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B6YVS8

- B6YVS8_THEON

UniProt

B6YVS8 - B6YVS8_THEON

Protein

Type 2 DNA topoisomerase 6 subunit A

Gene

top6A

Organism
Thermococcus onnurineus (strain NA1)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 34 (01 Oct 2014)
      Sequence version 1 (20 Jan 2009)
      Previous versions | rss
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    Functioni

    Relaxes both positive and negative superturns and exhibits a strong decatenase activity.UniRule annotation

    Catalytic activityi

    ATP-dependent breakage, passage and rejoining of double-stranded DNA.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei112 – 1121NucleophileUniRule annotation
    Metal bindingi206 – 2061MagnesiumUniRule annotation
    Metal bindingi258 – 2581MagnesiumUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. DNA binding Source: UniProtKB-HAMAP
    3. DNA topoisomerase type II (ATP-hydrolyzing) activity Source: UniProtKB-HAMAP
    4. magnesium ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA topological change Source: UniProtKB-HAMAP
    2. DNA unwinding involved in DNA replication Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase, TopoisomeraseUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, DNA-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciTONN523850:GC7X-791-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Type 2 DNA topoisomerase 6 subunit AUniRule annotation (EC:5.99.1.3UniRule annotation)
    Alternative name(s):
    Type II DNA topoisomerase VI subunit AUniRule annotation
    Gene namesi
    Name:top6AUniRule annotation
    Ordered Locus Names:TON_0763Imported
    OrganismiThermococcus onnurineus (strain NA1)Imported
    Taxonomic identifieri523850 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
    ProteomesiUP000002727: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. chromosome Source: InterPro

    Interactioni

    Subunit structurei

    Homodimer. Heterotetramer of two Top6A and two Top6B chains.UniRule annotation

    Protein-protein interaction databases

    STRINGi523850.TON_0763.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TOP6A family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1697.
    HOGENOMiHOG000225930.
    KOiK03166.
    OMAiENTFEDQ.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    HAMAPiMF_00132. Top6A.
    InterProiIPR002815. Spo11/TopoVI_A.
    IPR013049. Spo11/TopoVI_A_N.
    IPR004085. TopoVI_A.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PANTHERiPTHR10848. PTHR10848. 1 hit.
    PfamiPF04406. TP6A_N. 1 hit.
    [Graphical view]
    PRINTSiPR01550. TOP6AFAMILY.
    PR01552. TPISMRASE6A.
    SUPFAMiSSF56726. SSF56726. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B6YVS8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPKSKAVKRS QPRERFSYDP TKVLNKLEEY GRRVLEDIKS GKNPYFDIPM    50
    RGLSNVYFDE KRRVIKMGDK LSRRYFLNVA HARKFMQTLL IMAYVKRLVS 100
    EGKHASLREA YYANKHTIPG TKENTFEDQR ESDPIIEDLE RMLGVLREEM 150
    HLTADRRGYI YGDIVIRDGE DEFNTSKLGM GGWAVPGTVE HLQFVEVNVD 200
    YALVVETAAM ADRLIEEKFP KKENALIIAT QGQASRGVRR LIHRLHYEEG 250
    LPIIVFTDGD PYGWYIYSTI KQGSINLAYL SEKLATPEAK FVGMTMDDIE 300
    RYGLKNVTEK LKGIPPNKKG GPTGDYKRII EEMNYPWFQN KEWQRQLQLA 350
    LKMGVRIEQQ ALANKSLEFV AKKYLPEKIN NGELLP 386
    Length:386
    Mass (Da):44,621
    Last modified:January 20, 2009 - v1
    Checksum:i31D28C6FD9EC58E7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000855 Genomic DNA. Translation: ACJ16251.1.
    RefSeqiYP_002307148.1. NC_011529.1.

    Genome annotation databases

    EnsemblBacteriaiACJ16251; ACJ16251; TON_0763.
    GeneIDi7017066.
    KEGGiton:TON_0763.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000855 Genomic DNA. Translation: ACJ16251.1 .
    RefSeqi YP_002307148.1. NC_011529.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 523850.TON_0763.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACJ16251 ; ACJ16251 ; TON_0763 .
    GeneIDi 7017066.
    KEGGi ton:TON_0763.

    Phylogenomic databases

    eggNOGi COG1697.
    HOGENOMi HOG000225930.
    KOi K03166.
    OMAi ENTFEDQ.

    Enzyme and pathway databases

    BioCyci TONN523850:GC7X-791-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    HAMAPi MF_00132. Top6A.
    InterProi IPR002815. Spo11/TopoVI_A.
    IPR013049. Spo11/TopoVI_A_N.
    IPR004085. TopoVI_A.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    PANTHERi PTHR10848. PTHR10848. 1 hit.
    Pfami PF04406. TP6A_N. 1 hit.
    [Graphical view ]
    PRINTSi PR01550. TOP6AFAMILY.
    PR01552. TPISMRASE6A.
    SUPFAMi SSF56726. SSF56726. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of Thermococcus onnurineus NA1 reveals a mixed heterotrophic and carboxydotrophic metabolism."
      Lee H.S., Kang S.G., Bae S.S., Lim J.K., Cho Y., Kim Y.J., Jeon J.H., Cha S.-S., Kwon K.K., Kim H.-T., Park C.-J., Lee H.-W., Kim S.I., Chun J., Colwell R.R., Kim S.-J., Lee J.-H.
      J. Bacteriol. 190:7491-7499(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NA1Imported.

    Entry informationi

    Entry nameiB6YVS8_THEON
    AccessioniPrimary (citable) accession number: B6YVS8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 20, 2009
    Last sequence update: January 20, 2009
    Last modified: October 1, 2014
    This is version 34 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3