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B7GGI5 (MRAY_ANOFW) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 23. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferase
EC=2.7.8.13
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferase
Gene names
Name:mraY
Ordered Locus Names:Aflv_1833
OrganismAnoxybacillus flavithermus (strain DSM 21510 / WK1) [Complete proteome] [HAMAP]
Taxonomic identifier491915 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Anoxybacillus

Protein attributes

Sequence length324 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan By similarity. HAMAP MF_00038

Catalytic activity

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP MF_00038

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00038

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP MF_00038.

Sequence similarities

Belongs to the glycosyltransferase 4 family. MraY subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 324324Phospho-N-acetylmuramoyl-pentapeptide-transferase HAMAP MF_00038
PRO_1000116502

Regions

Transmembrane5 – 2521Helical; Potential
Transmembrane55 – 7521Helical; Potential
Transmembrane81 – 10121Helical; Potential
Transmembrane122 – 14221Helical; Potential
Transmembrane147 – 16721Helical; Potential
Transmembrane176 – 19621Helical; Potential
Transmembrane203 – 22321Helical; Potential
Transmembrane227 – 24721Helical; Potential
Transmembrane250 – 27021Helical; Potential
Transmembrane302 – 32221Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
B7GGI5 [UniParc].

Last modified February 10, 2009. Version 1.
Checksum: D4DC3F59D318378D

FASTA32435,437
        10         20         30         40         50         60 
MNEKVILFTA GLAFIITVVL SPIFIPFLRR LKFGQSIREE GPKSHQKKSG TPTMGGLMIL 

        70         80         90        100        110        120 
LSLSITTWLM SDIFFERTAH TYMLLFVTVG YGLLGFIDDF IKVVMKRNLG LTSKQKLAGQ 

       130        140        150        160        170        180 
LLIALIFYFF FQHYSMSTVV SIPGTDVSLD LGVAYVLLII FMLVGGSNAV NLTDGLDGLL 

       190        200        210        220        230        240 
AGTAAIAFGA YAVLAWNQGQ YDVAIFSVAV VGAVLGFLVF NAHPAKVFMG DTGSLALGGA 

       250        260        270        280        290        300 
IVTIAILTKL EILLVIIGGV FVIETLSVII QVISFKTTGK RVFRMSPLHH HYELIGWSEW 

       310        320 
RVVVTFWAVG LLFAILGIYI EVWV

« Hide

References

[1]"Encapsulated in silica: genome, proteome and physiology of the thermophilic bacterium Anoxybacillus flavithermus WK1."
Saw J.H., Mountain B.W., Feng L., Omelchenko M.V., Hou S., Saito J.A., Stott M.B., Li D., Zhao G., Wu J., Galperin M.Y., Koonin E.V., Makarova K.S., Wolf Y.I., Rigden D.J., Dunfield P.F., Wang L., Alam M.
Genome Biol. 9:R161.1-R161.16(2008) [PubMed: 19014707] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 21510 / WK1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000922 Genomic DNA. Translation: ACJ34194.1.
RefSeqYP_002316179.1. NC_011567.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGB7GGI5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7038086.
GenomeReviewsGene locus Aflv_1833 in contig CP000922_GR.
KEGGafl:Aflv_1833.
PATRIC20955553. VBIAnoFla45531_1885.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG708263.
ProtClustDBPRK00108.

Family and domain databases

HAMAPMF_00038. MraY.
[Tree]
InterProIPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
[Graphical view]
KOK01000.
PANTHERPTHR22926. Glyco_trans_4. 1 hit.
PTHR22926:SF3. PNAcPpept_trans. 1 hit.
PfamPF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
[Graphical view]
TIGRFAMsTIGR00445. MraY. 1 hit.
PROSITEPS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMRAY_ANOFW
AccessionPrimary (citable) accession number: B7GGI5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 10, 2009
Last modified: January 25, 2012
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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