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Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Thermococcus onnurineus (strain NA1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTONN523850:G1GAB-1716-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetaseUniRule annotation
Short name:
TrpRSUniRule annotation
Gene namesi
Name:trpSUniRule annotation
Ordered Locus Names:TON_1666
OrganismiThermococcus onnurineus (strain NA1)
Taxonomic identifieri523850 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
Proteomesi
  • UP000002727 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000961141 – 384Tryptophan--tRNA ligaseAdd BLAST384

Interactioni

Protein-protein interaction databases

STRINGi523850.TON_1666

Structurei

3D structure databases

SMRiB6YUH1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi81 – 89"HIGH" region9
Motifi252 – 256"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01887 Archaea
COG0180 LUCA
HOGENOMiHOG000224742
KOiK01867
OMAiADILHPQ
OrthoDBiPOG093Z034D

Family and domain databases

CDDicd00806 TrpRS_core, 1 hit
Gene3Di3.40.50.6201 hit
HAMAPiMF_00140_A Trp_tRNA_synth_A, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002305 aa-tRNA-synth_Ic
IPR014729 Rossmann-like_a/b/a_fold
IPR002306 Trp-tRNA-ligase
IPR020653 Tryptophan-tRNA-ligase_arc
PfamiView protein in Pfam
PF00579 tRNA-synt_1b, 1 hit
PRINTSiPR01039 TRNASYNTHTRP
TIGRFAMsiTIGR00233 trpS, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

B6YUH1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEFKVTPWD VEGLVDYNKL IEEFGTSPLT DELLEKTAQL TKSELPLYFR
60 70 80 90 100
RRFFFSHRDY DKVLQDYESG KGFFLYTGRG PSGPMHIGHI IPFFATKWLQ
110 120 130 140 150
EKFGVNLYIQ ITDDEKFLFK DKLTFEDTKY WAYQNILDII AVGFDPDRTF
160 170 180 190 200
IFQDSEFTKI YEMAIPIAKK INFSMAKAVF GFTEQSKIGM IFYPAIQAAP
210 220 230 240 250
TFFEKKRCLI PAAIDQDPYW RLQRDFAESL GYYKTAAIHS KFVPGLMGLE
260 270 280 290 300
GKMSASKPET AIYLTDDPEE VGRKIWKYAL TGGRATAKEQ REKGGEPEKC
310 320 330 340 350
VVFKWLEIFF EEDDKKLMER YHACKNGELL CGQCKRYLIK KVQEFLKEHQ
360 370 380
KKRKEAEKKV EKFKYTGELA REQWDKAVPE ALKG
Length:384
Mass (Da):44,884
Last modified:January 20, 2009 - v1
Checksum:iF51516595CC2B64C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000855 Genomic DNA Translation: ACJ17156.1
RefSeqiWP_012572628.1, NC_011529.1

Genome annotation databases

EnsemblBacteriaiACJ17156; ACJ17156; TON_1666
GeneIDi7017335
KEGGiton:TON_1666
PATRICifig|523850.10.peg.1679

Similar proteinsi

Entry informationi

Entry nameiSYW_THEON
AccessioniPrimary (citable) accession number: B6YUH1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: January 20, 2009
Last modified: March 28, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome