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B6YRS4

- SYL_AZOPC

UniProt

B6YRS4 - SYL_AZOPC

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Azobacteroides pseudotrichonymphae genomovar. CFP2
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei695 – 6951ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCAZO511995:GKF1-671-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:CFPG_633
OrganismiAzobacteroides pseudotrichonymphae genomovar. CFP2
Taxonomic identifieri511995 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesCandidatus Azobacteroides
ProteomesiUP000000723: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 918918Leucine--tRNA ligasePRO_1000091288Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi511995.CFPG_633.

Structurei

3D structure databases

ProteinModelPortaliB6YRS4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5112"HIGH" regionAdd
BLAST
Motifi692 – 6965"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiKGNPLES.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

B6YRS4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKYDFDAIEK KWQKYWKENR TYQVNIDRNK PKYYVLDMFP YPSGVGLHVG
60 70 80 90 100
HPLGYIASDI YARYKRLKGF NVLHPMGYDA YGLPAEQYAI QTGQHPSITT
110 120 130 140 150
KENINRYRKQ LDKIGFCFDW DREIRTCDPK YYQWTQWVFI QMFNSYYCKE
160 170 180 190 200
AQRARPITEL VKILENQGTG GLHLACTKEI HLTANEWQMK DEKSKQAILM
210 220 230 240 250
NYRIAYLSDI VVNWCPALGT VLANDEISGG ISIRGGYTVE QRKMRQWCLR
260 270 280 290 300
ISAYAKRLLE GLDKIEWTDS LKKMQRNWIG RSEGVELRFK IKDENIEFMI
310 320 330 340 350
FTTRPETIFG VTFIVIAPES EWLTQTIISK KKDSVDSYLN LVKRRTERER
360 370 380 390 400
ISNRKVTGVF TGSYAVHPIS GETIPIWISD YILADYGTGA VMAVPAHDSR
410 420 430 440 450
DYAFAKHFDL PIIPLIEDID ISKESFDIKE GIMTNSDFLN GLSVKQAIQK
460 470 480 490 500
VKEYIKDENL GKIKVNYRLR DAIFSRQRYW GEPFPIYYKN GIPYAVDEED
510 520 530 540 550
LPIKLPEIDK FLPAETGKPP LGRAKNWTYK GYPLELTTMP GFAGSSAYYL
560 570 580 590 600
RYEDPHNSEC LVSSEANEYW QNVDLYIGGI EHATGHLIYS RFWNKFLFDL
610 620 630 640 650
GIVAKEEPFK KLINQGMIQG RSNFVYRIKN TNTFVSYGLK HQYDVTPIHV
660 670 680 690 700
DINLVFDDVL NIESFRDWNS EYKNAEFILE NGKYVCGWAI EKMSKSMFNT
710 720 730 740 750
VSPDNIVNRF GADAFRLYEM FLGPLEQSKP WDTKGIDGIA RFLKRLWNLF
760 770 780 790 800
FENDVLKVSN SLPLDKELKS IHKLIKKVSW DIENFSFNTS VAAFMICINE
810 820 830 840 850
LTLLKCSKHS ILSDLVIVLA PFAPHIAEEL WHLLGNEATI FDSQFPKCNE
860 870 880 890 900
EYLKEENVKY TVSFNGKARF ILNFPKKISE ENVKDTVLKC ESSKKWLKNK
910
IPKKIIIIPN KIVNIVFD
Length:918
Mass (Da):106,760
Last modified:January 20, 2009 - v1
Checksum:i708D3B4BAD69121D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP010656 Genomic DNA. Translation: BAG83896.1.
RefSeqiYP_002309307.1. NC_011565.1.

Genome annotation databases

EnsemblBacteriaiBAG83896; BAG83896; CFPG_633.
GeneIDi7039386.
KEGGiaps:CFPG_633.
PATRICi31963194. VBICanAzo57536_0950.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP010656 Genomic DNA. Translation: BAG83896.1 .
RefSeqi YP_002309307.1. NC_011565.1.

3D structure databases

ProteinModelPortali B6YRS4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 511995.CFPG_633.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAG83896 ; BAG83896 ; CFPG_633 .
GeneIDi 7039386.
KEGGi aps:CFPG_633.
PATRICi 31963194. VBICanAzo57536_0950.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi KGNPLES.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci CAZO511995:GKF1-671-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome of an endosymbiont coupling N2 fixation to cellulolysis within RT protist cells in termite gut."
    Hongoh Y., Sharma V.K., Prakash T., Noda S., Toh H., Taylor T.D., Kudo T., Sakaki Y., Toyoda A., Hattori M., Ohkuma M.
    Science 322:1108-1109(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiSYL_AZOPC
AccessioniPrimary (citable) accession number: B6YRS4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: January 20, 2009
Last modified: October 29, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3