Reviewed, UniProtKB/Swiss-Prot B6YQY8 (ARGC_AZOPC)

Names and origin

Protein names

Recommended name:
    N-acetyl-gamma-glutamyl-phosphate reductase
      Short name=AGPR
    EC=1.2.1.38
Alternative name(s):
    N-acetyl-glutamate semialdehyde dehydrogenase
      Short name=NAGSA dehydrogenase

Gene names

Name:	argC
Ordered Locus Names:	CFPG_347

Organism

Azobacteroides pseudotrichonymphae genomovar. CFP2 [Complete proteome] [HAMAP]

Taxonomic identifier

511995 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Candidatus Azobacteroides

Protein attributes

Sequence length	318 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_00150
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_00150
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: HAMAP NAD or NADH binding Inferred from electronic annotation. Source: InterPro protein dimerization activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 318	318	N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_00150		PRO_1000096713
Sites
	Active site	132	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	B6YQY8-1 [UniParc]. Last modified January 20, 2009. Version 1. Checksum: 1F8823AB9BCCFEFC	FASTA	318	35,474
	10 20 30 40 50 60 MVKVGIIGGG GYTAGELIRL LINHPNVNII FVHSYSNARN KIIDIHTGLI GEMDLIFSDS 70 80 90 100 110 120 YDLNEIDVLF LCSAHGDSKK FIETHTIHTE LKIIDLSIDF RHKENAGGFV YGLPELNKEI 130 140 150 160 170 180 IRKAQYIANP GCFATAVQLA LLPLAKKNLL RSEIHINAIT GSTGAGVRPT ASSHFSWRNN 190 200 210 220 230 240 NISVYKAFTH QHLKEITESL NYEPSRFNFI PVRGNFSRGI FATVYTESNL DIKDAVQIYS 250 260 270 280 290 300 NYYEDSAFTF ISDKNPDLKQ VINTNKCILH LEKHGNKLFI ISIIDNLLKG ASGQAVQNFN 310 LICGLNEKTG LFLKANAF

References

[1]

"Genome of an endosymbiont coupling N2 fixation to cellulolysis within RT protist cells in termite gut." Hongoh Y., Sharma V.K., Prakash T., Noda S., Toh H., Taylor T.D., Kudo T., Sakaki Y., Toyoda A., Hattori M., Ohkuma M. Science 322:1108-1109(2008) [PubMed: 19008447] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AP010656 Genomic DNA. Translation: BAG83610.1.
RefSeq	YP_002309021.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	7040033.
GenomeReviews	Gene locus CFPG_347 in contig AP010656_GR.
KEGG	aps:CFPG_347.
Organism-specific databases
CMR	Search...
Family and domain databases
HAMAP	MF_00150. [Tree]
InterPro	IPR000706. AGPR_act_site. IPR000534. Semialdehyde_DH_NAD-bd. IPR012280. Semialdhyde_DH_C. [Graphical view]
Pfam	PF01118. Semialdhyde_dh. 1 hit. PF02774. Semialdhyde_dhC. 1 hit. [Graphical view]
TIGRFAMs	TIGR01850. argC. 1 hit.
PROSITE	PS01224. ARGC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC_AZOPC

Accession

Primary (citable) accession number: B6YQY8

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	January 20, 2009
Last modified:	October 13, 2009
This is version 9 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)