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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Azobacteroides pseudotrichonymphae genomovar. CFP2
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei695 – 6951ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCAZO511995:GKF1-671-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:CFPG_633
OrganismiAzobacteroides pseudotrichonymphae genomovar. CFP2
Taxonomic identifieri511995 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesCandidatus Azobacteroides
ProteomesiUP000000723 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 918918Leucine--tRNA ligasePRO_1000091288Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi511995.CFPG_633.

Structurei

3D structure databases

ProteinModelPortaliB6YRS4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5112"HIGH" regionAdd
BLAST
Motifi692 – 6965"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiREKNDWE.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

B6YRS4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKYDFDAIEK KWQKYWKENR TYQVNIDRNK PKYYVLDMFP YPSGVGLHVG
60 70 80 90 100
HPLGYIASDI YARYKRLKGF NVLHPMGYDA YGLPAEQYAI QTGQHPSITT
110 120 130 140 150
KENINRYRKQ LDKIGFCFDW DREIRTCDPK YYQWTQWVFI QMFNSYYCKE
160 170 180 190 200
AQRARPITEL VKILENQGTG GLHLACTKEI HLTANEWQMK DEKSKQAILM
210 220 230 240 250
NYRIAYLSDI VVNWCPALGT VLANDEISGG ISIRGGYTVE QRKMRQWCLR
260 270 280 290 300
ISAYAKRLLE GLDKIEWTDS LKKMQRNWIG RSEGVELRFK IKDENIEFMI
310 320 330 340 350
FTTRPETIFG VTFIVIAPES EWLTQTIISK KKDSVDSYLN LVKRRTERER
360 370 380 390 400
ISNRKVTGVF TGSYAVHPIS GETIPIWISD YILADYGTGA VMAVPAHDSR
410 420 430 440 450
DYAFAKHFDL PIIPLIEDID ISKESFDIKE GIMTNSDFLN GLSVKQAIQK
460 470 480 490 500
VKEYIKDENL GKIKVNYRLR DAIFSRQRYW GEPFPIYYKN GIPYAVDEED
510 520 530 540 550
LPIKLPEIDK FLPAETGKPP LGRAKNWTYK GYPLELTTMP GFAGSSAYYL
560 570 580 590 600
RYEDPHNSEC LVSSEANEYW QNVDLYIGGI EHATGHLIYS RFWNKFLFDL
610 620 630 640 650
GIVAKEEPFK KLINQGMIQG RSNFVYRIKN TNTFVSYGLK HQYDVTPIHV
660 670 680 690 700
DINLVFDDVL NIESFRDWNS EYKNAEFILE NGKYVCGWAI EKMSKSMFNT
710 720 730 740 750
VSPDNIVNRF GADAFRLYEM FLGPLEQSKP WDTKGIDGIA RFLKRLWNLF
760 770 780 790 800
FENDVLKVSN SLPLDKELKS IHKLIKKVSW DIENFSFNTS VAAFMICINE
810 820 830 840 850
LTLLKCSKHS ILSDLVIVLA PFAPHIAEEL WHLLGNEATI FDSQFPKCNE
860 870 880 890 900
EYLKEENVKY TVSFNGKARF ILNFPKKISE ENVKDTVLKC ESSKKWLKNK
910
IPKKIIIIPN KIVNIVFD
Length:918
Mass (Da):106,760
Last modified:January 20, 2009 - v1
Checksum:i708D3B4BAD69121D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP010656 Genomic DNA. Translation: BAG83896.1.
RefSeqiWP_012573656.1. NC_011565.1.
YP_002309307.1. NC_011565.1.

Genome annotation databases

EnsemblBacteriaiBAG83896; BAG83896; CFPG_633.
KEGGiaps:CFPG_633.
PATRICi31963194. VBICanAzo57536_0950.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP010656 Genomic DNA. Translation: BAG83896.1.
RefSeqiWP_012573656.1. NC_011565.1.
YP_002309307.1. NC_011565.1.

3D structure databases

ProteinModelPortaliB6YRS4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi511995.CFPG_633.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAG83896; BAG83896; CFPG_633.
KEGGiaps:CFPG_633.
PATRICi31963194. VBICanAzo57536_0950.

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiREKNDWE.
OrthoDBiEOG63Z74X.

Enzyme and pathway databases

BioCyciCAZO511995:GKF1-671-MONOMER.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome of an endosymbiont coupling N2 fixation to cellulolysis within RT protist cells in termite gut."
    Hongoh Y., Sharma V.K., Prakash T., Noda S., Toh H., Taylor T.D., Kudo T., Sakaki Y., Toyoda A., Hattori M., Ohkuma M.
    Science 322:1108-1109(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiSYL_AZOPC
AccessioniPrimary (citable) accession number: B6YRS4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: January 20, 2009
Last modified: May 27, 2015
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.