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B7GH16 (B7GH16_ANOFW) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Acetolactate synthase RuleBase RU003591
EC=2.2.1.6 RuleBase RU003591
Gene names
Name:ilvB EMBL ACJ32972.1
Ordered Locus Names:Aflv_0591
OrganismAnoxybacillus flavithermus (strain DSM 21510 / WK1) [Complete proteome] [HAMAP] EMBL ACJ32972.1
Taxonomic identifier491915 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Anoxybacillus ›

Protein attributes

Sequence length602 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2 pyruvate = 2-acetolactate + CO2.

Cofactor

Binds 1 magnesium ion per subunit By similarity.

Binds 1 thiamine pyrophosphate per subunit By similarity.

Pathway

Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.

Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.

Sequence similarities

Belongs to the TPP enzyme family. RuleBase RU003702

Sequences

Sequence LengthMass (Da)Tools
B7GH16 [UniParc].

Last modified February 10, 2009. Version 1.
Checksum: 7EBFB629C050B27E

FASTA60266,250
        10         20         30         40         50         60 
MQAFSPLWSA RTDGGVRRLF LFHISFRGEK MAANMKVKER VAKKQTLCGA LMLIEALKAE 

        70         80         90        100        110        120 
NVKVIFGYPG GAVLPIYDKL YESGVFHVLT RHEQGAIHAA EGYARISGKP GVVIATSGPG 

       130        140        150        160        170        180 
ATNIVTGLTD AMMDSIPLVV FTGQVASSVI GSDAFQEADV LGITMPITKH SYQVRDVHEL 

       190        200        210        220        230        240 
PKIIKEAFHI ATTGRPGPVL IDIPKDMAVA EAEFDYEQDV QLPGYQPTTK PNHLQIRKLV 

       250        260        270        280        290        300 
EAVSQAKRPV ILAGAGVLHA NAHEQLKQYA EQQHIPVIHT LLGLGGFPAD HPLFLGMAGM 

       310        320        330        340        350        360 
HGTYTANMAL YECDLLINVG ARFDDRVTGN LAHFAPKATV AHIDIDPAEI GKNVPTKIPI 

       370        380        390        400        410        420 
VGDAKEALIQ LIEQNGKRPD VSEWLKQLNE WKREYPLMYK REPGVLKPQR LIEMIHEYTN 

       430        440        450        460        470        480 
GEAVVTTDVG QHQMWVAQYY KFKQPHRWVT SGGLGTMGFG LPAAIGAQLA QPEATVVSIV 

       490        500        510        520        530        540 
GDGGFQMTLQ ELSVIQELNL PIKIVIVNNQ ALGMVRQWQE IFYEKRYSHS LIPNQPDFVR 

       550        560        570        580        590        600 
LAEAYGMKAM RATTEEEAEY VLKEALATNA PVLLDFHVCP GENVYPMVAP GKGLHEMVGV 


KW

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References

[1]"Encapsulated in silica: genome, proteome and physiology of the thermophilic bacterium Anoxybacillus flavithermus WK1."
Saw J.H., Mountain B.W., Feng L., Omelchenko M.V., Hou S., Saito J.A., Stott M.B., Li D., Zhao G., Wu J., Galperin M.Y., Koonin E.V., Makarova K.S., Wolf Y.I., Rigden D.J., Dunfield P.F., Wang L., Alam M.
Genome Biol. 9:R161.1-R161.16(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 21510 / WK1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000922 Genomic DNA. Translation: ACJ32972.1.
RefSeqYP_002314957.1. NC_011567.1.

3D structure databases

ProteinModelPortalB7GH16.
ModBaseSearch...

Protein-protein interaction databases

STRING491915.Aflv_0591.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACJ32972; ACJ32972; Aflv_0591.
GeneID7036848.
KEGGafl:Aflv_0591.
PATRIC20952995. VBIAnoFla45531_0608.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0028.
HOGENOMHOG000258448.
KOK01652.
OMAGRYEANM.
ProtClustDBPRK07710.

Enzyme and pathway databases

BioCycAFLA491915:GHEO-666-MONOMER.
UniPathwayUPA00047; UER00055.
UPA00049; UER00059.

Family and domain databases

InterProIPR012846. Acetolactate_synth_lsu.
IPR012000. Thiamin_PyroP_enz_cen_dom.
IPR012001. Thiamin_PyroP_enz_TPP-bd_dom.
IPR000399. TPP-bd_CS.
IPR011766. TPP_enzyme-bd_C.
[Graphical view]
PANTHERPTHR18968:SF13. PTHR18968:SF13. 1 hit.
PfamPF02775. TPP_enzyme_C. 1 hit.
PF00205. TPP_enzyme_M. 1 hit.
PF02776. TPP_enzyme_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR00118. acolac_lg. 1 hit.
PROSITEPS00187. TPP_ENZYMES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB7GH16_ANOFW
AccessionPrimary (citable) accession number: B7GH16
Entry history
Integrated into UniProtKB/TrEMBL: February 10, 2009
Last sequence update: February 10, 2009
Last modified: May 1, 2013
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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