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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Azobacteroides pseudotrichonymphae genomovar. CFP2
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi490 – 4901MagnesiumUniRule annotation
Metal bindingi496 – 4961MagnesiumUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciCAZO511995:GKF1-500-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:CFPG_469
OrganismiAzobacteroides pseudotrichonymphae genomovar. CFP2
Taxonomic identifieri511995 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesCandidatus Azobacteroides
ProteomesiUP000000723 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 719719Polyribonucleotide nucleotidyltransferasePRO_1000147882Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi511995.CFPG_469.

Structurei

3D structure databases

ProteinModelPortaliB6YRB0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini557 – 61963KHUniRule annotationAdd
BLAST
Domaini629 – 69971S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiRFMFHYN.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF13014. KH_3. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B6YRB0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MINSIIKTID LGDGRTITLE TGKLAKQADG AIVLRMNNTM ILATVCVAKD
60 70 80 90 100
TNPCVDFLPL QVEYKEKFSA FGRFPGGFTK REGRASDYEI LTCRLIDRTL
110 120 130 140 150
RPLFPRDYHS EVFVNIILFS SDGEDIPDAL AGLAASAALS VSTIPFNGPI
160 170 180 190 200
SEVRVARIDG KFKINPTFGE LAKADMDIMV GATADNIMMV EGEMNEVSEE
210 220 230 240 250
EMLEAIKAAH EAIKPQCKAQ IELARIVGTT IKNTYSHEVN DEELRSDIKT
260 270 280 290 300
KLYDKVYAVA KSGQCKNKRI EAFQTIIEEY KKQFKEKELS EEKIFLIKRY
310 320 330 340 350
YYEIEKEVMR RCILDENIRI DGRKTTEIRP IWSEVNPITG PHGSAIFTRG
360 370 380 390 400
ETQALATVTL GTKLNEKIID DVLINDKERF LLHYNFPPFA TGEARAQRGI
410 420 430 440 450
GRREIGHGNL AHRALKPIIP NNYPYVIRVV SDILESNGSS SMATVCAGTL
460 470 480 490 500
SLMDAGVQIK RPVSGIAMGL IFEKEGSKYA ILSDILGDED HLGDMDFKVA
510 520 530 540 550
GTKKGITATQ MDIKIDGLSY EVLERALSQA KQGREYILDK MLETIPEPRT
560 570 580 590 600
DLKPHTPKIE IIIIPKEFIG SVIGPGGKII QRLQEETGTT ITIEEIEKMG
610 620 630 640 650
RIEIFGDNKK SIDAALTRIK GIVSVPEVGE IYEGKIRSIM PYGAFIEFLP
660 670 680 690 700
GKEGLLHISE ISWKHLESIE EAGLNEGDFI KIKLVDIDSK TGKFKLSHKI
710
LLPHSEKYTA IRREQHEKI
Length:719
Mass (Da):80,337
Last modified:January 20, 2009 - v1
Checksum:i37E96CF647AF6FEB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP010656 Genomic DNA. Translation: BAG83732.1.
RefSeqiWP_012573493.1. NC_011565.1.
YP_002309143.1. NC_011565.1.

Genome annotation databases

EnsemblBacteriaiBAG83732; BAG83732; CFPG_469.
KEGGiaps:CFPG_469.
PATRICi31962726. VBICanAzo57536_0723.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP010656 Genomic DNA. Translation: BAG83732.1.
RefSeqiWP_012573493.1. NC_011565.1.
YP_002309143.1. NC_011565.1.

3D structure databases

ProteinModelPortaliB6YRB0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi511995.CFPG_469.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAG83732; BAG83732; CFPG_469.
KEGGiaps:CFPG_469.
PATRICi31962726. VBICanAzo57536_0723.

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiRFMFHYN.
OrthoDBiEOG6WT8CC.

Enzyme and pathway databases

BioCyciCAZO511995:GKF1-500-MONOMER.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF13014. KH_3. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome of an endosymbiont coupling N2 fixation to cellulolysis within RT protist cells in termite gut."
    Hongoh Y., Sharma V.K., Prakash T., Noda S., Toh H., Taylor T.D., Kudo T., Sakaki Y., Toyoda A., Hattori M., Ohkuma M.
    Science 322:1108-1109(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiPNP_AZOPC
AccessioniPrimary (citable) accession number: B6YRB0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: January 20, 2009
Last modified: May 27, 2015
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.