B6YQN8 (B6YQN8_AZOPC) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Lipoprotein signal peptidase HAMAP MF_00161
EC=3.4.23.36 HAMAP MF_00161

Alternative name(s):
Prolipoprotein signal peptidase HAMAP MF_00161
Signal peptidase II HAMAP MF_00161

Gene names

Name:	lspA HAMAP MF_00161
Ordered Locus Names:	CFPG_247

Organism

Azobacteroides pseudotrichonymphae genomovar. CFP2 [Complete proteome] [HAMAP]

Taxonomic identifier

511995 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Candidatus Azobacteroides

Protein attributes

Sequence length	205 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This protein specifically catalyzes the removal of signal peptides from prolipoproteins By similarity. HAMAP MF_00161 SAAS SAAS001872
Catalytic activity	Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains. HAMAP MF_00161 SAAS SAAS001872
Pathway	Protein modification; lipoprotein biosynthesis (signal peptide cleavage). HAMAP MF_00161 SAAS SAAS001872
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_00161.
Sequence similarities	Belongs to the peptidase A8 family. HAMAP MF_00161 RuleBase RU004181

Ontologies

Keywords
Cellular component	Cell inner membrane HAMAP MF_00161 Cell membrane Membrane
Domain	Transmembrane Transmembrane helix HAMAP MF_00161 SAAS SAAS001872
Molecular function	Aspartyl protease HAMAP MF_00161 SAAS SAAS001872 Hydrolase Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	aspartic-type endopeptidase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Transmembrane	7 – 27	21	Helical; By similarity HAMAP MF_00161
	Transmembrane	64 – 84	21	Helical; By similarity HAMAP MF_00161
	Transmembrane	88 – 108	21	Helical; By similarity HAMAP MF_00161
	Transmembrane	172 – 192	21	Helical; By similarity HAMAP MF_00161
Sites
	Active site	109	1	By similarity HAMAP MF_00161
	Active site	178	1	By similarity HAMAP MF_00161

Sequences

	Sequence		Length	Mass (Da)
	B6YQN8 [UniParc]. Last modified January 20, 2009. Version 1. Checksum: 81B1BE030EE57F73	FASTA	205	23,677
	10 20 30 40 50 60 MKMSKGFWAI VLITFILLED QAIKIWIKTH VPLYKDIYIT HWFHICFIEN NGMAMGIEIT 70 80 90 100 110 120 AKLFLSIFRI IVSTGIACYL YGLVKRNFEL GYILCISMIF AGAIGNIIDS IFYGVIFSNS 130 140 150 160 170 180 TSQIVSTLFP FKGYATWLHG KVVDMFYMPF FKFSLPTWIP FVGGDEFIFF RYIFNLADVS 190 200 VCTGIAILLC FYRNTFYTSF EKNLS

References

[1]

"Genome of an endosymbiont coupling N2 fixation to cellulolysis within RT protist cells in termite gut." Hongoh Y., Sharma V.K., Prakash T., Noda S., Toh H., Taylor T.D., Kudo T., Sakaki Y., Toyoda A., Hattori M., Ohkuma M. Science 322:1108-1109(2008) [PubMed: 19008447] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP010656 Genomic DNA. Translation: BAG83510.1.
RefSeq	YP_002308921.1. NC_011565.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	B6YQN8.
Protein family/group databases
MEROPS	A08.001.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7039562.
GenomeReviews	Gene locus CFPG_247 in contig AP010656_GR.
KEGG	aps:CFPG_247.
PATRIC	31962147. VBICanAzo57536_0451.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG724422.
OMA	HGKVVDM.
Family and domain databases
HAMAP	MF_00161. LspA. [Tree]
InterPro	IPR001872. Peptidase_A8. [Graphical view]
KO	K03101.
Pfam	PF01252. Peptidase_A8. 1 hit. [Graphical view]
PRINTS	PR00781. LIPOSIGPTASE.
ProtoNet	Search...

Entry information

Entry name

B6YQN8_AZOPC

Accession

Primary (citable) accession number: B6YQN8

Entry history

Integrated into UniProtKB/TrEMBL:	January 20, 2009
Last sequence update:	January 20, 2009
Last modified:	December 14, 2011
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)