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B6YT45

- GPI_THEON

UniProt

B6YT45 - GPI_THEON

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Protein
Glucose-6-phosphate isomerase
Gene
pgiA, TON_0247
Organism
Thermococcus onnurineus (strain NA1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi88 – 881Iron By similarity
Metal bindingi90 – 901Iron By similarity
Metal bindingi97 – 971Iron By similarity
Metal bindingi136 – 1361Iron By similarity

GO - Molecular functioni

  1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP
  2. iron ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
  2. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciTONN523850:GC7X-264-MONOMER.
UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
Phosphoglucose isomerase
Short name:
PGI
Phosphohexose isomerase
Short name:
PHI
Gene namesi
Name:pgiA
Ordered Locus Names:TON_0247
OrganismiThermococcus onnurineus (strain NA1)
Taxonomic identifieri523850 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
ProteomesiUP000002727: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 189189Glucose-6-phosphate isomeraseUniRule annotation
PRO_1000145512Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi523850.TON_0247.

Structurei

3D structure databases

ProteinModelPortaliB6YT45.

Family & Domainsi

Sequence similaritiesi

Belongs to the archaeal-type GPI family.

Phylogenomic databases

eggNOGiCOG2140.
HOGENOMiHOG000243903.
KOiK06859.
OMAiYPADAGH.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
HAMAPiMF_01410. G6P_isomerase_arch.
InterProiIPR010551. G6P_isomerase_prok.
IPR016758. G6P_isomerase_subgr.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PfamiPF06560. GPI. 1 hit.
[Graphical view]
PIRSFiPIRSF019325. Glucose-6-phosphate_isomerase. 1 hit.
SUPFAMiSSF51182. SSF51182. 1 hit.

Sequencei

Sequence statusi: Complete.

B6YT45-1 [UniParc]FASTAAdd to Basket

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MEYKAPIGVK IDLETGVIPG AKKLVRRLSD LKGYFIDEEA YNELLREDPV    50
VYEVYAIEQE EKDGDLNFAT TVLYPGKVGK EFFFTKGHYH AKADRAEIYY 100
AIKGKGGMLL QTPEGNAKWV PMEPGTVVYV PPYWAHRTVN TGDEPFIFLA 150
IYPADAGHDY GSIKEKGFSK LVIEEGGEVK VVDNPKWKA 189
Length:189
Mass (Da):21,253
Last modified:January 20, 2009 - v1
Checksum:iB4AE78E487571D65
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000855 Genomic DNA. Translation: ACJ15732.1.
RefSeqiYP_002306629.1. NC_011529.1.

Genome annotation databases

EnsemblBacteriaiACJ15732; ACJ15732; TON_0247.
GeneIDi7017909.
KEGGiton:TON_0247.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000855 Genomic DNA. Translation: ACJ15732.1 .
RefSeqi YP_002306629.1. NC_011529.1.

3D structure databases

ProteinModelPortali B6YT45.
ModBasei Search...

Protein-protein interaction databases

STRINGi 523850.TON_0247.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACJ15732 ; ACJ15732 ; TON_0247 .
GeneIDi 7017909.
KEGGi ton:TON_0247.

Phylogenomic databases

eggNOGi COG2140.
HOGENOMi HOG000243903.
KOi K06859.
OMAi YPADAGH.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00181 .
BioCyci TONN523850:GC7X-264-MONOMER.

Family and domain databases

Gene3Di 2.60.120.10. 1 hit.
HAMAPi MF_01410. G6P_isomerase_arch.
InterProi IPR010551. G6P_isomerase_prok.
IPR016758. G6P_isomerase_subgr.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
Pfami PF06560. GPI. 1 hit.
[Graphical view ]
PIRSFi PIRSF019325. Glucose-6-phosphate_isomerase. 1 hit.
SUPFAMi SSF51182. SSF51182. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Thermococcus onnurineus NA1 reveals a mixed heterotrophic and carboxydotrophic metabolism."
    Lee H.S., Kang S.G., Bae S.S., Lim J.K., Cho Y., Kim Y.J., Jeon J.H., Cha S.-S., Kwon K.K., Kim H.-T., Park C.-J., Lee H.-W., Kim S.I., Chun J., Colwell R.R., Kim S.-J., Lee J.-H.
    J. Bacteriol. 190:7491-7499(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NA1.

Entry informationi

Entry nameiGPI_THEON
AccessioniPrimary (citable) accession number: B6YT45
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: January 20, 2009
Last modified: June 11, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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