B6YXC8 (RIBL_THEON) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
FAD synthase
EC=2.7.7.2

Alternative name(s):
FMN adenylyltransferase
Flavin adenine dinucleotide synthase

Gene names

Name:	ribL
Ordered Locus Names:	TON_1253

Organism

Thermococcus onnurineus (strain NA1) [Complete proteome] [HAMAP]

Taxonomic identifier

523850 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Thermococcus › Thermococcus onnurineus

Protein attributes

Sequence length	150 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme By similarity. HAMAP-Rule MF_02115
Catalytic activity	ATP + FMN = diphosphate + FAD. HAMAP-Rule MF_02115
Cofactor	Divalent metal cations By similarity.
Pathway	Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1. HAMAP-Rule MF_02115
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the archaeal FAD synthase family.

Ontologies

Keywords
Ligand	ATP-binding FAD FMN Nucleotide-binding
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	FAD biosynthetic process Inferred from electronic annotation. Source: HAMAP FMN metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP FMN adenylyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 150	150	FAD synthase HAMAP-Rule MF_02115		PRO_0000406284
Regions
	Nucleotide binding	16 – 17	2	ATP By similarity
	Nucleotide binding	21 – 24	4	ATP By similarity
	Nucleotide binding	100 – 103	4	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	B6YXC8 [UniParc]. Last modified January 20, 2009. Version 1. Checksum: 14CBA692AB36B201	FASTA	150	17,376
	10 20 30 40 50 60 MEKRERKKIR VLAGGVFDLL HVGHIHFLSQ AKSLGDELVV IVAHDETVRM QKRREPVNPA 70 80 90 100 110 120 EDRAELLRAL KMVDEVYIGS PGTIDYELVR KINPDIVAIG PDQRFSCERL KEELRKHGIN 130 140 150 SEVIRIPYLY KEDRAKTSKI IQRIVETYCE

References

[1]

"The complete genome sequence of Thermococcus onnurineus NA1 reveals a mixed heterotrophic and carboxydotrophic metabolism." Lee H.S., Kang S.G., Bae S.S., Lim J.K., Cho Y., Kim Y.J., Jeon J.H., Cha S.-S., Kwon K.K., Kim H.-T., Park C.-J., Lee H.-W., Kim S.I., Chun J., Colwell R.R., Kim S.-J., Lee J.-H. J. Bacteriol. 190:7491-7499(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NA1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000855 Genomic DNA. Translation: ACJ16741.1.
RefSeq	YP_002307638.1. NC_011529.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	523850.TON_1253.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACJ16741; ACJ16741; TON_1253.
GeneID	7018276.
KEGG	ton:TON_1253.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0615.
HOGENOM	HOG000284153.
KO	K14656.
OMA	VAHDETV.
ProtClustDB	CLSK253517.
Enzyme and pathway databases
UniPathway	UPA00277; UER00407.
Family and domain databases
Gene3D	3.40.50.620. 1 hit.
HAMAP	MF_02115. FAD_synth_arch.
InterPro	IPR004821. Cyt_trans-like. IPR024902. FAD_synth_RibL. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view]
Pfam	PF01467. CTP_transf_2. 1 hit. [Graphical view]
TIGRFAMs	TIGR00125. cyt_tran_rel. 1 hit.
ProtoNet	Search...

Entry information

Entry name

RIBL_THEON

Accession

Primary (citable) accession number: B6YXC8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 5, 2011
Last sequence update:	January 20, 2009
Last modified:	May 1, 2013
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program