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Protein
Submitted name:

Filamin, alpha

Gene

Flna

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Actin-bindingSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Filamin, alphaImported
Submitted name:
Filamin-AImported
Gene namesi
Name:FlnaImported
ORF Names:RP23-436K3.1-002Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:95556. Flna.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Expressioni

Gene expression databases

BgeeiENSMUSG00000031328.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000098997.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini43 – 149107Actin-bindingInterPro annotationAdd
BLAST
Domaini166 – 266101Actin-bindingInterPro annotationAdd
BLAST

Keywords - Domaini

RepeatSAAS annotation

Phylogenomic databases

eggNOGiKOG0518. Eukaryota.
COG5069. LUCA.
GeneTreeiENSGT00660000095431.
HOGENOMiHOG000044235.
HOVERGENiHBG004163.

Family and domain databases

Gene3Di1.10.418.10. 2 hits.
2.60.40.10. 24 hits.
InterProiIPR001589. Actinin_actin-bd_CS.
IPR001715. CH-domain.
IPR017868. Filamin/ABP280_repeat-like.
IPR001298. Filamin/ABP280_rpt.
IPR028559. FLN_A.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
[Graphical view]
PANTHERiPTHR11915:SF173. PTHR11915:SF173. 1 hit.
PfamiPF00307. CH. 2 hits.
PF00630. Filamin. 23 hits.
[Graphical view]
SMARTiSM00033. CH. 2 hits.
SM00557. IG_FLMN. 24 hits.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF81296. SSF81296. 24 hits.
PROSITEiPS00019. ACTININ_1. 1 hit.
PS00020. ACTININ_2. 1 hit.
PS50021. CH. 2 hits.
PS50194. FILAMIN_REPEAT. 24 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7FAU9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSHSRCGQ SAAVASPGGS IDSRDAEMPA TEKDLAEDAP WKKIQQNTFT
60 70 80 90 100
RWCNEHLKCV SKRIANLQTD LSDGLRLIAL LEVLSQKKMH RKHNQRPTFR
110 120 130 140 150
QMQLENVSVA LEFLDRESIK LVSIDSKAIV DGNLKLILGL IWTLILHYSI
160 170 180 190 200
SMPMWDEEED EEAKKQTPKQ RLLGWIQNKL PQLPITNFSR DWQSGRALGA
210 220 230 240 250
LVDSCAPGLC PDWDSWDASK PVNNAREAMQ QADDWLGIPQ VITPEEIVDP
260 270 280 290 300
NVDEHSVMTY LSQFPKAKLK PGAPLRPKLN PKKARAYGPG IEPTGNMVKK
310 320 330 340 350
RAEFTVETRS AGQGEVLVYV EDPAGHQEEA KVTANNDKNR TFSVWYVPEV
360 370 380 390 400
TGTHKVTVLF AGQHIAKSPF EVYVDKSQGD ASKVTAQGPG LEPSGNIANK
410 420 430 440 450
TTYFEIFTAG AGMGEVEVVI QDPTGQKGTV EPQLEARGDS TYRCSYQPTM
460 470 480 490 500
EGVHTVHVTF AGVPIPRSPY TVTVGQACNP AACRAIGRGL QPKGVRVKET
510 520 530 540 550
ADFKVYTKGA GSGELKVTVK GPKGEERVKQ KDLGDGVYGF EYYPTIPGTY
560 570 580 590 600
TVTITWGGQN IGRSPFEVKV GTECGNQKVR AWGPGLEGGI VGKSADFVVE
610 620 630 640 650
AIGDDVGTLG FSVEGPSQAK IECDDKGDGS CDVRYWPQEA GEYAVHVLCN
660 670 680 690 700
SEDIRLSPFM ADIREAPQDF HPDRVKARGP GLEKTGVAVN KPAEFTVDAK
710 720 730 740 750
HAGKAPLRVQ VQDNEGCSVE ATVKDNGNGT YSCSYVPRKP VKHTAMVSWG
760 770 780 790 800
GVSIPNSPFR VNVGAGSHPN KVKVYGPGVA KTGLKAHEPT YFTVDCTEAG
810 820 830 840 850
QGDVSIGIKC APGVVGPTEA DIDFDIIRND NDTFTVKYTP CGAGSYTIMV
860 870 880 890 900
LFADQATPTS PIRVKVEPSH DASKVKAEGP GLNRTGVELG KPTHFTVNAK
