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Protein

Cell division protein FtsZ

Gene

ftsZ

Organism
Thermococcus onnurineus (strain NA1)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei178GTPUniRule annotation1
Binding sitei182GTPUniRule annotation1
Binding sitei225GTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi60 – 64GTPUniRule annotation5
Nucleotide bindingi147 – 149GTPUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, SeptationUniRule annotation
LigandGTP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division protein FtsZUniRule annotation
Gene namesi
Name:ftsZUniRule annotation
Ordered Locus Names:TON_0176Imported
OrganismiThermococcus onnurineus (strain NA1)Imported
Taxonomic identifieri523850 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
Proteomesi
  • UP000002727 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation
  • Note: Assembles at midcell at the inner surface of the cytoplasmic membrane.UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.UniRule annotation

Protein-protein interaction databases

STRINGi523850.TON_0176

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini52 – 243TubulinInterPro annotationAdd BLAST192
Domaini245 – 361Tubulin_CInterPro annotationAdd BLAST117

Sequence similaritiesi

Belongs to the FtsZ family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG02201 Archaea
COG0206 LUCA
HOGENOMiHOG000049094
KOiK03531
OMAiMRAVKGI
OrthoDBiPOG093Z0942

Family and domain databases

CDDicd02201 FtsZ_type1, 1 hit
Gene3Di3.30.1330.20, 1 hit
3.40.50.1440, 1 hit
HAMAPiMF_00909 FtsZ, 1 hit
InterProiView protein in InterPro
IPR000158 Cell_div_FtsZ
IPR020805 Cell_div_FtsZ_CS
IPR024757 FtsZ_C
IPR008280 Tub_FtsZ_C
IPR018316 Tubulin/FtsZ_2-layer-sand-dom
IPR037103 Tubulin/FtsZ_C_sf
IPR036525 Tubulin/FtsZ_GTPase_sf
IPR003008 Tubulin_FtsZ_GTPase
PfamiView protein in Pfam
PF12327 FtsZ_C, 1 hit
PF00091 Tubulin, 1 hit
PRINTSiPR00423 CELLDVISFTSZ
SMARTiView protein in SMART
SM00864 Tubulin, 1 hit
SM00865 Tubulin_C, 1 hit
SUPFAMiSSF52490 SSF52490, 1 hit
SSF55307 SSF55307, 1 hit
TIGRFAMsiTIGR00065 ftsZ, 1 hit
PROSITEiView protein in PROSITE
PS01134 FTSZ_1, 1 hit
PS01135 FTSZ_2, 1 hit

Sequencei

Sequence statusi: Complete.

B6YSX4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNCPEGEKM LKLIEDAIER TSSDLNKVPE AQAPQTDIDE ELRRILEQIQ
60 70 80 90 100
AKIYVIGVGG AGCNTINRMM QVGIQGAKVI AINTDAQDLL KVRAHKKILI
110 120 130 140 150
GKELTRGLGA GNNPKMGEEA AKESEREIRD ALEGADMVFI TCGLGGGTGT
160 170 180 190 200
GAAPVVAEIA KKMGALTVSV VTLPFTVEGI RRIKNAEYGL ERLRKNSDTV
210 220 230 240 250
IVIPNDKLME VAPNLPIHMA FKVADEILVQ AVKGITELIT KPGLVNLDFN
260 270 280 290 300
DVRAVMKDGG VAMIGIGESD SEKRALEAAQ QALNSPLLDV DISGAKGALI
310 320 330 340 350
SISGSDVKLE EAQQIIELVT SKLDPEAQVI WGIQLDEELG KMIRILIVVT
360 370 380
GVSSPYAVAE EEPTYYGEEP ERKVIKLDLE EL
Length:382
Mass (Da):41,154
Last modified:January 20, 2009 - v1
Checksum:i9D80FB1D57EE0C87
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000855 Genomic DNA Translation: ACJ15661.1

Genome annotation databases

EnsemblBacteriaiACJ15661; ACJ15661; TON_0176
KEGGiton:TON_0176
PATRICifig|523850.10.peg.176

Similar proteinsi

Entry informationi

Entry nameiB6YSX4_THEON
AccessioniPrimary (citable) accession number: B6YSX4
Entry historyiIntegrated into UniProtKB/TrEMBL: January 20, 2009
Last sequence update: January 20, 2009
Last modified: March 28, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health