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B6YVS8

- B6YVS8_THEON

UniProt

B6YVS8 - B6YVS8_THEON

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Protein
Type 2 DNA topoisomerase 6 subunit A
Gene
top6A, TON_0763
Organism
Thermococcus onnurineus (strain NA1)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Relaxes both positive and negative superturns and exhibits a strong decatenase activity By similarity.UniRule annotation

Catalytic activityi

ATP-dependent breakage, passage and rejoining of double-stranded DNA.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei112 – 1121Nucleophile By similarityUniRule annotation
Metal bindingi206 – 2061Magnesium By similarityUniRule annotation
Metal bindingi258 – 2581Magnesium By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: UniProtKB-HAMAP
  3. DNA topoisomerase type II (ATP-hydrolyzing) activity Source: UniProtKB-HAMAP
  4. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA topological change Source: UniProtKB-HAMAP
  2. DNA unwinding involved in DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, TopoisomeraseUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, DNA-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciTONN523850:GC7X-791-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Type 2 DNA topoisomerase 6 subunit AUniRule annotation (EC:5.99.1.3UniRule annotation)
Alternative name(s):
Type II DNA topoisomerase VI subunit A
Gene namesi
Name:top6AUniRule annotation
Ordered Locus Names:TON_0763Imported
OrganismiThermococcus onnurineus (strain NA1)Imported
Taxonomic identifieri523850 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
ProteomesiUP000002727: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. chromosome Source: InterPro
Complete GO annotation...

Interactioni

Subunit structurei

Homodimer. Heterotetramer of two Top6A and two Top6B chains By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi523850.TON_0763.

Family & Domainsi

Sequence similaritiesi

Belongs to the TOP6A family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1697.
HOGENOMiHOG000225930.
KOiK03166.
OMAiENTFEDQ.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
HAMAPiMF_00132. Top6A.
InterProiIPR002815. Spo11/TopoVI_A.
IPR013049. Spo11/TopoVI_A_N.
IPR004085. TopoVI_A.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR10848. PTHR10848. 1 hit.
PfamiPF04406. TP6A_N. 1 hit.
[Graphical view]
PRINTSiPR01550. TOP6AFAMILY.
PR01552. TPISMRASE6A.
SUPFAMiSSF56726. SSF56726. 1 hit.

Sequencei

Sequence statusi: Complete.

B6YVS8-1 [UniParc]FASTAAdd to Basket

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MPKSKAVKRS QPRERFSYDP TKVLNKLEEY GRRVLEDIKS GKNPYFDIPM    50
RGLSNVYFDE KRRVIKMGDK LSRRYFLNVA HARKFMQTLL IMAYVKRLVS 100
EGKHASLREA YYANKHTIPG TKENTFEDQR ESDPIIEDLE RMLGVLREEM 150
HLTADRRGYI YGDIVIRDGE DEFNTSKLGM GGWAVPGTVE HLQFVEVNVD 200
YALVVETAAM ADRLIEEKFP KKENALIIAT QGQASRGVRR LIHRLHYEEG 250
LPIIVFTDGD PYGWYIYSTI KQGSINLAYL SEKLATPEAK FVGMTMDDIE 300
RYGLKNVTEK LKGIPPNKKG GPTGDYKRII EEMNYPWFQN KEWQRQLQLA 350
LKMGVRIEQQ ALANKSLEFV AKKYLPEKIN NGELLP 386
Length:386
Mass (Da):44,621
Last modified:January 20, 2009 - v1
Checksum:i31D28C6FD9EC58E7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000855 Genomic DNA. Translation: ACJ16251.1.
RefSeqiYP_002307148.1. NC_011529.1.

Genome annotation databases

EnsemblBacteriaiACJ16251; ACJ16251; TON_0763.
GeneIDi7017066.
KEGGiton:TON_0763.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000855 Genomic DNA. Translation: ACJ16251.1 .
RefSeqi YP_002307148.1. NC_011529.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 523850.TON_0763.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACJ16251 ; ACJ16251 ; TON_0763 .
GeneIDi 7017066.
KEGGi ton:TON_0763.

Phylogenomic databases

eggNOGi COG1697.
HOGENOMi HOG000225930.
KOi K03166.
OMAi ENTFEDQ.

Enzyme and pathway databases

BioCyci TONN523850:GC7X-791-MONOMER.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
HAMAPi MF_00132. Top6A.
InterProi IPR002815. Spo11/TopoVI_A.
IPR013049. Spo11/TopoVI_A_N.
IPR004085. TopoVI_A.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
PANTHERi PTHR10848. PTHR10848. 1 hit.
Pfami PF04406. TP6A_N. 1 hit.
[Graphical view ]
PRINTSi PR01550. TOP6AFAMILY.
PR01552. TPISMRASE6A.
SUPFAMi SSF56726. SSF56726. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Thermococcus onnurineus NA1 reveals a mixed heterotrophic and carboxydotrophic metabolism."
    Lee H.S., Kang S.G., Bae S.S., Lim J.K., Cho Y., Kim Y.J., Jeon J.H., Cha S.S., Kwon K.K., Kim H.T., Park C.J., Lee H.W., Kim S.I., Chun J., Colwell R.R., Kim S.J., Lee J.H.
    J. Bacteriol. 190:7491-7499(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NA1Imported.

Entry informationi

Entry nameiB6YVS8_THEON
AccessioniPrimary (citable) accession number: B6YVS8
Entry historyi
Integrated into UniProtKB/TrEMBL: January 20, 2009
Last sequence update: January 20, 2009
Last modified: June 11, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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