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Protein

Interleukin-1 receptor accessory protein-like 1-B

Gene

il1rapl1b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. During presynaptic differentiation may regulate both synaptic vesicle accumulation in axon terminals and subsequent axon terminal remodeling.1 Publication

GO - Biological processi

  • neuron remodeling Source: ZFIN
  • signal transduction Source: InterPro
  • synapse organization Source: ZFIN
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 receptor accessory protein-like 1-B
Gene namesi
Name:il1rapl1b
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-090109-2. il1rapl1b.

Subcellular locationi

  • Cell membrane By similarity; Single-pass type I membrane protein By similarity
  • Cytoplasm By similarity

  • Note: May localize to the cell body and growth cones of dendrite-like processes.1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 357339ExtracellularSequence analysisAdd
BLAST
Transmembranei358 – 37821HelicalSequence analysisAdd
BLAST
Topological domaini379 – 700322CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • axon terminus Source: ZFIN
  • cytoplasm Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • neuronal cell body Source: ZFIN
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi455 – 4551P → H: Unable to induce axon terminal remodeling. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 700682Interleukin-1 receptor accessory protein-like 1-BPRO_0000390563Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi53 ↔ 118PROSITE-ProRule annotation
Glycosylationi63 – 631N-linked (GlcNAc...)Sequence analysis
Glycosylationi122 – 1221N-linked (GlcNAc...)Sequence analysis
Glycosylationi138 – 1381N-linked (GlcNAc...)Sequence analysis
Disulfide bondi164 ↔ 216PROSITE-ProRule annotation
Glycosylationi213 – 2131N-linked (GlcNAc...)Sequence analysis
Glycosylationi264 – 2641N-linked (GlcNAc...)Sequence analysis
Disulfide bondi267 ↔ 334PROSITE-ProRule annotation
Glycosylationi331 – 3311N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiB6ZK77.

Expressioni

Developmental stagei

Detectable at 24 hpf and gradually increases through development. Detected in the nervous system in olfactory placode, olfactory bulb, telencephalon and tectum.1 Publication

Structurei

3D structure databases

ProteinModelPortaliB6ZK77.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 134103Ig-like C2-type 1Add
BLAST
Domaini143 – 23290Ig-like C2-type 2Add
BLAST
Domaini242 – 350109Ig-like C2-type 3Add
BLAST
Domaini403 – 562160TIRPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni564 – 700137Required for synaptic vesicle accumulation during synaptogenesisAdd
BLAST

Sequence similaritiesi

Belongs to the interleukin-1 receptor family.Curated
Contains 1 TIR domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF3G. Eukaryota.
ENOG4110Z8K. LUCA.
HOVERGENiHBG052148.
InParanoidiB6ZK77.
KOiK05170.
PhylomeDBiB6ZK77.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.40.50.10140. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR015621. IL-1_rcpt_fam.
IPR000157. TIR_dom.
[Graphical view]
PANTHERiPTHR11890. PTHR11890. 1 hit.
PfamiPF01582. TIR. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 2 hits.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS50104. TIR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B6ZK77-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSRVPLQIL LYAAVIRSLK VVSKRGSVDG CTDWSVDYLR YRVLLGEPVR
60 70 80 90 100
IKCALFYGYI RANYTHAQSA GLSLMWYRSA THTDHEEPIT LDGTRTLKEE
110 120 130 140 150
DALWFRPAQL QDSGHYSCVL RNSSYCMKVS MALTVAENSS GLCYNSKMRR
160 170 180 190 200
LEKAELSKSK DILCPDIQDY TPAGSEPHVT WYKECRPKQW RSSIIRTADL
210 220 230 240 250
LSIRDVREDD IGNYTCEIQF GRFLVRRTTE LTVTAPLTDK PPKILQPPEH
260 270 280 290 300
KLSVMELQLG GPVNLTCRAF FGYSGDVSPL IYWMKGEKFI EDLDETRIRE
310 320 330 340 350
SEIKMVREHL GEQEVSVSLT IDSLQEEDLG NYSCYVENGH GRRHAIIQLS
360 370 380 390 400
RRELMYTVEL AGGLGAILLM LIFLVSLYKC YRIELMLFYR NHFGSEDVDG
410 420 430 440 450
ENKDYDAYVS YTKVDPDQWS QETREEEHFA LEILPDMLEK HYGYKLFIPD
460 470 480 490 500
RDLIPTGTYI EDVARCVDQS KRLIIVMTPN YVVRRGWSIF ELETRLRNML
510 520 530 540 550
VSGEIKVILI ECSDLRGIMN YQEVEALKHT IKLLTVIRWP GPGSSKPNSR
560 570 580 590 600
FWKQLQYEMP FRRPEPKLSH EQVLDASEQG PFGELQTVSA LSMVSATSTA
610 620 630 640 650
MATAHPDLRS GFHNTYNTQL RQKHYYRGYE YDIPSSGTLP PLATMGSQHT
660 670 680 690 700
YCNIPMSLLN GQRPPGQPAH GQQQSLEEQQ VNNALLPLLP RETSISSVIW
Length:700
Mass (Da):80,314
Last modified:February 10, 2009 - v1
Checksum:i4871CC6BE227C51A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB449368 mRNA. Translation: BAG85347.1.
RefSeqiNP_001136054.1. NM_001142582.1.
UniGeneiDr.120475.

Genome annotation databases

GeneIDi557801.
KEGGidre:557801.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB449368 mRNA. Translation: BAG85347.1.
RefSeqiNP_001136054.1. NM_001142582.1.
UniGeneiDr.120475.

3D structure databases

ProteinModelPortaliB6ZK77.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiB6ZK77.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi557801.
KEGGidre:557801.

Organism-specific databases

CTDi557801.
ZFINiZDB-GENE-090109-2. il1rapl1b.

Phylogenomic databases

eggNOGiENOG410IF3G. Eukaryota.
ENOG4110Z8K. LUCA.
HOVERGENiHBG052148.
InParanoidiB6ZK77.
KOiK05170.
PhylomeDBiB6ZK77.

Miscellaneous databases

PROiB6ZK77.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.40.50.10140. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR015621. IL-1_rcpt_fam.
IPR000157. TIR_dom.
[Graphical view]
PANTHERiPTHR11890. PTHR11890. 1 hit.
PfamiPF01582. TIR. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 2 hits.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS50104. TIR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Zebrafish orthologue of mental retardation protein IL1RAPL1 regulates presynaptic differentiation."
    Yoshida T., Mishina M.
    Mol. Cell. Neurosci. 39:218-228(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, MUTAGENESIS OF PRO-455.

Entry informationi

Entry nameiIRL1B_DANRE
AccessioniPrimary (citable) accession number: B6ZK77
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 19, 2010
Last sequence update: February 10, 2009
Last modified: June 8, 2016
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.