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Protein

Phosphoenolpyruvate carboxykinase [ATP]

Gene

pckA

Organism
Azobacteroides pseudotrichonymphae genomovar. CFP2
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.UniRule annotation

Catalytic activityi

ATP + oxaloacetate = ADP + phosphoenolpyruvate + CO2.UniRule annotation

Cofactori

Mn2+UniRule annotationNote: Binds 1 Mn2+ ion per subunit.UniRule annotation

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei59SubstrateUniRule annotation1
Binding sitei198SubstrateUniRule annotation1
Metal bindingi204ManganeseUniRule annotation1
Binding sitei204ATPUniRule annotation1
Binding sitei204SubstrateUniRule annotation1
Metal bindingi223Manganese; via tele nitrogenUniRule annotation1
Binding sitei223ATPUniRule annotation1
Metal bindingi260ManganeseUniRule annotation1
Binding sitei288ATPUniRule annotation1
Binding sitei325ATPUniRule annotation1
Binding sitei325SubstrateUniRule annotation1
Binding sitei446ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi239 – 247ATPUniRule annotation9
Nucleotide bindingi440 – 441ATPUniRule annotation2

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Gluconeogenesis

Keywords - Ligandi

ATP-binding, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxykinase [ATP]UniRule annotation (EC:4.1.1.49UniRule annotation)
Short name:
PCKUniRule annotation
Short name:
PEP carboxykinaseUniRule annotation
Short name:
PEPCKUniRule annotation
Gene namesi
Name:pckAUniRule annotation
Ordered Locus Names:CFPG_593
OrganismiAzobacteroides pseudotrichonymphae genomovar. CFP2
Taxonomic identifieri511995 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesCandidatus Azobacteroides
Proteomesi
  • UP000000723 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001250521 – 530Phosphoenolpyruvate carboxykinase [ATP]Add BLAST530

Interactioni

Protein-protein interaction databases

STRINGi511995.CFPG_593.

Family & Domainsi

Sequence similaritiesi

Belongs to the phosphoenolpyruvate carboxykinase [ATP] family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DJ1. Bacteria.
COG1866. LUCA.
HOGENOMiHOG000271471.
KOiK01610.
OMAiRFIVKEP.
OrthoDBiPOG091H03CD.

Family and domain databases

Gene3Di3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPiMF_00453. PEPCK_ATP. 1 hit.
InterProiIPR001272. PEP_carboxykinase_ATP.
IPR013035. PEP_carboxykinase_C.
IPR008210. PEP_carboxykinase_N.
IPR015994. PEPCK_ATP_CS.
[Graphical view]
PfamiPF01293. PEPCK_ATP. 1 hit.
[Graphical view]
PIRSFiPIRSF006294. PEP_crbxkin. 1 hit.
SUPFAMiSSF68923. SSF68923. 1 hit.
TIGRFAMsiTIGR00224. pckA. 1 hit.
PROSITEiPS00532. PEPCK_ATP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B6YRN4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKVDLSKYG ISNNIIVVYN PSYEDLYKAE INSENKGFEK GIVTNTGAVS
60 70 80 90 100
VDTGKFTGRS PKDRYIVKDQ ITENTIWWDG NINKPISRTI WDNLKDLTIK
110 120 130 140 150
QLNTAKKLYI IDAFCGTNND TRMKVRFIVE VAWQAHFVTN MFIRPSNYEL
160 170 180 190 200
DHYGDPDFVV FNGSKTTNPK WKEQGLNSEI YILFNLTEKE QIIGGTWYGG
210 220 230 240 250
EMKKGMFSMQ NYYLPLKGIA SMHCSANVGE KGDVAVFFGL SGTGKTTLSA
260 270 280 290 300
DPKRYLIGDD EHGWDDNGIF NYEGGCYAKV IDLSQKNEPD IWNAIRRDAL
310 320 330 340 350
LENVTVKADG TLDYSKVASK TENTRVSYPI HHINKIVLPS RAGHAKKIIY
360 370 380 390 400
LSADAFGVLP PVSVLDEKSS QYHFLCGYTS KLAGTERGIT EPIPSFSPAF
410 420 430 440 450
GEAFLTLHPT QYANVLAKKM KEHNATAYLV NTGWNGTNKR ISIQDTRAII
460 470 480 490 500
DAIIDESIEK AEKIYIPILN LYVPKSLSGV SKGILDPRDT YTNRGEWEEK
510 520 530
AKSLAAKYIK NFEQYLPEGE YLISSGPQLS
Length:530
Mass (Da):59,479
Last modified:January 20, 2009 - v1
Checksum:iCAA6E5B7AC27ECCC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP010656 Genomic DNA. Translation: BAG83856.1.
RefSeqiWP_012573616.1. NC_011565.1.

Genome annotation databases

EnsemblBacteriaiBAG83856; BAG83856; CFPG_593.
KEGGiaps:CFPG_593.
PATRICi31963094. VBICanAzo57536_0900.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP010656 Genomic DNA. Translation: BAG83856.1.
RefSeqiWP_012573616.1. NC_011565.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi511995.CFPG_593.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAG83856; BAG83856; CFPG_593.
KEGGiaps:CFPG_593.
PATRICi31963094. VBICanAzo57536_0900.

Phylogenomic databases

eggNOGiENOG4105DJ1. Bacteria.
COG1866. LUCA.
HOGENOMiHOG000271471.
KOiK01610.
OMAiRFIVKEP.
OrthoDBiPOG091H03CD.

Enzyme and pathway databases

UniPathwayiUPA00138.

Family and domain databases

Gene3Di3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPiMF_00453. PEPCK_ATP. 1 hit.
InterProiIPR001272. PEP_carboxykinase_ATP.
IPR013035. PEP_carboxykinase_C.
IPR008210. PEP_carboxykinase_N.
IPR015994. PEPCK_ATP_CS.
[Graphical view]
PfamiPF01293. PEPCK_ATP. 1 hit.
[Graphical view]
PIRSFiPIRSF006294. PEP_crbxkin. 1 hit.
SUPFAMiSSF68923. SSF68923. 1 hit.
TIGRFAMsiTIGR00224. pckA. 1 hit.
PROSITEiPS00532. PEPCK_ATP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPCKA_AZOPC
AccessioniPrimary (citable) accession number: B6YRN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: January 20, 2009
Last modified: November 2, 2016
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.