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B6YRS4 (SYL_AZOPC) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:CFPG_633
OrganismAzobacteroides pseudotrichonymphae genomovar. CFP2 [Complete proteome] [HAMAP]
Taxonomic identifier511995 [NCBI]
Taxonomic lineageBacteriaBacteroidetesBacteroidiaBacteroidalesCandidatus Azobacteroides

Protein attributes

Sequence length918 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 918918Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_1000091288

Regions

Motif40 – 5112"HIGH" region HAMAP-Rule MF_00049
Motif692 – 6965"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site6951ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
B6YRS4 [UniParc].

Last modified January 20, 2009. Version 1.
Checksum: 708D3B4BAD69121D

FASTA918106,760
        10         20         30         40         50         60 
MKYDFDAIEK KWQKYWKENR TYQVNIDRNK PKYYVLDMFP YPSGVGLHVG HPLGYIASDI 

        70         80         90        100        110        120 
YARYKRLKGF NVLHPMGYDA YGLPAEQYAI QTGQHPSITT KENINRYRKQ LDKIGFCFDW 

       130        140        150        160        170        180 
DREIRTCDPK YYQWTQWVFI QMFNSYYCKE AQRARPITEL VKILENQGTG GLHLACTKEI 

       190        200        210        220        230        240 
HLTANEWQMK DEKSKQAILM NYRIAYLSDI VVNWCPALGT VLANDEISGG ISIRGGYTVE 

       250        260        270        280        290        300 
QRKMRQWCLR ISAYAKRLLE GLDKIEWTDS LKKMQRNWIG RSEGVELRFK IKDENIEFMI 

       310        320        330        340        350        360 
FTTRPETIFG VTFIVIAPES EWLTQTIISK KKDSVDSYLN LVKRRTERER ISNRKVTGVF 

       370        380        390        400        410        420 
TGSYAVHPIS GETIPIWISD YILADYGTGA VMAVPAHDSR DYAFAKHFDL PIIPLIEDID 

       430        440        450        460        470        480 
ISKESFDIKE GIMTNSDFLN GLSVKQAIQK VKEYIKDENL GKIKVNYRLR DAIFSRQRYW 

       490        500        510        520        530        540 
GEPFPIYYKN GIPYAVDEED LPIKLPEIDK FLPAETGKPP LGRAKNWTYK GYPLELTTMP 

       550        560        570        580        590        600 
GFAGSSAYYL RYEDPHNSEC LVSSEANEYW QNVDLYIGGI EHATGHLIYS RFWNKFLFDL 

       610        620        630        640        650        660 
GIVAKEEPFK KLINQGMIQG RSNFVYRIKN TNTFVSYGLK HQYDVTPIHV DINLVFDDVL 

       670        680        690        700        710        720 
NIESFRDWNS EYKNAEFILE NGKYVCGWAI EKMSKSMFNT VSPDNIVNRF GADAFRLYEM 

       730        740        750        760        770        780 
FLGPLEQSKP WDTKGIDGIA RFLKRLWNLF FENDVLKVSN SLPLDKELKS IHKLIKKVSW 

       790        800        810        820        830        840 
DIENFSFNTS VAAFMICINE LTLLKCSKHS ILSDLVIVLA PFAPHIAEEL WHLLGNEATI 

       850        860        870        880        890        900 
FDSQFPKCNE EYLKEENVKY TVSFNGKARF ILNFPKKISE ENVKDTVLKC ESSKKWLKNK 

       910 
IPKKIIIIPN KIVNIVFD 

« Hide

References

[1]"Genome of an endosymbiont coupling N2 fixation to cellulolysis within RT protist cells in termite gut."
Hongoh Y., Sharma V.K., Prakash T., Noda S., Toh H., Taylor T.D., Kudo T., Sakaki Y., Toyoda A., Hattori M., Ohkuma M.
Science 322:1108-1109(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP010656 Genomic DNA. Translation: BAG83896.1.
RefSeqYP_002309307.1. NC_011565.1.

3D structure databases

ProteinModelPortalB6YRS4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING511995.CFPG_633.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAG83896; BAG83896; CFPG_633.
GeneID7039386.
KEGGaps:CFPG_633.
PATRIC31963194. VBICanAzo57536_0950.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000200748.
KOK01869.
OMAKGNPLES.
OrthoDBEOG63Z74X.

Enzyme and pathway databases

BioCycCAZO511995:GKF1-671-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSYL_AZOPC
AccessionPrimary (citable) accession number: B6YRS4
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: January 20, 2009
Last modified: May 14, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries