Belongs to the GcvT family.

Ontologies

Keywords
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	aminomethyltransferase activity Inferred from electronic annotation. Source: EC transaminase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 364	364	Aminomethyltransferase HAMAP MF_00259		PRO_1000119192

Sequences

	Sequence		Length	Mass (Da)
	B7GH71 [UniParc]. Last modified February 10, 2009. Version 1. Checksum: 2FDE99F24E316873	FASTA	364	40,279
	10 20 30 40 50 60 MLQRTPLFPL YAEYGAKTID FGGWELPVQF SSIKEEHEAV RTRAGLFDVS HMGEFEVKGK 70 80 90 100 110 120 DSVAFLQKMM TNDVAKLTDG RAQYTLMCYE DGGTVDDLLV YKKADDHYLL VVNAANIEKD 130 140 150 160 170 180 FAWLSEHVVG DVELVNISND IAQLALQGPL AEKVLQQLTT VDLSTMKFFA FADHVDVAGV 190 200 210 220 230 240 QTLVSRTGYT GEDGFELYCR AEDAPTLWRA ILEAGKEEGV LPCGLGARDT LRFEACLPLY 250 260 270 280 290 300 GQELAKDITP IEAGLGFAVK TNKDVDFFGK EILKKQKEEG APRRLVGIEM IDKGIARHGY 310 320 330 340 350 360 AVYVNNEQIG FVTTGTQSPT LKKNIGLALI STAFSSLDTE VEVDVRGKRL KARVVATPFY KRTK

References

[1]

"Encapsulated in silica: genome, proteome and physiology of the thermophilic bacterium Anoxybacillus flavithermus WK1." Saw J.H., Mountain B.W., Feng L., Omelchenko M.V., Hou S., Saito J.A., Stott M.B., Li D., Zhao G., Wu J., Galperin M.Y., Koonin E.V., Makarova K.S., Wolf Y.I., Rigden D.J., Dunfield P.F., Wang L., Alam M. Genome Biol. 9:R161.1-R161.16(2008) [PubMed: 19014707] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 21510 / WK1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000922 Genomic DNA. Translation: ACJ33293.1.
RefSeq	YP_002315278.1. NC_011567.1.
3D structure databases
ProteinModelPortal	B7GH71.
ModBase	Search...
Protein-protein interaction databases
STRING	B7GH71.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7037173.
GenomeReviews	Gene locus Aflv_0915 in contig CP000922_GR.
KEGG	afl:Aflv_0915.
PATRIC	20953651. VBIAnoFla45531_0935.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG299834.
ProtClustDB	PRK00389.
Family and domain databases
HAMAP	MF_00259. GcvT. [Tree]
InterPro	IPR013977. GCV_T_C. IPR006222. GCV_T_N. IPR006223. GcvT. IPR022903. NH2_Me_Trfase. [Graphical view]
KO	K00605.
PANTHER	PTHR13847:SF5. PTHR13847:SF5. 1 hit.
Pfam	PF01571. GCV_T. 1 hit. PF08669. GCV_T_C. 1 hit. [Graphical view]
PIRSF	PIRSF006487. GcvT. 1 hit.
TIGRFAMs	TIGR00528. GcvT. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GCST_ANOFW

Accession

Primary (citable) accession number: B7GH71

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	February 10, 2009
Last modified:	January 25, 2012
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program