B7GGR5 (ARLY_ANOFW) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Argininosuccinate lyase
Short name=ASAL
EC=4.3.2.1

Alternative name(s):
Arginosuccinase

Gene names

Name:	argH
Ordered Locus Names:	Aflv_0483

Organism

Anoxybacillus flavithermus (strain DSM 21510 / WK1) [Complete proteome] [HAMAP]

Taxonomic identifier

491915 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Anoxybacillus

Protein attributes

Sequence length	458 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006
Subcellular location	Cytoplasm By similarity HAMAP MF_00006.
Sequence similarities	Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process via ornithine Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	argininosuccinate lyase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 458	458	Argininosuccinate lyase HAMAP MF_00006		PRO_1000116195

Sequences

	Sequence		Length	Mass (Da)
	B7GGR5 [UniParc]. Last modified February 10, 2009. Version 1. Checksum: BFC76268E2BA2DAA	FASTA	458	51,859
	10 20 30 40 50 60 MKKLWGGRFT KTAAQWVDDF GASIHFDQQL VEEDIEGSIA HVTMLGECGI LPKEDVETIK 70 80 90 100 110 120 KGLTKLLEKA KRGELSFSVT YEDIHLNIEK MLIDEIGPVG GKLHTGRSRN DQVATDMHLY 130 140 150 160 170 180 LRKRVIEIIE LIRQLQRVLV EKAEQHIETL IPGYTHLQRA QPISFAHHLM AYVWMFERDR 190 200 210 220 230 240 ERFAESLKRM NKSPLGAGAL AGTTFPIDRH LTARLLGFDG IYENSLDAVS DRDFIIEFLS 250 260 270 280 290 300 NSSILMMHLS RFCEELILWS SQEFQFIEMD DTFATGSSIM PQKKNPDMAE LIRGKTGRVY 310 320 330 340 350 360 GHLMALLTVM KGLPLAYNKD MQEDKEGMFD TVQTVIGSLN IFAGMIETMT IRTDVMEKAT 370 380 390 400 410 420 KQDFSNATEL ADYLAKKGVP FREAHEIVGK LVLTCIERGV FLADLPLHVY QQASPLFEED 430 440 450 IYEALNPYTA VNRRTSAGGT GFTEVKKAIE KAKQMIEA

References

[1]

"Encapsulated in silica: genome, proteome and physiology of the thermophilic bacterium Anoxybacillus flavithermus WK1." Saw J.H., Mountain B.W., Feng L., Omelchenko M.V., Hou S., Saito J.A., Stott M.B., Li D., Zhao G., Wu J., Galperin M.Y., Koonin E.V., Makarova K.S., Wolf Y.I., Rigden D.J., Dunfield P.F., Wang L., Alam M. Genome Biol. 9:R161.1-R161.16(2008) [PubMed: 19014707] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 21510 / WK1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000922 Genomic DNA. Translation: ACJ32867.1.
RefSeq	YP_002314852.1. NC_011567.1.
3D structure databases
ProteinModelPortal	B7GGR5.
ModBase	Search...
Protein-protein interaction databases
STRING	B7GGR5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7036740.
GenomeReviews	Gene locus Aflv_0483 in contig CP000922_GR.
KEGG	afl:Aflv_0483.
PATRIC	20952767. VBIAnoFla45531_0495.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG539632.
ProtClustDB	PRK00855.
Family and domain databases
HAMAP	MF_00006. Arg_succ_lyase. [Tree]
InterPro	IPR009049. Argininosuccinate_lyase. IPR003031. D_crystallin. IPR000362. Fumarate_lyase. IPR020557. Fumarate_lyase_CS. IPR008948. L-Aspartase-like. IPR022761. Lyase1_N. [Graphical view]
KO	K01755.
PANTHER	PTHR11444:SF3. argH. 1 hit.
Pfam	PF00206. Lyase_1. 1 hit. [Graphical view]
PRINTS	PR00145. ARGSUCLYASE. PR00149. FUMRATELYASE.
SUPFAM	SSF48557. L-Aspartase-like. 1 hit.
TIGRFAMs	TIGR00838. ArgH. 1 hit.
PROSITE	PS00163. FUMARATE_LYASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARLY_ANOFW

Accession

Primary (citable) accession number: B7GGR5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	February 10, 2009
Last modified:	January 25, 2012
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program