B6ZGS7 (B6ZGS7_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Liver X receptor beta EMBL BAH02288.1

Gene names

Name:

NR1H2 EMBL BAH02288.1

Organism

Homo sapiens (Human) EMBL BAH02288.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	461 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the nuclear hormone receptor family. RuleBase RU000377 Contains 1 nuclear receptor DNA-binding domain. SAAS SAAS000536

Ontologies

Keywords
Biological process	Transcription Transcription regulation RuleBase RU004334 SAAS SAAS000536
Cellular component	Nucleus RuleBase RU004334 SAAS SAAS000536
Domain	Zinc-finger RuleBase RU004334 SAAS SAAS000536
Ligand	DNA-binding RuleBase RU004334 SAAS SAAS000536 Metal-binding Zinc
Molecular function	Receptor RuleBase RU004334 EMBL BAH02288.1
Gene Ontology (GO)
Biological_process	transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro steroid hormone receptor activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B6ZGS7 [UniParc]. Last modified February 10, 2009. Version 1. Checksum: 376E3865C7FFFF7E	FASTA	461	51,105
	10 20 30 40 50 60 MSSPTTSSLD TPLPGNGPPQ PGAPSSSPTV KEEGPEPWPG GPDPDVPGTD EASSACSTDW 70 80 90 100 110 120 VIPDPEEEPE RKRKKGPAPK MLGHELCRVC GDKASGFHYN VLSCEGCKGF FRRSVVRGGA 130 140 150 160 170 180 RRYACRGGGT CQMDAFMRRK CQQCRLRKCK EAGMREQCVL SEEQIRKKKI RKQQQQESQS 190 200 210 220 230 240 QSQSPVGPQG SSSSASGPGA SPGGSEAGSQ GSGEGEGVQL TAAQELMIQQ LVAAQLQCNK 250 260 270 280 290 300 RSFSDQPKVT PWPLGADPQS RDARQQRFAH FTELAIISVQ EIVDFAKQVP GFLQLGREDQ 310 320 330 340 350 360 IALLMASTIE IMLLETARRY NHETECITFL KDFTYSKDDF HRAGLQVEFI NPIFEFSRAM 370 380 390 400 410 420 RRLGLDDAEY ALLIAINIFS ADRPNVQEPG RVEALQQPYV EALLSYTRIK RPQDQLRFPR 430 440 450 460 MLMKLVSLRT LSSVHSEQVF ALRLQDKKLP PLLSEIWDVH E

References

[1]	Nozawa A., Kobayashi T., Kodani Y., Sawasaki T., Endo Y. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[2]	"Comprehensive DNA-binding analysis of human hormone nuclear receptors by fluorescence correlation spectroscopy based on cell-free system." Kobayashi T., Kodani Y., Sawasaki T., Endo Y. Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB307697 mRNA. Translation: BAH02288.1.
IPI	IPI00967158.
UniGene	Hs.432976.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	B6ZGS7.
Proteomic databases
PRIDE	B6ZGS7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOGENOM	HOG000220845.
HOVERGEN	HBG108655.
Family and domain databases
Gene3D	1.10.565.10. 2 hits. 3.30.50.10. 1 hit.
InterPro	IPR023257. Liver_X_rcpt. IPR008946. Nucl_hormone_rcpt_ligand-bd. IPR000536. Nucl_hrmn_rcpt_lig-bd_core. IPR001723. Str_hrmn_rcpt. IPR001628. Znf_hrmn_rcpt. IPR013088. Znf_NHR/GATA. [Graphical view]
Pfam	PF00104. Hormone_recep. 1 hit. PF00105. zf-C4. 1 hit. [Graphical view]
PRINTS	PR02034. LIVERXRECPTR. PR00398. STRDHORMONER. PR00047. STROIDFINGER.
SMART	SM00430. HOLI. 1 hit. SM00399. ZnF_C4. 1 hit. [Graphical view]
SUPFAM	SSF48508. Str_ncl_receptor. 1 hit.
PROSITE	PS00031. NUCLEAR_REC_DBD_1. 1 hit. PS51030. NUCLEAR_REC_DBD_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	NR1H2. human.
NextBio	35478498.

Entry information

Entry name

B6ZGS7_HUMAN

Accession

Primary (citable) accession number: B6ZGS7

Entry history

Integrated into UniProtKB/TrEMBL:	February 10, 2009
Last sequence update:	February 10, 2009
Last modified:	April 3, 2013
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.