B6YRU3 (B6YRU3_AZOPC) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
GTP cyclohydrolase 1 HAMAP MF_00223
EC=3.5.4.16 HAMAP MF_00223

Alternative name(s):
GTP cyclohydrolase I HAMAP MF_00223

Gene names

Name:	folE HAMAP MF_00223
Ordered Locus Names:	CFPG_652

Organism

Azobacteroides pseudotrichonymphae genomovar. CFP2 [Complete proteome] [HAMAP]

Taxonomic identifier

511995 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Candidatus Azobacteroides

Protein attributes

Sequence length	192 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP MF_00223 SAAS SAAS001474
Pathway	Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP MF_00223 SAAS SAAS001474
Subunit structure	Homopolymer By similarity. HAMAP MF_00223
Sequence similarities	Belongs to the GTP cyclohydrolase I family. HAMAP MF_00223

Ontologies

Keywords
Biological process	One-carbon metabolism HAMAP MF_00223
Ligand	GTP-binding HAMAP MF_00223 Metal-binding HAMAP MF_00223 SAAS SAAS001474 Nucleotide-binding Zinc HAMAP MF_00223 SAAS SAAS001474
Molecular function	Hydrolase HAMAP MF_00223 SAAS SAAS001474 EMBL BAG83915.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	one-carbon metabolic process Inferred from electronic annotation. Source: HAMAP tetrahydrofolate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTP cyclohydrolase I activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Metal binding	84	1	Zinc By similarity HAMAP MF_00223
	Metal binding	87	1	Zinc By similarity HAMAP MF_00223
	Metal binding	155	1	Zinc By similarity HAMAP MF_00223

Sequences

	Sequence		Length	Mass (Da)
	B6YRU3 [UniParc]. Last modified January 20, 2009. Version 1. Checksum: 4FEFFA0C043F047B	FASTA	192	22,162
	10 20 30 40 50 60 MKRTAEELRK EEKLAFHYTQ ILKLLGEDPK RQGLLNTPKR VVESIMYLTK GYAQSAEEIL 70 80 90 100 110 120 SSAIFVEDYR QMVIVRNIDF FSLCEHHLLP FFGKAHVAYI PNNVVSGLSK IPRVVDVYAR 130 140 150 160 170 180 RLQIQERMTT QIKSCIQEIL NPLGVMVVIE AQHMCIQMRG VEKQNSITTT SDFTGVFNQA 190 KTREEFIKLI KN

References

[1]

"Genome of an endosymbiont coupling N2 fixation to cellulolysis within RT protist cells in termite gut." Hongoh Y., Sharma V.K., Prakash T., Noda S., Toh H., Taylor T.D., Kudo T., Sakaki Y., Toyoda A., Hattori M., Ohkuma M. Science 322:1108-1109(2008) [PubMed: 19008447] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP010656 Genomic DNA. Translation: BAG83915.1.
RefSeq	YP_002309326.1. NC_011565.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	B6YRU3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7039513.
GenomeReviews	Gene locus CFPG_652 in contig AP010656_GR.
KEGG	aps:CFPG_652.
PATRIC	31963232. VBICanAzo57536_0969.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG370191.
OMA	HMVPFIG.
ProtClustDB	PRK09347.
Family and domain databases
HAMAP	MF_00223. FolE. [Tree]
InterPro	IPR001474. GTP_CycHdrlase_I. IPR020602. GTP_CycHdrlase_I/CN_OxRdtase. IPR018234. GTP_CycHdrlase_I_CS. [Graphical view]
KO	K01495.
PANTHER	PTHR11109. GTP_cyclohydro_I. 1 hit.
Pfam	PF01227. GTP_cyclohydroI. 1 hit. [Graphical view]
TIGRFAMs	TIGR00063. FolE. 1 hit.
PROSITE	PS00859. GTP_CYCLOHYDROL_1_1. 1 hit. PS00860. GTP_CYCLOHYDROL_1_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B6YRU3_AZOPC

Accession

Primary (citable) accession number: B6YRU3

Entry history

Integrated into UniProtKB/TrEMBL:	January 20, 2009
Last sequence update:	January 20, 2009
Last modified:	December 14, 2011
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)