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Protein

Pyrrolidone-carboxylate peptidase

Gene

pcp

Organism
Thermococcus onnurineus (strain NA1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Removes 5-oxoproline from various penultimate amino acid residues except L-proline.UniRule annotation

Catalytic activityi

Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei78UniRule annotation1
Active sitei141UniRule annotation1
Active sitei165UniRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Protein family/group databases

MEROPSiC15.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyrrolidone-carboxylate peptidaseUniRule annotation (EC:3.4.19.3UniRule annotation)
Alternative name(s):
5-oxoprolyl-peptidaseUniRule annotation
Pyroglutamyl-peptidase IUniRule annotation
Short name:
PGP-IUniRule annotation
Short name:
PyraseUniRule annotation
Gene namesi
Name:pcpUniRule annotation
Ordered Locus Names:TON_1690
OrganismiThermococcus onnurineus (strain NA1)
Taxonomic identifieri523850 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
Proteomesi
  • UP000002727 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001240051 – 200Pyrrolidone-carboxylate peptidaseAdd BLAST200

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi523850.TON_1690.

Structurei

3D structure databases

ProteinModelPortaliB6YUJ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C15 family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG05850. Archaea.
COG2039. LUCA.
HOGENOMiHOG000242641.
KOiK01304.
OMAiVCNHIMY.

Family and domain databases

CDDicd00501. Peptidase_C15. 1 hit.
Gene3Di3.40.630.20. 1 hit.
HAMAPiMF_00417. Pyrrolid_peptidase. 1 hit.
InterProiIPR000816. Peptidase_C15.
IPR016125. Peptidase_C15-like.
IPR029762. PGP-I_bact-type.
IPR033694. PGPEP1_Cys_AS.
IPR033693. PGPEP1_Glu_AS.
[Graphical view]
PANTHERiPTHR23402. PTHR23402. 1 hit.
PfamiPF01470. Peptidase_C15. 1 hit.
[Graphical view]
PIRSFiPIRSF015592. Prld-crbxl_pptds. 1 hit.
PRINTSiPR00706. PYROGLUPTASE.
TIGRFAMsiTIGR00504. pyro_pdase. 1 hit.
PROSITEiPS01334. PYRASE_CYS. 1 hit.
PS01333. PYRASE_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B6YUJ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVLITGFEP FGGEEINPSW EAVRRLPDEI AGAELIKRQL PVTFRGVREL
60 70 80 90 100
LPRLIVETKP DLVILTGQAG GRPNITVERV AINVMDSTMP DNEGYTPEDE
110 120 130 140 150
PIFEGAPDAY FATLPIKAIV KALREAKIPA AVSNTAGTYV CNTAMYTVLH
160 170 180 190 200
TIAVAGMETK AGFIHVPFIH EQALDKPRPS MALETVVKAY EVIIKTSLKA
Length:200
Mass (Da):21,840
Last modified:January 20, 2009 - v1
Checksum:iE43E4703FB4A9DB1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000855 Genomic DNA. Translation: ACJ17180.1.
RefSeqiWP_012572652.1. NC_011529.1.

Genome annotation databases

EnsemblBacteriaiACJ17180; ACJ17180; TON_1690.
GeneIDi7017359.
KEGGiton:TON_1690.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000855 Genomic DNA. Translation: ACJ17180.1.
RefSeqiWP_012572652.1. NC_011529.1.

3D structure databases

ProteinModelPortaliB6YUJ5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi523850.TON_1690.

Protein family/group databases

MEROPSiC15.001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACJ17180; ACJ17180; TON_1690.
GeneIDi7017359.
KEGGiton:TON_1690.

Phylogenomic databases

eggNOGiarCOG05850. Archaea.
COG2039. LUCA.
HOGENOMiHOG000242641.
KOiK01304.
OMAiVCNHIMY.

Family and domain databases

CDDicd00501. Peptidase_C15. 1 hit.
Gene3Di3.40.630.20. 1 hit.
HAMAPiMF_00417. Pyrrolid_peptidase. 1 hit.
InterProiIPR000816. Peptidase_C15.
IPR016125. Peptidase_C15-like.
IPR029762. PGP-I_bact-type.
IPR033694. PGPEP1_Cys_AS.
IPR033693. PGPEP1_Glu_AS.
[Graphical view]
PANTHERiPTHR23402. PTHR23402. 1 hit.
PfamiPF01470. Peptidase_C15. 1 hit.
[Graphical view]
PIRSFiPIRSF015592. Prld-crbxl_pptds. 1 hit.
PRINTSiPR00706. PYROGLUPTASE.
TIGRFAMsiTIGR00504. pyro_pdase. 1 hit.
PROSITEiPS01334. PYRASE_CYS. 1 hit.
PS01333. PYRASE_GLU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPCP_THEON
AccessioniPrimary (citable) accession number: B6YUJ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: January 20, 2009
Last modified: November 2, 2016
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.