910 920 930 940 950
TAGKGKLDVQ FSGLAKGDAV RDVDIIDHHD NTYTVKYIPV QQGPVGVNVT
960 970 980 990 1000
YGGDHIPKSP FSVGVSPSLD LSKIKVSGLG DKVDVGKDQE FTVKSKGAGG
1010 1020 1030 1040 1050
QGKVASKIVS PSGAAVPCKV EPGLGADNSV VRFVPREEGP YEVEVTYDGV
1060 1070 1080 1090 1100
PVPGSPFPLE AVAPTKPSKV KAFGPGLQGG NAGSPARFTI DTKGAGTGGL
1110 1120 1130 1140 1150
GLTVEGPCEA QLECLDNGDG TCSVSYVPTE PGDYNINILF ADTHIPGSPF
1160 1170 1180 1190 1200
KAHVAPCFDA SKVKCSGPGL ERATAGEVGQ FQVDCSSAGS AELTIEICSE
1210 1220 1230 1240 1250
AGLPAEVYIQ DHGDGTHTIT YIPLCPGAYT VTIKYGGQPV PNFPSKLQVE
1260 1270 1280 1290 1300
PAVDTSGVQC YGPGIEGQGV FREATTEFSV DARALTQTGG PHVKARVANP
1310 1320 1330 1340 1350
SGNLTDTYVQ DCGDGTYKVE YTPYEEGVHS VDVTYDGSPV PSSPFQVPVT
1360 1370 1380 1390 1400
EGCDPSRVRV HGPGIQSGTT NKPNKFTVET RGAGTGGLGL AVEGPSEAKM
1410 1420 1430 1440 1450
SCMDNKDGSC SVEYIPYEAG TYSLNVTYGG HQVPGSPFKV PVHDVTDASK
1460 1470 1480 1490 1500
VKCSGPGLSP GMVRANLPQS FQVDTSKAGV APLQVKVQGP KGLVEPVDVV
1510 1520 1530 1540 1550
DNADGTQTVN YVPSREGSYS ISVLYGEEEV PRSPFKVKVL PTHDASKVKA
1560 1570 1580 1590 1600
SGPGLNTTGV PASLPVEFTI DAKDAGEGLL AVQITDPEGK PKKTHIQDNH
1610 1620 1630 1640 1650
DGTYTVAYVP DVPGRYTILI KYGGDEIPFS PYRVRAVPTG DASKCTVTGA
1660 1670 1680 1690 1700
GIGPTIQIGE ETVITVDTKA AGKGKVTCTV CTPDGSEVDV DVVENEDGTF
1710 1720 1730 1740 1750
DIFYTAPQPG KYVICVRFGG EHVPNSPFQV TALAGDQPTV QTPLRSQQLA
1760 1770 1780 1790 1800
PQYNYPQGSQ QTWIPERPMV GVNGLDVTSL RPFDLVIPFT IKKGEITGEV
1810 1820 1830 1840 1850
RMPSGKVAQP SITDNKDGTV TVRYSPSEAG LHEMDIRYDN MHIPGSPLQF
1860 1870 1880 1890 1900
YVDYVNCGHI TAYGPGLTHG VVNKPATFTV NTKDAGEGGL SLAIEGPSKA
1910 1920 1930 1940 1950
EISCTDNQDG TCSVSYLPVL PGDYSILVKY NDQHIPGSPF TARVTGDDSM
1960 1970 1980 1990 2000
RMSHLKVGSA ADIPINISET DLSLLTATVV PPSGREEPCL LKRLRNGHVG
2010 2020 2030 2040 2050
ISFVPKETGE HLVHVKKNGQ HVASSPIPVV ISQSEIGDAS RVRVSGQGLH
2060 2070 2080 2090 2100
EGHTFEPAEF IIDTRDAGYG GLSLSIEGPS KVDINTEDLE DGTCRVTYCP
2110 2120 2130 2140 2150
TEPGNYIINI KFADQHVPGS PFSVKVTGEG RVKESITRRR RAPSVANIGS
2160 2170 2180 2190 2200
HCDLSLKIPE ISIQDMTAQV TSPSGKTHEA EIVEGENHTY CIRFVPAEMG
2210 2220 2230 2240 2250
MHTVSVKYKG QHVPGSPFQF TVGPLGEGGA HKVRAGGPGL ERAEVGVPAE
2260 2270 2280 2290 2300
FGIWTREAGA GGLAIAVEGP SKAEISFEDR KDGSCGVAYV VQEPGDYEVS
2310 2320 2330 2340 2350
VKFNEEHIPD SPFVVPVASP SGDARRLTVS SLQESGLKVN QPASFAVSLN
2360 2370 2380 2390 2400
GAKGAIDAKV HSPSGALEEC YVTEIDQDKY AVRFIPRENG IYLIDVKFNG
2410 2420 2430 2440 2450
THIPGSPFKI RVGEPGHGGD PGLVSAYGAG LEGGVTGSPA EFIVNTSNAG
2460 2470 2480 2490 2500
AGALSVTIDG PSKVKMDCQE CPEGYRVTYT PMAPGSYLIS IKYGGPYHIG
2510 2520 2530 2540 2550
GSPFKAKVTG PRLVSNHSLH ETSSVFVDSL TKVATVPQHA TSGPGPADVS
2560 2570 2580 2590 2600
KVVAKGLGLS KAYVGQKSNF TVDCSKAGNN MLLVGVHGPR TPCEEILVKH
2610 2620 2630
MGSRLYSVSY LLKDKGEYTL VVKWGDEHIP GSPYRIMVP
Length:2,639
Mass (Da):280,501
Last modified:February 10, 2009 - v1
Checksum:i50AA80AB1A365A59
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL807376 Genomic DNA. Translation: CAT00727.1.
RefSeqiNP_034357.2. NM_010227.3.
XP_011245851.1. XM_011247549.1.
UniGeneiMm.295533.

