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B6YXD9 (B6YXD9_THEON) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Dihydroorotate dehydrogenase HAMAP MF_00224
Short name=DHOD HAMAP MF_00224
Short name=DHODase HAMAP MF_00224
Short name=DHOdehase HAMAP MF_00224
EC=1.3.-.- HAMAP MF_00224
Gene names
Name:pyrD HAMAP MF_00224
Ordered Locus Names:TON_1264
OrganismThermococcus onnurineus (strain NA1) [Complete proteome] [HAMAP]
Taxonomic identifier523850 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Thermococcus

Protein attributes

Sequence length300 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of dihydroorotate to orotate By similarity. HAMAP MF_00224

Catalytic activity

(S)-dihydroorotate + acceptor = orotate + reduced acceptor. HAMAP MF_00224

Cofactor

Binds 1 FMN per subunit By similarity. HAMAP MF_00224

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway. HAMAP MF_00224

Subcellular location

Cytoplasm By similarity HAMAP MF_00224.

Sequence similarities

Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. HAMAP MF_00224

Ontologies

Keywords
   Biological processPyrimidine biosynthesis HAMAP MF_00224
   Cellular componentCytoplasm HAMAP MF_00224
   LigandFMN HAMAP MF_00224
Flavoprotein HAMAP MF_00224
   Molecular functionOxidoreductase HAMAP MF_00224
   Technical termComplete proteome
Gene Ontology (GO)
   Biological process'de novo' pyrimidine base biosynthetic process

Inferred from electronic annotation. Source: InterPro

UMP biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: HAMAP

   Molecular functiondihydroorotate oxidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site1261Nucleophile By similarity PIRSR PIRSR000164-1

Sequences

Sequence LengthMass (Da)Tools
B6YXD9 [UniParc].

Last modified January 20, 2009. Version 1.
Checksum: DB9D0D12D1823FA4

FASTA30032,352
        10         20         30         40         50         60 
MVRLFVEVAG LKLENPLILA SGVNDKTPEQ WIRAHEEGAG GVVTKSIGIE PRNGYDNPTI 

        70         80         90        100        110        120 
VELPYGLINA MGLPNPGWKG FLEMVEGYTF DFPLIVSIFG GTPEEFAFLA EKLSEVANAF 

       130        140        150        160        170        180 
ELNLSCPHAK GYGMEIGQRP EMVYEVVKAV KDVTDKPVIA KLTPNIDDIT KLGLAAEKAG 

       190        200        210        220        230        240 
ADAVAAINTL KAIAIDVYAR RPILSNRVGG YSGPGVKPVA LRAVYDLAKA LNIPVIGIGG 

       250        260        270        280        290        300 
ITTWRDALEF FLAGARALQI GTAVALRGWK VFREINEGIA RYLEEEGFES IEEIVGLALE

« Hide

References

[1]"The complete genome sequence of Thermococcus onnurineus NA1 reveals a mixed heterotrophic and carboxydotrophic metabolism."
Lee H.S., Kang S.G., Bae S.S., Lim J.K., Cho Y., Kim Y.J., Jeon J.H., Cha S.-S., Kwon K.K., Kim H.-T., Park C.-J., Lee H.-W., Kim S.I., Chun J., Colwell R.R., Kim S.-J., Lee J.-H.
J. Bacteriol. 190:7491-7499(2008) [PubMed: 18790866] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000855 Genomic DNA. Translation: ACJ16752.1.
RefSeqYP_002307649.1. NC_011529.1.

3D structure databases

ProteinModelPortalB6YXD9.
ModBaseSearch...

Protein-protein interaction databases

STRINGB6YXD9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7018289.
GenomeReviewsGene locus TON_1264 in contig CP000855_GR.
KEGGton:TON_1264.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG472415.
OMAHAKGYGM.
ProtClustDBPRK07259.

Family and domain databases

HAMAPMF_00224. DHO_dh_type1.
[Tree]
InterProIPR013785. Aldolase_TIM.
IPR005720. Dihydroorotate_DH.
IPR024920. Dihydroorotate_DH_1.
IPR012135. Dihydroorotate_DH_1_2.
IPR001295. Dihydroorotate_DH_CS.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KOK00226.
PfamPF01180. DHO_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000164. DHO_oxidase. 1 hit.
TIGRFAMsTIGR01037. PyrD_sub1_fam. 1 hit.
PROSITEPS00911. DHODEHASE_1. 1 hit.
PS00912. DHODEHASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB6YXD9_THEON
AccessionPrimary (citable) accession number: B6YXD9
Entry history
Integrated into UniProtKB/TrEMBL: January 20, 2009
Last sequence update: January 20, 2009
Last modified: January 25, 2012
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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