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Protein

DNA polymerase sliding clamp

Gene

pcn

Organism
Thermococcus onnurineus (strain NA1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processDNA replication

Enzyme and pathway databases

BioCyciTONN523850:G1GAB-857-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase sliding clampUniRule annotation
Alternative name(s):
Proliferating cell nuclear antigen homologUniRule annotation
Short name:
PCNAUniRule annotation
Gene namesi
Name:pcnUniRule annotation
Ordered Locus Names:TON_0826
OrganismiThermococcus onnurineus (strain NA1)
Taxonomic identifieri523850 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
Proteomesi
  • UP000002727 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001158171 – 249DNA polymerase sliding clampAdd BLAST249

Interactioni

Subunit structurei

Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.UniRule annotation

Protein-protein interaction databases

STRINGi523850.TON_0826

Structurei

3D structure databases

SMRiB6YVZ1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PCNA family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00488 Archaea
COG0592 LUCA
HOGENOMiHOG000222371
KOiK04802
OMAiKCANSDD
OrthoDBiPOG093Z0814

Family and domain databases

HAMAPiMF_00317 DNApol_clamp_arch, 1 hit
InterProiView protein in InterPro
IPR000730 Pr_cel_nuc_antig
IPR022649 Pr_cel_nuc_antig_C
IPR022659 Pr_cel_nuc_antig_CS
IPR022648 Pr_cel_nuc_antig_N
PANTHERiPTHR11352:SF0 PTHR11352:SF0, 1 hit
PfamiView protein in Pfam
PF02747 PCNA_C, 1 hit
PF00705 PCNA_N, 1 hit
PRINTSiPR00339 PCNACYCLIN
TIGRFAMsiTIGR00590 pcna, 1 hit
PROSITEiView protein in PROSITE
PS01251 PCNA_1, 1 hit

Sequencei

Sequence statusi: Complete.

B6YVZ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFEIVFDGA KDFADLIATA SNLIDEAAFK ITEEGISMRA MDPSRVVLID
60 70 80 90 100
LNLPESIFSK YEVEEEETVG INMDHFKKIL KRGKNKDTLI LRKGDENFLE
110 120 130 140 150
ITFEGTAKRT FRLPLIEVEE LELDLPELPF TAKVVVLGEV LKEAVKDASL
160 170 180 190 200
VSDALKFIAR ENEFIMKAEG ETNEVEIKLT LEDEGLLDLE VEEETKSAYG
210 220 230 240
ISYLADMIKG IGKADEVIIR FGNEMPLQME YPIRDEGKLI FLLAPRVED
Length:249
Mass (Da):28,138
Last modified:January 20, 2009 - v1
Checksum:i5139271E8F3E4983
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000855 Genomic DNA Translation: ACJ16314.1
RefSeqiWP_012571786.1, NC_011529.1

Genome annotation databases

EnsemblBacteriaiACJ16314; ACJ16314; TON_0826
GeneIDi7017129
KEGGiton:TON_0826
PATRICifig|523850.10.peg.833

Similar proteinsi

Entry informationi

Entry nameiPCNA_THEON
AccessioniPrimary (citable) accession number: B6YVZ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: January 20, 2009
Last modified: March 28, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health