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B6YST9

- SYL_THEON

UniProt

B6YST9 - SYL_THEON

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Thermococcus onnurineus (strain NA1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei653 – 6531ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTONN523850:GC7X-150-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:TON_0141
OrganismiThermococcus onnurineus (strain NA1)
Taxonomic identifieri523850 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
ProteomesiUP000002727: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 967967Leucine--tRNA ligasePRO_1000199235Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi523850.TON_0141.

Structurei

3D structure databases

ProteinModelPortaliB6YST9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi43 – 5311"HIGH" regionAdd
BLAST
Motifi650 – 6545"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000216620.
KOiK01869.
OMAiYSKFVEW.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_A. Leu_tRNA_synth_A.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsiTIGR00395. leuS_arch. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B6YST9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAELNFKAIE EKWQKRWMED RVFEPDRNAK PKEKKFYITV AFPYLSGHLH
60 70 80 90 100
VGHARTYTIP DVIARFKRMQ GYNVLFPMAW HITGAPIVGI AERIKNRDPK
110 120 130 140 150
TIHIYRDVYK VPEEILWKFE DPKEIVKYFM KAARETFIRA GFSVDWSREF
160 170 180 190 200
HTTSLFPPFS KFIEWQFWTL KDMGLVVKGA HRVRWDPVVG TPLGDHDIME
210 220 230 240 250
GEDVQILEYV IIKFILEENG EEIYMPAATL RPETVYGVTN MWLNPEAIYV
260 270 280 290 300
KAKVRRGDRE ETWIISKEAA YKLSFQDREI EVIEEFKGER LIGKYVKNPV
310 320 330 340 350
TGDEVIILPA EFVDPDNATG VVMSVPAHAP FDHVALEDLK KETEILLKYD
360 370 380 390 400
IDPRVVEEIS YISLIKLEGY GEFPAVEEVE KLGVKSQKDE EKLEEATKNI
410 420 430 440 450
YKAEYHKGVF KIEPYAGKPV QEVKDLIAKE LQEKGIAEIM YEFAEKPVIS
460 470 480 490 500
RFGNQAVIKI IHDQWFIDYG NPEWKEKARE ALANMTIYPE SRRTQFEAVI
510 520 530 540 550
DWLDKKACAR KVGLGTPLPW DPEWVIESLS DSTIYMAYYT ISRHINKLRE
560 570 580 590 600
EGRLDPEKLD REFFDYLFRE EFSEEREKEL AEKTGIPAEI IHEMKEEFEY
610 620 630 640 650
WYPLDWRCSA KDLIPNHLTF FIFNHVAIFR KGHWPRGIAV NGFGTLEGQK
660 670 680 690 700
MSKSKGNVLN FIDAIEENGA DVVRLYIMGL AEHDSDFDWR RKEVGKLRKQ
710 720 730 740 750
VERFYELVSE FASYEAKEGV ELKDIDRWML HRLNKAIEGA TKGLEEFRTR
760 770 780 790 800
TAVQWAFYSV LNDLRWYLRR TEGRDDEAKR YVLRTLADVW VRLMAPFTPH
810 820 830 840 850
ISEELWEKLG GEGFVSLAKW PEPNPAWWNE TIELEEEYVK NLIEDIKEII
860 870 880 890 900
RVAKIEDAKR AYIYTAPEWK WRVAEAVAEK RDFKAAMSEL MKDPEMRKHG
910 920 930 940 950
KEISKMIQRL IKDRAFEIKR IDEEKALREA KDFIEKELGL EIIINPEEDK
960
GGKKKAAMPM KPAVFVE
Length:967
Mass (Da):113,529
Last modified:January 20, 2009 - v1
Checksum:iBC2818D12683C5ED
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000855 Genomic DNA. Translation: ACJ15626.1.
RefSeqiYP_002306523.1. NC_011529.1.

Genome annotation databases

EnsemblBacteriaiACJ15626; ACJ15626; TON_0141.
GeneIDi7017795.
KEGGiton:TON_0141.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000855 Genomic DNA. Translation: ACJ15626.1 .
RefSeqi YP_002306523.1. NC_011529.1.

3D structure databases

ProteinModelPortali B6YST9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 523850.TON_0141.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACJ15626 ; ACJ15626 ; TON_0141 .
GeneIDi 7017795.
KEGGi ton:TON_0141.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000216620.
KOi K01869.
OMAi YSKFVEW.

Enzyme and pathway databases

BioCyci TONN523850:GC7X-150-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_A. Leu_tRNA_synth_A.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view ]
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsi TIGR00395. leuS_arch. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Thermococcus onnurineus NA1 reveals a mixed heterotrophic and carboxydotrophic metabolism."
    Lee H.S., Kang S.G., Bae S.S., Lim J.K., Cho Y., Kim Y.J., Jeon J.H., Cha S.-S., Kwon K.K., Kim H.-T., Park C.-J., Lee H.-W., Kim S.I., Chun J., Colwell R.R., Kim S.-J., Lee J.-H.
    J. Bacteriol. 190:7491-7499(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NA1.

Entry informationi

Entry nameiSYL_THEON
AccessioniPrimary (citable) accession number: B6YST9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: January 20, 2009
Last modified: October 29, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3