Genome annotation databases

EnsembliENSMUST00000101454; ENSMUSP00000098997; ENSMUSG00000031328.
ENSMUST00000114299; ENSMUSP00000109938; ENSMUSG00000031328.
GeneIDi192176.
UCSCiuc009tny.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL807376 Genomic DNA. Translation: CAT00727.1.
RefSeqiNP_034357.2. NM_010227.3.
XP_011245851.1. XM_011247549.1.
UniGeneiMm.295533.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000098997.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000101454; ENSMUSP00000098997; ENSMUSG00000031328.
ENSMUST00000114299; ENSMUSP00000109938; ENSMUSG00000031328.
GeneIDi192176.
UCSCiuc009tny.1. mouse.

Organism-specific databases

CTDi2316.
MGIiMGI:95556. Flna.

Phylogenomic databases

eggNOGiKOG0518. Eukaryota.
COG5069. LUCA.
GeneTreeiENSGT00660000095431.
HOGENOMiHOG000044235.
HOVERGENiHBG004163.

Miscellaneous databases

ChiTaRSiFlna. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031328.

Family and domain databases

Gene3Di1.10.418.10. 2 hits.
2.60.40.10. 24 hits.
InterProiIPR001589. Actinin_actin-bd_CS.
IPR001715. CH-domain.
IPR017868. Filamin/ABP280_repeat-like.
IPR001298. Filamin/ABP280_rpt.
IPR028559. FLN_A.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
[Graphical view]
PANTHERiPTHR11915:SF173. PTHR11915:SF173. 1 hit.
PfamiPF00307. CH. 2 hits.
PF00630. Filamin. 23 hits.
[Graphical view]
SMARTiSM00033. CH. 2 hits.
SM00557. IG_FLMN. 24 hits.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF81296. SSF81296. 24 hits.
PROSITEiPS00019. ACTININ_1. 1 hit.
PS00020. ACTININ_2. 1 hit.
PS50021. CH. 2 hits.
PS50194. FILAMIN_REPEAT. 24 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB7FAU9_MOUSE
AccessioniPrimary (citable) accession number: B7FAU9
Entry historyi
Integrated into UniProtKB/TrEMBL: February 10, 2009
Last sequence update: February 10, 2009
Last modified: September 7, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.