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Protein

Histone deacetylase

Gene

PHATRDRAFT_49800

Organism
Phaeodactylum tricornutum (strain CCAP 1055/1)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei97SubstrateUniRule annotation1
Active sitei139Proton acceptorUniRule annotation1
Binding sitei147Substrate; via carbonyl oxygenUniRule annotation1
Metal bindingi174Divalent metal cationUniRule annotation1
Metal bindingi176Divalent metal cationUniRule annotation1
Metal bindingi263Divalent metal cationUniRule annotation1
Binding sitei302SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulatorUniRule annotationSAAS annotation, HydrolaseUniRule annotationSAAS annotation
Biological processTranscription, Transcription regulationUniRule annotationSAAS annotation
LigandMetal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylaseUniRule annotationSAAS annotation (EC:3.5.1.98UniRule annotationSAAS annotation)
Gene namesi
ORF Names:PHATRDRAFT_49800Imported
OrganismiPhaeodactylum tricornutum (strain CCAP 1055/1)Imported
Taxonomic identifieri556484 [NCBI]
Taxonomic lineageiEukaryotaStramenopilesBacillariophytaBacillariophyceaeBacillariophycidaeNaviculalesPhaeodactylaceaePhaeodactylum
Proteomesi
  • UP000000759 Componenti: Chromosome 24

Subcellular locationi

  • Nucleus UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi2850.Phatr49800.

Structurei

3D structure databases

ProteinModelPortaliB7GBY2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 318Hist_deacetylInterPro annotationAdd BLAST295

Sequence similaritiesi

Belongs to the histone deacetylase family. HD Type 1 subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000225180.
InParanoidiB7GBY2.
KOiK06067.
OMAiPRAWTHL.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiView protein in InterPro
IPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiView protein in Pfam
PF00850. Hist_deacetyl. 1 hit.
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.

Sequencei

Sequence statusi: Complete.

B7GBY2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGKSRVSYF YHPTCPLFYY GPSHPMKPHR LKLAHHLILT YGLYKEMDCY
60 70 80 90 100
RPHPAAAGEM TQFHSEDYVN FMSKVTPDNL RQYSASMQRF NAGDSTDCPV
110 120 130 140 150
FDGLFEFTQL YTGSSLDGAL QLCQGNTDIA INWSGGLHHA KKGEASGFCY
160 170 180 190 200
INDIVLAILE LLKVHARVLY VDIDVHHGDG VEEAFYTTDR VMTFSIHKYG
210 220 230 240 250
DFFPGTGHIS DTGAKDGTGF SVNAPLNSGI TDETYFHDLF KPVMEKIMQV
260 270 280 290 300
FNPGAVVLQC GADSLTGDRL GCFNLTLKGH AACVEYVKSF GVPTLVLGGG
310 320 330 340 350
GYTIRNVARC WAYETAVLLD KKDIPNEIPY NDYYEYYAPD YELHLTPTPE
360 370 380 390 400
ENMNGKDALE DVRTELLQQL QDLQGAPSVA MQQVPPSFQR AEATEEDPDV
410 420
REGASKTRSG DGVRKQHPSE LYDEVD
Length:426
Mass (Da):47,486
Last modified:February 10, 2009 - v1
Checksum:i1EBA2C3F0676D525
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000626 Genomic DNA. Translation: EEC43929.1.
RefSeqiXP_002184530.1. XM_002184494.1.
UniGeneiPtc.5458.

Genome annotation databases

EnsemblProtistsiPhatr3_J49800.t1; Phatr3_J49800.p1; Phatr3_J49800.
GeneIDi7198371.
KEGGipti:PHATRDRAFT_49800.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiB7GBY2_PHATC
AccessioniPrimary (citable) accession number: B7GBY2
Entry historyiIntegrated into UniProtKB/TrEMBL: February 10, 2009
Last sequence update: February 10, 2009
Last modified: July 5, 2017
This is version 42 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported