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B6YUH1

- SYW_THEON

UniProt

B6YUH1 - SYW_THEON

Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Thermococcus onnurineus (strain NA1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 34 (01 Oct 2014)
      Sequence version 1 (20 Jan 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. tryptophan-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. tryptophanyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciTONN523850:GC7X-1716-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
    Alternative name(s):
    Tryptophanyl-tRNA synthetaseUniRule annotation
    Short name:
    TrpRSUniRule annotation
    Gene namesi
    Name:trpSUniRule annotation
    Ordered Locus Names:TON_1666
    OrganismiThermococcus onnurineus (strain NA1)
    Taxonomic identifieri523850 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
    ProteomesiUP000002727: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 384384Tryptophan--tRNA ligasePRO_1000096114Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi523850.TON_1666.

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi81 – 899"HIGH" region
    Motifi252 – 2565"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0180.
    HOGENOMiHOG000224742.
    KOiK01867.
    OMAiKTFIFNN.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    HAMAPiMF_00140_A. Trp_tRNA_synth_A.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002305. aa-tRNA-synth_Ic.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR002306. Trp-tRNA-ligase.
    IPR020653. Tryptophan-tRNA-ligase_arc.
    [Graphical view]
    PANTHERiPTHR10055. PTHR10055. 1 hit.
    PfamiPF00579. tRNA-synt_1b. 1 hit.
    [Graphical view]
    PRINTSiPR01039. TRNASYNTHTRP.
    TIGRFAMsiTIGR00233. trpS. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B6YUH1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDEFKVTPWD VEGLVDYNKL IEEFGTSPLT DELLEKTAQL TKSELPLYFR    50
    RRFFFSHRDY DKVLQDYESG KGFFLYTGRG PSGPMHIGHI IPFFATKWLQ 100
    EKFGVNLYIQ ITDDEKFLFK DKLTFEDTKY WAYQNILDII AVGFDPDRTF 150
    IFQDSEFTKI YEMAIPIAKK INFSMAKAVF GFTEQSKIGM IFYPAIQAAP 200
    TFFEKKRCLI PAAIDQDPYW RLQRDFAESL GYYKTAAIHS KFVPGLMGLE 250
    GKMSASKPET AIYLTDDPEE VGRKIWKYAL TGGRATAKEQ REKGGEPEKC 300
    VVFKWLEIFF EEDDKKLMER YHACKNGELL CGQCKRYLIK KVQEFLKEHQ 350
    KKRKEAEKKV EKFKYTGELA REQWDKAVPE ALKG 384
    Length:384
    Mass (Da):44,884
    Last modified:January 20, 2009 - v1
    Checksum:iF51516595CC2B64C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000855 Genomic DNA. Translation: ACJ17156.1.
    RefSeqiYP_002308053.1. NC_011529.1.

    Genome annotation databases

    EnsemblBacteriaiACJ17156; ACJ17156; TON_1666.
    GeneIDi7017335.
    KEGGiton:TON_1666.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000855 Genomic DNA. Translation: ACJ17156.1 .
    RefSeqi YP_002308053.1. NC_011529.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 523850.TON_1666.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACJ17156 ; ACJ17156 ; TON_1666 .
    GeneIDi 7017335.
    KEGGi ton:TON_1666.

    Phylogenomic databases

    eggNOGi COG0180.
    HOGENOMi HOG000224742.
    KOi K01867.
    OMAi KTFIFNN.

    Enzyme and pathway databases

    BioCyci TONN523850:GC7X-1716-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    HAMAPi MF_00140_A. Trp_tRNA_synth_A.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002305. aa-tRNA-synth_Ic.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR002306. Trp-tRNA-ligase.
    IPR020653. Tryptophan-tRNA-ligase_arc.
    [Graphical view ]
    PANTHERi PTHR10055. PTHR10055. 1 hit.
    Pfami PF00579. tRNA-synt_1b. 1 hit.
    [Graphical view ]
    PRINTSi PR01039. TRNASYNTHTRP.
    TIGRFAMsi TIGR00233. trpS. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of Thermococcus onnurineus NA1 reveals a mixed heterotrophic and carboxydotrophic metabolism."
      Lee H.S., Kang S.G., Bae S.S., Lim J.K., Cho Y., Kim Y.J., Jeon J.H., Cha S.-S., Kwon K.K., Kim H.-T., Park C.-J., Lee H.-W., Kim S.I., Chun J., Colwell R.R., Kim S.-J., Lee J.-H.
      J. Bacteriol. 190:7491-7499(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NA1.

    Entry informationi

    Entry nameiSYW_THEON
    AccessioniPrimary (citable) accession number: B6YUH1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: January 20, 2009
    Last modified: October 1, 2014
    This is version 34 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3