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B6YRS4

- SYL_AZOPC

UniProt

B6YRS4 - SYL_AZOPC

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Azobacteroides pseudotrichonymphae genomovar. CFP2
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (20 Jan 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei695 – 6951ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCAZO511995:GKF1-671-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:CFPG_633
    OrganismiAzobacteroides pseudotrichonymphae genomovar. CFP2
    Taxonomic identifieri511995 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesCandidatus Azobacteroides
    ProteomesiUP000000723: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 918918Leucine--tRNA ligasePRO_1000091288Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi511995.CFPG_633.

    Structurei

    3D structure databases

    ProteinModelPortaliB6YRS4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi40 – 5112"HIGH" regionAdd
    BLAST
    Motifi692 – 6965"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiKGNPLES.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 4 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B6YRS4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKYDFDAIEK KWQKYWKENR TYQVNIDRNK PKYYVLDMFP YPSGVGLHVG    50
    HPLGYIASDI YARYKRLKGF NVLHPMGYDA YGLPAEQYAI QTGQHPSITT 100
    KENINRYRKQ LDKIGFCFDW DREIRTCDPK YYQWTQWVFI QMFNSYYCKE 150
    AQRARPITEL VKILENQGTG GLHLACTKEI HLTANEWQMK DEKSKQAILM 200
    NYRIAYLSDI VVNWCPALGT VLANDEISGG ISIRGGYTVE QRKMRQWCLR 250
    ISAYAKRLLE GLDKIEWTDS LKKMQRNWIG RSEGVELRFK IKDENIEFMI 300
    FTTRPETIFG VTFIVIAPES EWLTQTIISK KKDSVDSYLN LVKRRTERER 350
    ISNRKVTGVF TGSYAVHPIS GETIPIWISD YILADYGTGA VMAVPAHDSR 400
    DYAFAKHFDL PIIPLIEDID ISKESFDIKE GIMTNSDFLN GLSVKQAIQK 450
    VKEYIKDENL GKIKVNYRLR DAIFSRQRYW GEPFPIYYKN GIPYAVDEED 500
    LPIKLPEIDK FLPAETGKPP LGRAKNWTYK GYPLELTTMP GFAGSSAYYL 550
    RYEDPHNSEC LVSSEANEYW QNVDLYIGGI EHATGHLIYS RFWNKFLFDL 600
    GIVAKEEPFK KLINQGMIQG RSNFVYRIKN TNTFVSYGLK HQYDVTPIHV 650
    DINLVFDDVL NIESFRDWNS EYKNAEFILE NGKYVCGWAI EKMSKSMFNT 700
    VSPDNIVNRF GADAFRLYEM FLGPLEQSKP WDTKGIDGIA RFLKRLWNLF 750
    FENDVLKVSN SLPLDKELKS IHKLIKKVSW DIENFSFNTS VAAFMICINE 800
    LTLLKCSKHS ILSDLVIVLA PFAPHIAEEL WHLLGNEATI FDSQFPKCNE 850
    EYLKEENVKY TVSFNGKARF ILNFPKKISE ENVKDTVLKC ESSKKWLKNK 900
    IPKKIIIIPN KIVNIVFD 918
    Length:918
    Mass (Da):106,760
    Last modified:January 20, 2009 - v1
    Checksum:i708D3B4BAD69121D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP010656 Genomic DNA. Translation: BAG83896.1.
    RefSeqiYP_002309307.1. NC_011565.1.

    Genome annotation databases

    EnsemblBacteriaiBAG83896; BAG83896; CFPG_633.
    GeneIDi7039386.
    KEGGiaps:CFPG_633.
    PATRICi31963194. VBICanAzo57536_0950.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP010656 Genomic DNA. Translation: BAG83896.1 .
    RefSeqi YP_002309307.1. NC_011565.1.

    3D structure databases

    ProteinModelPortali B6YRS4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 511995.CFPG_633.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAG83896 ; BAG83896 ; CFPG_633 .
    GeneIDi 7039386.
    KEGGi aps:CFPG_633.
    PATRICi 31963194. VBICanAzo57536_0950.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi KGNPLES.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci CAZO511995:GKF1-671-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 4 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome of an endosymbiont coupling N2 fixation to cellulolysis within RT protist cells in termite gut."
      Hongoh Y., Sharma V.K., Prakash T., Noda S., Toh H., Taylor T.D., Kudo T., Sakaki Y., Toyoda A., Hattori M., Ohkuma M.
      Science 322:1108-1109(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiSYL_AZOPC
    AccessioniPrimary (citable) accession number: B6YRS4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: January 20, 2009
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3