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B6YSY7 (SYE_THEON) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutamate--tRNA ligase

EC=6.1.1.17
Alternative name(s):
Glutamyl-tRNA synthetase
Short name=GluRS
Gene names
Name:gltX
Ordered Locus Names:TON_0189
OrganismThermococcus onnurineus (strain NA1) [Complete proteome] [HAMAP]
Taxonomic identifier523850 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus

Protein attributes

Sequence length573 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) By similarity. HAMAP-Rule MF_00022

Catalytic activity

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu). HAMAP-Rule MF_00022

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00022.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglutamyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

glutamate-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 573573Glutamate--tRNA ligase HAMAP-Rule MF_00022
PRO_0000367806

Regions

Motif106 – 11611"HIGH" region HAMAP-Rule MF_00022

Sequences

Sequence LengthMass (Da)Tools
B6YSY7 [UniParc].

Last modified January 20, 2009. Version 1.
Checksum: 5111B5733FF636EC

FASTA57366,498
        10         20         30         40         50         60 
MNVEELIMKY ALINAISHKG KANPKAVIGK VLGENPELRP KAKEIIPLVN QIVEQVNGMD 

        70         80         90        100        110        120 
IEEQEAKLKE IYPEFFEAKK EKKEEKKGLP PLPKAEKGKV VTRFAPNPDG AFHLGNARAA 

       130        140        150        160        170        180 
ILSHEYARLY GGKFILRFDD TDPKVKRPEP KFYEWIIEDL KWLGFQIDEI HIASDRLEIY 

       190        200        210        220        230        240 
YKYAEELIKM GKAYVCTCPP EKFRELRDNG IACPHREEPV EVQLERWRKM LNGEYKEGEA 

       250        260        270        280        290        300 
VVRIKTDLKH PNPAVRDWPA LRIIDNPSHP RTGDKYRVWP LYNFASAIDD HELGVTHIFR 

       310        320        330        340        350        360 
GQEHAENETR QRYIYDYFGW EYPVTVHHGR LSIEGVILSK SKTRKGIDEG KYFGWDDPRL 

       370        380        390        400        410        420 
GTIRALKRRG IRPEAIRELI IEVGLKRSDT TISWDNLAAI NRRIVEPIAN RYFFVADPIP 

       430        440        450        460        470        480 
MYIEGYDEEF VAEIPLHPDH PDRGVRKLKF EPGRPVYVSK DDMELFKPGS FVRLKDLFNV 

       490        500        510        520        530        540 
EILEVSEEGI KARFHSIEYE IARENRWRMV HWVTEGRACG VLIPQGDELI VRKGLLESDA 

       550        560        570 
NVKVDDVVQF ERFGFVRIDD VTPEKVVAIF AHK 

« Hide

References

[1]"The complete genome sequence of Thermococcus onnurineus NA1 reveals a mixed heterotrophic and carboxydotrophic metabolism."
Lee H.S., Kang S.G., Bae S.S., Lim J.K., Cho Y., Kim Y.J., Jeon J.H., Cha S.-S., Kwon K.K., Kim H.-T., Park C.-J., Lee H.-W., Kim S.I., Chun J., Colwell R.R., Kim S.-J., Lee J.-H.
J. Bacteriol. 190:7491-7499(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NA1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000855 Genomic DNA. Translation: ACJ15674.1.
RefSeqYP_002306571.1. NC_011529.1.

3D structure databases

ProteinModelPortalB6YSY7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING523850.TON_0189.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACJ15674; ACJ15674; TON_0189.
GeneID7017846.
KEGGton:TON_0189.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0008.
HOGENOMHOG000073585.
KOK01885.
OMAYLGWDDP.

Enzyme and pathway databases

BioCycTONN523850:GC7X-201-MONOMER.

Family and domain databases

Gene3D1.10.1160.10. 1 hit.
2.40.240.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPMF_00022_A. Glu_tRNA_synth_A.
InterProIPR004526. Glu-tRNA-synth_arc/euk.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR022888. Glu_tRNA_synth_arc.
IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERPTHR10119. PTHR10119. 1 hit.
PfamPF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
[Graphical view]
PRINTSPR00987. TRNASYNTHGLU.
SUPFAMSSF50715. SSF50715. 1 hit.
TIGRFAMsTIGR00463. gltX_arch. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSYE_THEON
AccessionPrimary (citable) accession number: B6YSY7
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: January 20, 2009
Last modified: May 14, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries