B7A1V8 (B7A1V8_ECO57) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Peptide methionine sulfoxide reductase MsrB HAMAP MF_01400
EC=1.8.4.12 HAMAP MF_01400

Alternative name(s):
Peptide-methionine (R)-S-oxide reductase HAMAP MF_01400

Gene names

Name:	msrB HAMAP MF_01400 EMBL EEC26523.1
ORF Names:	ESCCO14588_3999 EMBL EEC26523.1

Organism

Escherichia coli O157:H7 str. TW14588 EMBL EEC26523.1

Taxonomic identifier

502346 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	137 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (R)-S-oxide + thioredoxin. HAMAP MF_01400
Cofactor	Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein By similarity. HAMAP MF_01400
Sequence similarities	Belongs to the MsrB Met sulfoxide reductase family. HAMAP MF_01400

Ontologies

Keywords
Ligand	Metal-binding HAMAP MF_01400 Zinc HAMAP MF_01400
Molecular function	Oxidoreductase HAMAP MF_01400 SAAS SAAS002579 EMBL EEC26523.1
Gene Ontology (GO)
Molecular function	peptide-methionine (R)-S-oxide reductase activity Inferred from electronic annotation. Source: EC peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	118	1	Nucleophile By similarity HAMAP MF_01400
	Metal binding	46	1	Zinc By similarity HAMAP MF_01400
	Metal binding	49	1	Zinc By similarity HAMAP MF_01400
	Metal binding	95	1	Zinc By similarity HAMAP MF_01400
	Metal binding	98	1	Zinc By similarity HAMAP MF_01400

Sequences

	Sequence		Length	Mass (Da)
	B7A1V8 [UniParc]. Last modified February 10, 2009. Version 1. Checksum: 7B9B783DBEBE0F71	FASTA	137	15,451
	10 20 30 40 50 60 MANKPSAEEL KKNLSEMQFY VTQNHGTEPP FTGRLLHNKR DGVYHCLICD APLFHSQTKY 70 80 90 100 110 120 DSGCGWPSFY EPVSEESIRY IKDLSHGMQR IEIRCGNCDA HLGHVFPDGP QPTGERYCVN 130 SASLRFTDGE NGEEING

References

[1]	Sebastian Y., Whittam T.S., Manning S.D., Sutton G. Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: TW14588 EMBL EEC26523.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	ABKY02000004 Genomic DNA. Translation: EEC26523.1.
3D structure databases
ProteinModelPortal	B7A1V8.
SMR	B7A1V8. Positions 3-134.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBESCT00000227289; EBESCP00000210943; EBESCG00000221428.
PATRIC	29406032. VBIEscCol82497_4906.
Phylogenomic databases
OMA	FTDGPVD.
Family and domain databases
HAMAP	MF_01400. MsrB. [Tree]
InterPro	IPR002579. Methionine_sulphoxide_MsrB. IPR011057. Mss4-like. [Graphical view]
Gene3D	G3DSA:2.170.150.20. MsrB. 1 hit.
Pfam	PF01641. SelR. 1 hit. [Graphical view]
SUPFAM	SSF51316. Mss4_like. 1 hit.
TIGRFAMs	TIGR00357. TIGR00357. 1 hit.
ProtoNet	Search...

Entry information

Entry name

B7A1V8_ECO57

Accession

Primary (citable) accession number: B7A1V8

Entry history

Integrated into UniProtKB/TrEMBL:	February 10, 2009
Last sequence update:	February 10, 2009
Last modified:	December 14, 2011
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)