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B6YQA7

- DDL_AZOPC

UniProt

B6YQA7 - DDL_AZOPC

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Protein

D-alanine--D-alanine ligase

Gene

ddl

Organism
Azobacteroides pseudotrichonymphae genomovar. CFP2
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cell wall formation.UniRule annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotation

Cofactori

Binds 2 magnesium or manganese ions per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi276 – 2761Magnesium or manganese 1UniRule annotation
Metal bindingi289 – 2891Magnesium or manganese 1UniRule annotation
Metal bindingi289 – 2891Magnesium or manganese 2UniRule annotation
Metal bindingi291 – 2911Magnesium or manganese 2UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi149 – 20456ATPUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. D-alanine-D-alanine ligase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. manganese ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
  3. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCAZO511995:GKF1-123-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseUniRule annotation (EC:6.3.2.4UniRule annotation)
Alternative name(s):
D-Ala-D-Ala ligaseUniRule annotation
D-alanylalanine synthetaseUniRule annotation
Gene namesi
Name:ddlUniRule annotation
Ordered Locus Names:CFPG_116
OrganismiAzobacteroides pseudotrichonymphae genomovar. CFP2
Taxonomic identifieri511995 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesCandidatus Azobacteroides
ProteomesiUP000000723: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 324324D-alanine--D-alanine ligasePRO_1000116633Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi511995.CFPG_116.

Structurei

3D structure databases

ProteinModelPortaliB6YQA7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini120 – 322203ATP-graspUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the D-alanine--D-alanine ligase family.UniRule annotation
Contains 1 ATP-grasp domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1181.
HOGENOMiHOG000011592.
KOiK01921.
OMAiRSAYGIY.
OrthoDBiEOG6ND0KB.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPiMF_00047. Dala_Dala_lig.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERiPTHR23132. PTHR23132. 1 hit.
PfamiPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMiSSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B6YQA7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKNVAIVSGG YSSECVISLK SAEEVYLSID KTRYNPYIVL ITRNGWTVQG
60 70 80 90 100
GNKTEFPINK NDFSFIYKGK QIRFDFAYII IHGTPGEDGL LQGYLDILNI
110 120 130 140 150
PYSCCGVLSA SITFNKYFCN NYLRGFGVET AKSILLKQRE QIISPERIID
160 170 180 190 200
KLGLPLIVKP NDGGSSFGVT KVTNITQIQL AIRNAFNEGE GVLIESFIPG
210 220 230 240 250
TEITCGYYKT KNKQVTLPIT EIISKNDFFD FEAKYNPGMV EEITPARISK
260 270 280 290 300
KLTDEIQTLT AHIYDWVGAK GIIRIDYIIS PKKEIKMLEV NTIPGMTATS
310 320
FIPQQIRAAG LNLKEILTEI IESI
Length:324
Mass (Da):36,225
Last modified:January 20, 2009 - v1
Checksum:i598DC2A00DC20154
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP010656 Genomic DNA. Translation: BAG83379.1.
RefSeqiYP_002308790.1. NC_011565.1.

Genome annotation databases

EnsemblBacteriaiBAG83379; BAG83379; CFPG_116.
GeneIDi7039288.
KEGGiaps:CFPG_116.
PATRICi31961751. VBICanAzo57536_0260.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP010656 Genomic DNA. Translation: BAG83379.1 .
RefSeqi YP_002308790.1. NC_011565.1.

3D structure databases

ProteinModelPortali B6YQA7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 511995.CFPG_116.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAG83379 ; BAG83379 ; CFPG_116 .
GeneIDi 7039288.
KEGGi aps:CFPG_116.
PATRICi 31961751. VBICanAzo57536_0260.

Phylogenomic databases

eggNOGi COG1181.
HOGENOMi HOG000011592.
KOi K01921.
OMAi RSAYGIY.
OrthoDBi EOG6ND0KB.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci CAZO511995:GKF1-123-MONOMER.

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPi MF_00047. Dala_Dala_lig.
InterProi IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view ]
PANTHERi PTHR23132. PTHR23132. 1 hit.
Pfami PF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view ]
SUPFAMi SSF52440. SSF52440. 1 hit.
TIGRFAMsi TIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome of an endosymbiont coupling N2 fixation to cellulolysis within RT protist cells in termite gut."
    Hongoh Y., Sharma V.K., Prakash T., Noda S., Toh H., Taylor T.D., Kudo T., Sakaki Y., Toyoda A., Hattori M., Ohkuma M.
    Science 322:1108-1109(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiDDL_AZOPC
AccessioniPrimary (citable) accession number: B6YQA7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: January 20, 2009
Last modified: October 29, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3