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Protein

Histone deacetylase

Gene

PHATRDRAFT_49800

Organism
Phaeodactylum tricornutum (strain CCAP 1055/1)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotation

GO - Molecular functioni

  1. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
  2. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
  3. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
  4. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, HydrolaseUniRule annotationSAAS annotation

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylaseUniRule annotation (EC:3.5.1.98UniRule annotation)
Gene namesi
ORF Names:PHATRDRAFT_49800Imported
OrganismiPhaeodactylum tricornutum (strain CCAP 1055/1)Imported
Taxonomic identifieri556484 [NCBI]
Taxonomic lineageiEukaryotaStramenopilesBacillariophytaBacillariophyceaeBacillariophycidaeNaviculalesPhaeodactylaceaePhaeodactylum
ProteomesiUP000000759: Chromosome 24

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi2850.JGI49800.

Structurei

3D structure databases

ProteinModelPortaliB7GBY2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone deacetylase family. HD Type 1 subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000225180.
InParanoidiB7GBY2.
KOiK06067.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.

Sequencei

Sequence statusi: Complete.

B7GBY2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTGKSRVSYF YHPTCPLFYY GPSHPMKPHR LKLAHHLILT YGLYKEMDCY
60 70 80 90 100
RPHPAAAGEM TQFHSEDYVN FMSKVTPDNL RQYSASMQRF NAGDSTDCPV
110 120 130 140 150
FDGLFEFTQL YTGSSLDGAL QLCQGNTDIA INWSGGLHHA KKGEASGFCY
160 170 180 190 200
INDIVLAILE LLKVHARVLY VDIDVHHGDG VEEAFYTTDR VMTFSIHKYG
210 220 230 240 250
DFFPGTGHIS DTGAKDGTGF SVNAPLNSGI TDETYFHDLF KPVMEKIMQV
260 270 280 290 300
FNPGAVVLQC GADSLTGDRL GCFNLTLKGH AACVEYVKSF GVPTLVLGGG
310 320 330 340 350
GYTIRNVARC WAYETAVLLD KKDIPNEIPY NDYYEYYAPD YELHLTPTPE
360 370 380 390 400
ENMNGKDALE DVRTELLQQL QDLQGAPSVA MQQVPPSFQR AEATEEDPDV
410 420
REGASKTRSG DGVRKQHPSE LYDEVD
Length:426
Mass (Da):47,486
Last modified:February 10, 2009 - v1
Checksum:i1EBA2C3F0676D525
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000626 Genomic DNA. Translation: EEC43929.1.
RefSeqiXP_002184530.1. XM_002184494.1.
UniGeneiPtc.5458.

Genome annotation databases

EnsemblProtistsiPhatr49800; Phatr49800; Phatr49800.
GeneIDi7198371.
KEGGipti:PHATRDRAFT_49800.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000626 Genomic DNA. Translation: EEC43929.1.
RefSeqiXP_002184530.1. XM_002184494.1.
UniGeneiPtc.5458.

3D structure databases

ProteinModelPortaliB7GBY2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi2850.JGI49800.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiPhatr49800; Phatr49800; Phatr49800.
GeneIDi7198371.
KEGGipti:PHATRDRAFT_49800.

Phylogenomic databases

HOGENOMiHOG000225180.
InParanoidiB7GBY2.
KOiK06067.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The Phaeodactylum genome reveals the evolutionary history of diatom genomes."
    Bowler C., Allen A.E., Badger J.H., Grimwood J., Jabbari K., Kuo A., Maheswari U., Martens C., Maumus F., Otillar R.P., Rayko E., Salamov A., Vandepoele K., Beszteri B., Gruber A., Heijde M., Katinka M., Mock T.
    , Valentin K., Verret F., Berges J.A., Brownlee C., Cadoret J.P., Chiovitti A., Choi C.J., Coesel S., De Martino A., Detter J.C., Durkin C., Falciatore A., Fournet J., Haruta M., Huysman M.J., Jenkins B.D., Jiroutova K., Jorgensen R.E., Joubert Y., Kaplan A., Kroger N., Kroth P.G., La Roche J., Lindquist E., Lommer M., Martin-Jezequel V., Lopez P.J., Lucas S., Mangogna M., McGinnis K., Medlin L.K., Montsant A., Oudot-Le Secq M.P., Napoli C., Obornik M., Parker M.S., Petit J.L., Porcel B.M., Poulsen N., Robison M., Rychlewski L., Rynearson T.A., Schmutz J., Shapiro H., Siaut M., Stanley M., Sussman M.R., Taylor A.R., Vardi A., von Dassow P., Vyverman W., Willis A., Wyrwicz L.S., Rokhsar D.S., Weissenbach J., Armbrust E.V., Green B.R., Van de Peer Y., Grigoriev I.V.
    Nature 456:239-244(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CCAP 1055/1Imported.
  2. Cited for: GENOME REANNOTATION.
    Strain: CCAP 1055/1Imported.

Entry informationi

Entry nameiB7GBY2_PHATC
AccessioniPrimary (citable) accession number: B7GBY2
Entry historyi
Integrated into UniProtKB/TrEMBL: February 10, 2009
Last sequence update: February 10, 2009
Last modified: January 7, 2015
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.