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B6YTR4

- B6YTR4_THEON

UniProt

B6YTR4 - B6YTR4_THEON

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Protein
DNA ligase
Gene
lig, TON_1515
Organism
Thermococcus onnurineus (strain NA1)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei250 – 2501ATP By similarityUniRule annotation
Active sitei252 – 2521N6-AMP-lysine intermediate By similarityUniRule annotation
Binding sitei257 – 2571ATP By similarityUniRule annotation
Binding sitei272 – 2721ATP By similarityUniRule annotation
Binding sitei302 – 3021ATP By similarityUniRule annotation
Binding sitei342 – 3421ATP By similarityUniRule annotation
Binding sitei417 – 4171ATP By similarityUniRule annotation
Binding sitei423 – 4231ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. DNA ligation involved in DNA repair Source: InterPro
  2. DNA recombination Source: UniProtKB-HAMAP
  3. DNA replication Source: UniProtKB-HAMAP
  4. cell cycle Source: UniProtKB-KW
  5. cell division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciTONN523850:GC7X-1562-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:TON_1515Imported
OrganismiThermococcus onnurineus (strain NA1)Imported
Taxonomic identifieri523850 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
ProteomesiUP000002727: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi523850.TON_1515.

Structurei

3D structure databases

ProteinModelPortaliB6YTR4.
SMRiB6YTR4. Positions 4-561.

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1793.
HOGENOMiHOG000036008.
KOiK10747.
OMAiARVQVHK.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B6YTR4-1 [UniParc]FASTAAdd to Basket

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MGDMKYTELS DLYRRLEKTT LKTLKTKFVA DFLKKTPDEL LEVVPYLILG    50
KVFPDWDERE LGVGEKLLIK AVSMATGVQE REIENSVKDT GDLGESVALA 100
LKKKKQKSFF SQPLTIKRVY QTFIKIAEAS GEGSQDRKLK YLANIFMDAQ 150
PEEGKYIART VLGMMRTGVA EGILRDAIAE AFKVKAELVE RAYMLTSDFG 200
YVAKVAKLEG NDGLGKVHIQ IGKPIRPMLA QNAASVKEAL LEMGAEAAFE 250
IKYDGARVQV HKDGDRVVIY SRRLENVTRS IPEVVDAIKA SIKSEKAIVE 300
GELVAVGEGG RPRPFQYVLR RFRRKYNIEE MIEKIPLELN LFDVLYVDGE 350
PLIDTPFRER RAKLEEIVEE GEKLKLAQQL VTKKVEEAEE FYKKALELGH 400
EGLMAKRLDS VYEPGNRGKK WLKIKPTMED LDLVIIGAEW GEGRRAHLLG 450
SFLVAAYDPH SGEFVPVGKV GSGFTDEDLV EFTKMLKPLI IGGEGKFVEI 500
EPKVVIQVTY QEIQKSPKYR SGFALRFPRY VALREDKSPE EADTIERIAQ 550
LYEFQERFKA KK 562
Length:562
Mass (Da):63,655
Last modified:January 20, 2009 - v1
Checksum:iA54BDEB51585437D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000855 Genomic DNA. Translation: ACJ17005.1.
RefSeqiWP_012572477.1. NC_011529.1.
YP_002307902.1. NC_011529.1.

Genome annotation databases

EnsemblBacteriaiACJ17005; ACJ17005; TON_1515.
GeneIDi7018552.
KEGGiton:TON_1515.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000855 Genomic DNA. Translation: ACJ17005.1 .
RefSeqi WP_012572477.1. NC_011529.1.
YP_002307902.1. NC_011529.1.

3D structure databases

ProteinModelPortali B6YTR4.
SMRi B6YTR4. Positions 4-561.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 523850.TON_1515.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACJ17005 ; ACJ17005 ; TON_1515 .
GeneIDi 7018552.
KEGGi ton:TON_1515.

Phylogenomic databases

eggNOGi COG1793.
HOGENOMi HOG000036008.
KOi K10747.
OMAi ARVQVHK.

Enzyme and pathway databases

BioCyci TONN523850:GC7X-1562-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Thermococcus onnurineus NA1 reveals a mixed heterotrophic and carboxydotrophic metabolism."
    Lee H.S., Kang S.G., Bae S.S., Lim J.K., Cho Y., Kim Y.J., Jeon J.H., Cha S.S., Kwon K.K., Kim H.T., Park C.J., Lee H.W., Kim S.I., Chun J., Colwell R.R., Kim S.J., Lee J.H.
    J. Bacteriol. 190:7491-7499(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NA1Imported.

Entry informationi

Entry nameiB6YTR4_THEON
AccessioniPrimary (citable) accession number: B6YTR4
Entry historyi
Integrated into UniProtKB/TrEMBL: January 20, 2009
Last sequence update: January 20, 2009
Last modified: September 3, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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