Reviewed, UniProtKB/Swiss-Prot B6YRV5 (DXS_AZOPC)

Names and origin

Protein names

Recommended name:
    1-deoxy-D-xylulose-5-phosphate synthase
    EC=2.2.1.7
Alternative name(s):
    1-deoxyxylulose-5-phosphate synthase
      Short name=DXP synthase
      Short name=DXPS

Gene names

Name:	dxs
Ordered Locus Names:	CFPG_664

Organism

Azobacteroides pseudotrichonymphae genomovar. CFP2 [Complete proteome] [HAMAP]

Taxonomic identifier

511995 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Candidatus Azobacteroides

Protein attributes

Sequence length	632 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) By similarity.
Catalytic activity	Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. HAMAP MF_00315
Cofactor	Binds 1 thiamine pyrophosphate per subunit By similarity.
Pathway	Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1. HAMAP MF_00315
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the transketolase family. DXPS subfamily.

Ontologies

Keywords
Biological process	Isoprene biosynthesis Thiamine biosynthesis
Ligand	Thiamine pyrophosphate
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	terpenoid biosynthetic process Inferred from electronic annotation. Source: HAMAP thiamin biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	1-deoxy-D-xylulose-5-phosphate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 632	632	1-deoxy-D-xylulose-5-phosphate synthase HAMAP MF_00315		PRO_1000115720

Sequences

	Sequence		Length	Mass (Da)
	B6YRV5-1 [UniParc]. Last modified January 20, 2009. Version 1. Checksum: C44006A6CE6A17D2	FASTA	632	70,381
	10 20 30 40 50 60 MKKISDYSLL FKINSPEDLR KLAIEQVEQV CKELREYIIE VLSENPGHLG SNLGTVELTV 70 80 90 100 110 120 ALHYVFNTPY DRIVWDVGHQ AYGHKILTER RESFHTLRKL GGISGFPNPQ ESEYDAFIAG 130 140 150 160 170 180 HASNSISAAL GMAIASWLKG ENRKIVAIIG DGSITGGLAF EGLNNVSSNP NDLLIVLNDN 190 200 210 220 230 240 NMAIDRSVGG LSQSLIKITT SYTYNTIRFK LYNFLKKYSI IKERERGFIL RFTNSLKALL 250 260 270 280 290 300 TKQHNIFEGL NIRYFGPIDG HNIKELVKVF EDIKSMKGPK LLHVCTVKGK GFGPAENKAD 310 320 330 340 350 360 VWHAPGKFNP ETGERIKVWS ENLPSLYQDV FGHTLVELAR MNNNIVGVTP AMSSGCSMTF 370 380 390 400 410 420 LMKEMPHRTF DVGIAEGHAI TFAAGLAKEG MIPFCNVYSS FMQRAYDNII HDAVLQNLNM 430 440 450 460 470 480 ILCLDRAGLV GEDGVTHHGV LDLAYLRCIP NITITAPLNE KDLRNLMFTA IQPNAKGVFV 490 500 510 520 530 540 IRYPKGYGEL KNWEYSFEAL PVGKGRKLKE GKEIAVVSIG TIGNLARKAI RLVEKLGISV 550 560 570 580 590 600 AHYDMIYLKP IDEELLHEIG KNYRCVVVIE DGTIKGGLGT AVIEFMVQNG YDPKIKQIGV 610 620 630 PDEFIPHGTI AELYKLCGMD IKSIVKCLIE EK

References

[1]

"Genome of an endosymbiont coupling N2 fixation to cellulolysis within RT protist cells in termite gut." Hongoh Y., Sharma V.K., Prakash T., Noda S., Toh H., Taylor T.D., Kudo T., Sakaki Y., Toyoda A., Hattori M., Ohkuma M. Science 322:1108-1109(2008) [PubMed: 19008447] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AP010656 Genomic DNA. Translation: BAG83927.1.
RefSeq	YP_002309338.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	7039404.
GenomeReviews	Gene locus CFPG_664 in contig AP010656_GR.
KEGG	aps:CFPG_664.
Organism-specific databases
CMR	Search...
Family and domain databases
HAMAP	MF_00315. [Tree]
InterPro	IPR005477. Dxylulose-5-P_synthase. IPR015941. Transketolase-like_C. IPR005475. Transketolase-like_Pyr-bd. IPR005476. Transketolase_C. IPR005474. Transketolase_N. [Graphical view]
Gene3D	G3DSA:3.40.50.920. Transketo_C_like. 1 hit.
Pfam	PF02779. Transket_pyr. 1 hit. PF02780. Transketolase_C. 1 hit. [Graphical view]
TIGRFAMs	TIGR00204. dxs. 1 hit.
PROSITE	PS00801. TRANSKETOLASE_1. False negative. PS00802. TRANSKETOLASE_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DXS_AZOPC

Accession

Primary (citable) accession number: B6YRV5

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	January 20, 2009
Last modified:	September 22, 2009
This is version 8 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)