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B6YVS8 (B6YVS8_THEON) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Type 2 DNA topoisomerase 6 subunit A HAMAP-Rule MF_00132

EC=5.99.1.3 HAMAP-Rule MF_00132
Alternative name(s):
Type II DNA topoisomerase VI subunit A HAMAP-Rule MF_00132
Gene names
Name:top6A HAMAP-Rule MF_00132
Ordered Locus Names:TON_0763 EMBL ACJ16251.1
OrganismThermococcus onnurineus (strain NA1) [Complete proteome] [HAMAP] EMBL ACJ16251.1
Taxonomic identifier523850 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus

Protein attributes

Sequence length386 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Relaxes both positive and negative superturns and exhibits a strong decatenase activity By similarity. HAMAP-Rule MF_00132

Catalytic activity

ATP-dependent breakage, passage and rejoining of double-stranded DNA. HAMAP-Rule MF_00132

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00132

Subunit structure

Homodimer. Heterotetramer of two Top6A and two Top6B chains By similarity. HAMAP-Rule MF_00132

Sequence similarities

Belongs to the TOP6A family. HAMAP-Rule MF_00132

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site1121Nucleophile By similarity HAMAP-Rule MF_00132
Metal binding2061Magnesium By similarity HAMAP-Rule MF_00132
Metal binding2581Magnesium By similarity HAMAP-Rule MF_00132

Sequences

Sequence LengthMass (Da)Tools
B6YVS8 [UniParc].

Last modified January 20, 2009. Version 1.
Checksum: 31D28C6FD9EC58E7

FASTA38644,621
        10         20         30         40         50         60 
MPKSKAVKRS QPRERFSYDP TKVLNKLEEY GRRVLEDIKS GKNPYFDIPM RGLSNVYFDE 

        70         80         90        100        110        120 
KRRVIKMGDK LSRRYFLNVA HARKFMQTLL IMAYVKRLVS EGKHASLREA YYANKHTIPG 

       130        140        150        160        170        180 
TKENTFEDQR ESDPIIEDLE RMLGVLREEM HLTADRRGYI YGDIVIRDGE DEFNTSKLGM 

       190        200        210        220        230        240 
GGWAVPGTVE HLQFVEVNVD YALVVETAAM ADRLIEEKFP KKENALIIAT QGQASRGVRR 

       250        260        270        280        290        300 
LIHRLHYEEG LPIIVFTDGD PYGWYIYSTI KQGSINLAYL SEKLATPEAK FVGMTMDDIE 

       310        320        330        340        350        360 
RYGLKNVTEK LKGIPPNKKG GPTGDYKRII EEMNYPWFQN KEWQRQLQLA LKMGVRIEQQ 

       370        380 
ALANKSLEFV AKKYLPEKIN NGELLP 

« Hide

References

[1]"The complete genome sequence of Thermococcus onnurineus NA1 reveals a mixed heterotrophic and carboxydotrophic metabolism."
Lee H.S., Kang S.G., Bae S.S., Lim J.K., Cho Y., Kim Y.J., Jeon J.H., Cha S.S., Kwon K.K., Kim H.T., Park C.J., Lee H.W., Kim S.I., Chun J., Colwell R.R., Kim S.J., Lee J.H.
J. Bacteriol. 190:7491-7499(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NA1 EMBL ACJ16251.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000855 Genomic DNA. Translation: ACJ16251.1.
RefSeqYP_002307148.1. NC_011529.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING523850.TON_0763.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACJ16251; ACJ16251; TON_0763.
GeneID7017066.
KEGGton:TON_0763.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1697.
HOGENOMHOG000225930.
KOK03166.
OMAENTFEDQ.
ProtClustDBPRK04342.

Enzyme and pathway databases

BioCycTONN523850:GC7X-791-MONOMER.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
HAMAPMF_00132. Top6A.
InterProIPR002815. Spo11/TopoVI_A.
IPR013049. Spo11/TopoVI_A_N.
IPR004085. TopoVI_A.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERPTHR10848. PTHR10848. 1 hit.
PfamPF04406. TP6A_N. 1 hit.
[Graphical view]
PRINTSPR01550. TOP6AFAMILY.
PR01552. TPISMRASE6A.
SUPFAMSSF56726. SSF56726. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB6YVS8_THEON
AccessionPrimary (citable) accession number: B6YVS8
Entry history
Integrated into UniProtKB/TrEMBL: January 20, 2009
Last sequence update: January 20, 2009
Last modified: April 16, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)