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B6YT12

- GCSPB_THEON

UniProt

B6YT12 - GCSPB_THEON

Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene

gcvPB

Organism
Thermococcus onnurineus (strain NA1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (20 Jan 2009)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciTONN523850:GC7X-226-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-protein subunit 2UniRule annotation
    Glycine decarboxylase subunit 2UniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring) subunit 2UniRule annotation
    Gene namesi
    Name:gcvPBUniRule annotation
    Ordered Locus Names:TON_0214
    OrganismiThermococcus onnurineus (strain NA1)
    Taxonomic identifieri523850 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
    ProteomesiUP000002727: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 502502Probable glycine dehydrogenase (decarboxylating) subunit 2PRO_1000132506Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei273 – 2731N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

    Protein-protein interaction databases

    STRINGi523850.TON_0214.

    Structurei

    3D structure databases

    ProteinModelPortaliB6YT12.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family. C-terminal subunit subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239368.
    KOiK00283.
    OMAiWTGLMMI.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    HAMAPiMF_00713. GcvPB.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR023012. GDC_P_su2.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B6YT12-1 [UniParc]FASTAAdd to Basket

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    MFRQAKWDEP LIFELSRSGR VGYTLPKPIE DVEIRVPEKL KRKSPLNLPE    50
    LSEPEVVKHY TRLSGMNYGV DSGIYPLGSC TMKYNPKINE EIAGHPGVAY 100
    VHPYQDERTI QGALKIMWEL EGWLKEITGM DRFTLQPAAG ANGEFTGVMI 150
    IRAYHLDRGE TQRTEMLVPD SAHGTNPASA AMAGFKVIEI PSNENGTVDL 200
    EALENAVSER TAGLMLTNPN TLGIFEDEIL EIAKIVHKAG GLLYYDGANL 250
    NAVLGKIRPG DMGFDIVHLN LHKTFSTPHG GGGPGSGPVG VKDFLKDYLP 300
    VPLVGYDEES GRYYLDYNVP KSIGKVKELY GNFAVMVRAL TYLKIMGRDG 350
    LKEASEIAVL NANYLTQKLK GTRGYELPHK ELRKHEVVFS AEPMKKETGV 400
    KALDVAKRLL DFGLHAPTIY FPLIVHEALM IEPTETVSRE ELDAYVEALK 450
    RISEEAYSNP ELVKSAPHNT AVKRVDDVLA AKRPIITWRM YRELKEKGEV 500
    DI 502
    Length:502
    Mass (Da):55,933
    Last modified:January 20, 2009 - v1
    Checksum:iB57019D41C1E30C8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000855 Genomic DNA. Translation: ACJ15699.1.
    RefSeqiYP_002306596.1. NC_011529.1.

    Genome annotation databases

    EnsemblBacteriaiACJ15699; ACJ15699; TON_0214.
    GeneIDi7017871.
    KEGGiton:TON_0214.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000855 Genomic DNA. Translation: ACJ15699.1 .
    RefSeqi YP_002306596.1. NC_011529.1.

    3D structure databases

    ProteinModelPortali B6YT12.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 523850.TON_0214.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACJ15699 ; ACJ15699 ; TON_0214 .
    GeneIDi 7017871.
    KEGGi ton:TON_0214.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239368.
    KOi K00283.
    OMAi WTGLMMI.

    Enzyme and pathway databases

    BioCyci TONN523850:GC7X-226-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    HAMAPi MF_00713. GcvPB.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR023012. GDC_P_su2.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of Thermococcus onnurineus NA1 reveals a mixed heterotrophic and carboxydotrophic metabolism."
      Lee H.S., Kang S.G., Bae S.S., Lim J.K., Cho Y., Kim Y.J., Jeon J.H., Cha S.-S., Kwon K.K., Kim H.-T., Park C.-J., Lee H.-W., Kim S.I., Chun J., Colwell R.R., Kim S.-J., Lee J.-H.
      J. Bacteriol. 190:7491-7499(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NA1.

    Entry informationi

    Entry nameiGCSPB_THEON
    AccessioniPrimary (citable) accession number: B6YT12
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: January 20, 2009
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3