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B6YST9

- SYL_THEON

UniProt

B6YST9 - SYL_THEON

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Protein
Leucine--tRNA ligase
Gene
leuS, TON_0141
Organism
Thermococcus onnurineus (strain NA1)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei653 – 6531ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTONN523850:GC7X-150-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:TON_0141
OrganismiThermococcus onnurineus (strain NA1)
Taxonomic identifieri523850 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
ProteomesiUP000002727: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 967967Leucine--tRNA ligaseUniRule annotation
PRO_1000199235Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi523850.TON_0141.

Structurei

3D structure databases

ProteinModelPortaliB6YST9.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi43 – 5311"HIGH" regionUniRule annotation
Add
BLAST
Motifi650 – 6545"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000216620.
KOiK01869.
OMAiYSKFVEW.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_A. Leu_tRNA_synth_A.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsiTIGR00395. leuS_arch. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B6YST9-1 [UniParc]FASTAAdd to Basket

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MAELNFKAIE EKWQKRWMED RVFEPDRNAK PKEKKFYITV AFPYLSGHLH    50
VGHARTYTIP DVIARFKRMQ GYNVLFPMAW HITGAPIVGI AERIKNRDPK 100
TIHIYRDVYK VPEEILWKFE DPKEIVKYFM KAARETFIRA GFSVDWSREF 150
HTTSLFPPFS KFIEWQFWTL KDMGLVVKGA HRVRWDPVVG TPLGDHDIME 200
GEDVQILEYV IIKFILEENG EEIYMPAATL RPETVYGVTN MWLNPEAIYV 250
KAKVRRGDRE ETWIISKEAA YKLSFQDREI EVIEEFKGER LIGKYVKNPV 300
TGDEVIILPA EFVDPDNATG VVMSVPAHAP FDHVALEDLK KETEILLKYD 350
IDPRVVEEIS YISLIKLEGY GEFPAVEEVE KLGVKSQKDE EKLEEATKNI 400
YKAEYHKGVF KIEPYAGKPV QEVKDLIAKE LQEKGIAEIM YEFAEKPVIS 450
RFGNQAVIKI IHDQWFIDYG NPEWKEKARE ALANMTIYPE SRRTQFEAVI 500
DWLDKKACAR KVGLGTPLPW DPEWVIESLS DSTIYMAYYT ISRHINKLRE 550
EGRLDPEKLD REFFDYLFRE EFSEEREKEL AEKTGIPAEI IHEMKEEFEY 600
WYPLDWRCSA KDLIPNHLTF FIFNHVAIFR KGHWPRGIAV NGFGTLEGQK 650
MSKSKGNVLN FIDAIEENGA DVVRLYIMGL AEHDSDFDWR RKEVGKLRKQ 700
VERFYELVSE FASYEAKEGV ELKDIDRWML HRLNKAIEGA TKGLEEFRTR 750
TAVQWAFYSV LNDLRWYLRR TEGRDDEAKR YVLRTLADVW VRLMAPFTPH 800
ISEELWEKLG GEGFVSLAKW PEPNPAWWNE TIELEEEYVK NLIEDIKEII 850
RVAKIEDAKR AYIYTAPEWK WRVAEAVAEK RDFKAAMSEL MKDPEMRKHG 900
KEISKMIQRL IKDRAFEIKR IDEEKALREA KDFIEKELGL EIIINPEEDK 950
GGKKKAAMPM KPAVFVE 967
Length:967
Mass (Da):113,529
Last modified:January 20, 2009 - v1
Checksum:iBC2818D12683C5ED
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000855 Genomic DNA. Translation: ACJ15626.1.
RefSeqiYP_002306523.1. NC_011529.1.

Genome annotation databases

EnsemblBacteriaiACJ15626; ACJ15626; TON_0141.
GeneIDi7017795.
KEGGiton:TON_0141.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000855 Genomic DNA. Translation: ACJ15626.1 .
RefSeqi YP_002306523.1. NC_011529.1.

3D structure databases

ProteinModelPortali B6YST9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 523850.TON_0141.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACJ15626 ; ACJ15626 ; TON_0141 .
GeneIDi 7017795.
KEGGi ton:TON_0141.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000216620.
KOi K01869.
OMAi YSKFVEW.

Enzyme and pathway databases

BioCyci TONN523850:GC7X-150-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_A. Leu_tRNA_synth_A.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view ]
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsi TIGR00395. leuS_arch. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Thermococcus onnurineus NA1 reveals a mixed heterotrophic and carboxydotrophic metabolism."
    Lee H.S., Kang S.G., Bae S.S., Lim J.K., Cho Y., Kim Y.J., Jeon J.H., Cha S.-S., Kwon K.K., Kim H.-T., Park C.-J., Lee H.-W., Kim S.I., Chun J., Colwell R.R., Kim S.-J., Lee J.-H.
    J. Bacteriol. 190:7491-7499(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NA1.

Entry informationi

Entry nameiSYL_THEON
AccessioniPrimary (citable) accession number: B6YST9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: January 20, 2009
Last modified: May 14, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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