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Protein

Glyoxylate reductase

Gene

gyaR

Organism
Thermococcus onnurineus (strain NA1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Glycolate + NAD+ = glyoxylate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei241 – 2411UniRule annotation
Active sitei270 – 2701UniRule annotation
Active sitei288 – 2881Proton donorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi158 – 1614NADPUniRule annotation
Nucleotide bindingi180 – 1823NADPUniRule annotation
Nucleotide bindingi239 – 2413NADPUniRule annotation
Nucleotide bindingi288 – 2903NADPUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-144-MONOMER.
RETL1328306-WGS:GSTH-6753-MONOMER.
TONN523850:GC7X-973-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glyoxylate reductaseUniRule annotation (EC:1.1.1.26UniRule annotation)
Gene namesi
Name:gyaRUniRule annotation
Ordered Locus Names:TON_0945
OrganismiThermococcus onnurineus (strain NA1)
Taxonomic identifieri523850 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
Proteomesi
  • UP000002727 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 334334Glyoxylate reductasePRO_1000201582Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi523850.TON_0945.

Structurei

3D structure databases

ProteinModelPortaliB6YWH0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01755. Archaea.
COG1052. LUCA.
HOGENOMiHOG000136700.
KOiK00015.
OMAiKSIGPDW.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
HAMAPiMF_00776. GyaR.
InterProiIPR006139. D-isomer_2_OHA_DH_cat_dom.
IPR029753. D-isomer_DH_CS.
IPR006140. D-isomer_DH_NAD-bd.
IPR023519. Glyoxylate_reductase_GyaR.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00671. D_2_HYDROXYACID_DH_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B6YWH0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPKVLITRK IPENGIKMLR EHFEVEVWED EHEISREVLL EKVRDVDALV
60 70 80 90 100
TMLSERIDAE VFDAAPRLKI VANYAVGYDN IDIEEATKMG VYITNTPDVL
110 120 130 140 150
TNATADMAWV LLLATARRLI EADKFVRSGE WKKRGVAWHP LMFLGYDVYG
160 170 180 190 200
RTIGIVGFGR IGQAIARRAK GFGMRILYNS RTRKPEVEKE LGAEFMPLDE
210 220 230 240 250
LLKESDFVVL VVPLTKETYH MINEERLKLM KPTAILVNIA RGKVVDTEAL
260 270 280 290 300
VKALREGWIA GAGLDVFEEE PYYHEELFSL DNVVLAPHIG SATYGAREGM
310 320 330
AELVARNLIA FKNGEVPPTL VNREVLNVRK PGFE
Length:334
Mass (Da):37,780
Last modified:January 20, 2009 - v1
Checksum:i19FB2B93FD933EBF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000855 Genomic DNA. Translation: ACJ16433.1.
RefSeqiWP_012571905.1. NC_011529.1.

Genome annotation databases

EnsemblBacteriaiACJ16433; ACJ16433; TON_0945.
GeneIDi7017248.
KEGGiton:TON_0945.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000855 Genomic DNA. Translation: ACJ16433.1.
RefSeqiWP_012571905.1. NC_011529.1.

3D structure databases

ProteinModelPortaliB6YWH0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi523850.TON_0945.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACJ16433; ACJ16433; TON_0945.
GeneIDi7017248.
KEGGiton:TON_0945.

Phylogenomic databases

eggNOGiarCOG01755. Archaea.
COG1052. LUCA.
HOGENOMiHOG000136700.
KOiK00015.
OMAiKSIGPDW.

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-144-MONOMER.
RETL1328306-WGS:GSTH-6753-MONOMER.
TONN523850:GC7X-973-MONOMER.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
HAMAPiMF_00776. GyaR.
InterProiIPR006139. D-isomer_2_OHA_DH_cat_dom.
IPR029753. D-isomer_DH_CS.
IPR006140. D-isomer_DH_NAD-bd.
IPR023519. Glyoxylate_reductase_GyaR.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00671. D_2_HYDROXYACID_DH_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The complete genome sequence of Thermococcus onnurineus NA1 reveals a mixed heterotrophic and carboxydotrophic metabolism."
    Lee H.S., Kang S.G., Bae S.S., Lim J.K., Cho Y., Kim Y.J., Jeon J.H., Cha S.-S., Kwon K.K., Kim H.-T., Park C.-J., Lee H.-W., Kim S.I., Chun J., Colwell R.R., Kim S.-J., Lee J.-H.
    J. Bacteriol. 190:7491-7499(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NA1.

Entry informationi

Entry nameiGYAR_THEON
AccessioniPrimary (citable) accession number: B6YWH0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: January 20, 2009
Last modified: June 8, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.