B7GGW0 (ARAA_ANOFW) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
L-arabinose isomerase
EC=5.3.1.4

Gene names

Name:	araA
Ordered Locus Names:	Aflv_0531

Organism

Anoxybacillus flavithermus (strain DSM 21510 / WK1) [Complete proteome] [HAMAP]

Taxonomic identifier

491915 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Anoxybacillus

Protein attributes

Sequence length	500 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of L-arabinose to L-ribulose By similarity. HAMAP MF_00519
Catalytic activity	L-arabinose = L-ribulose. HAMAP MF_00519
Cofactor	Binds 1 manganese ion per subunit By similarity. HAMAP MF_00519
Pathway	Carbohydrate degradation; L-arabinose degradation via L-ribulose; D-xylulose 5-phosphate from L-arabinose (bacterial route): step 1/3. HAMAP MF_00519
Sequence similarities	Belongs to the arabinose isomerase family.

Ontologies

Keywords
Biological process	Arabinose catabolism Carbohydrate metabolism
Ligand	Manganese Metal-binding
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arabinose catabolic process Inferred from electronic annotation. Source: UniProtKB-KW fucose metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	L-arabinose isomerase activity Inferred from electronic annotation. Source: EC L-fucose isomerase activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 500	500	L-arabinose isomerase HAMAP MF_00519		PRO_1000127596
Sites
	Metal binding	306	1	Manganese By similarity
	Metal binding	331	1	Manganese By similarity
	Metal binding	348	1	Manganese By similarity
	Metal binding	447	1	Manganese By similarity

Sequences

	Sequence		Length	Mass (Da)
	B7GGW0 [UniParc]. Last modified February 10, 2009. Version 1. Checksum: D12549B1745535A9	FASTA	500	56,206
	10 20 30 40 50 60 MLLLRPYEFW FVTGSQHLYG EEVLQQVEGH SRTIVNELNR DSVFPFSFVF KSVVTTPEEI 70 80 90 100 110 120 RNVCLEANAS EQCAGVITWM HTFSPAKMWI GGLLELRKPL LHLHTQFNRD IPWDSIDMDF 130 140 150 160 170 180 MNLNQSAHGD REYGFIGARM GVARKVVVGH WEDPEVRERL AKWMRTAVAF AESRQLKVAR 190 200 210 220 230 240 FGDNMREVAV TEGDKVGAQI QFGWSVNGYG VGDLVQSIRD VSEQSINELL DEYAELYDMV 250 260 270 280 290 300 PAGRQDGPVR ESIREQARIE LGLKAFLQDG NFTAFTTTFE DLHGMKQLPG LAVQRLMAEG 310 320 330 340 350 360 YGFGGEGDWK TAALVRLMKV MADGKGTSFM EDYTYHFEPG NELILGAHML EVCPTIAATR 370 380 390 400 410 420 PRIEVHPLSI GGKEDPARLV FDGGEGAAVN ASLIDLGHRF RLIVNEVDAV KPKHNMPKLP 430 440 450 460 470 480 VARILWKPRP SLRDSAEAWI LAGGAHHTCF SFAVTTEQLQ DFAEIIGVEC VVINEHTSVA 490 500 SFKNELRWNE VFWGRKQGLL

References

[1]

"Encapsulated in silica: genome, proteome and physiology of the thermophilic bacterium Anoxybacillus flavithermus WK1." Saw J.H., Mountain B.W., Feng L., Omelchenko M.V., Hou S., Saito J.A., Stott M.B., Li D., Zhao G., Wu J., Galperin M.Y., Koonin E.V., Makarova K.S., Wolf Y.I., Rigden D.J., Dunfield P.F., Wang L., Alam M. Genome Biol. 9:R161.1-R161.16(2008) [PubMed: 19014707] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 21510 / WK1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000922 Genomic DNA. Translation: ACJ32915.1.
RefSeq	YP_002314900.1. NC_011567.1.
3D structure databases
ProteinModelPortal	B7GGW0.
ModBase	Search...
Protein-protein interaction databases
STRING	B7GGW0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7036788.
GenomeReviews	Gene locus Aflv_0531 in contig CP000922_GR.
KEGG	afl:Aflv_0531.
PATRIC	20952865. VBIAnoFla45531_0544.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG297198.
ProtClustDB	PRK02929.
Family and domain databases
HAMAP	MF_00519. Arabinose_Isome. [Tree]
InterPro	IPR024664. Ara_Isoase_C. IPR004216. Fuc/Ara_isomerase_C. IPR009015. Fucose_isomerase_N/cen. IPR003762. Lara_isomerase. [Graphical view]
KO	K01804.
Pfam	PF11762. Arabinose_Iso_C. 1 hit. PF02610. Arabinose_Isome. 1 hit. [Graphical view]
PIRSF	PIRSF001478. L-ara_isomerase. 1 hit.
ProDom	PD018364. Lara_isomerase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF50443. Fuc_isomerase_C. 1 hit. SSF53743. Fuc_isomerase_N. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARAA_ANOFW

Accession

Primary (citable) accession number: B7GGW0

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	February 10, 2009
Last modified:	January 25, 2012
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program