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Reviewed, UniProtKB/Swiss-Prot B6YQA7 (DDL_AZOPC)

Last modified February 9, 2010. Version 11. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    D-alanine--D-alanine ligase
    EC=6.3.2.4
Alternative name(s):
    D-alanylalanine synthetase
    D-Ala-D-Ala ligase
Gene names
Name: ddl
Ordered Locus Names: CFPG_116
OrganismAzobacteroides pseudotrichonymphae genomovar. CFP2 [Complete proteome] [HAMAP]
Taxonomic identifier511995 [NCBI]
Taxonomic lineageBacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Candidatus Azobacteroides

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Protein attributes

Sequence length324 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP MF_00047

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP MF_00047

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP MF_00047

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00047

Subcellular location

Cytoplasm By similarity HAMAP MF_00047.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family.

Contains 1 ATP-grasp domain.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 324324D-alanine--D-alanine ligase HAMAP MF_00047
PRO_1000116633

Regions

Domain120 – 322203ATP-grasp
Nucleotide binding149 – 20456ATP By similarity

Sites

Metal binding2761Magnesium or manganese 1 By similarity
Metal binding2891Magnesium or manganese 1 By similarity
Metal binding2891Magnesium or manganese 2 By similarity
Metal binding2911Magnesium or manganese 2 By similarity

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Sequences

Sequence LengthMass (Da)Tools
B6YQA7-1 [UniParc].

Last modified January 20, 2009. Version 1.
Checksum: 598DC2A00DC20154

FASTA32436,225
        10         20         30         40         50         60 
MKNVAIVSGG YSSECVISLK SAEEVYLSID KTRYNPYIVL ITRNGWTVQG GNKTEFPINK 

        70         80         90        100        110        120 
NDFSFIYKGK QIRFDFAYII IHGTPGEDGL LQGYLDILNI PYSCCGVLSA SITFNKYFCN 

       130        140        150        160        170        180 
NYLRGFGVET AKSILLKQRE QIISPERIID KLGLPLIVKP NDGGSSFGVT KVTNITQIQL 

       190        200        210        220        230        240 
AIRNAFNEGE GVLIESFIPG TEITCGYYKT KNKQVTLPIT EIISKNDFFD FEAKYNPGMV 

       250        260        270        280        290        300 
EEITPARISK KLTDEIQTLT AHIYDWVGAK GIIRIDYIIS PKKEIKMLEV NTIPGMTATS 

       310        320 
FIPQQIRAAG LNLKEILTEI IESI

« Hide

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References

[1]"Genome of an endosymbiont coupling N2 fixation to cellulolysis within RT protist cells in termite gut."
Hongoh Y., Sharma V.K., Prakash T., Noda S., Toh H., Taylor T.D., Kudo T., Sakaki Y., Toyoda A., Hattori M., Ohkuma M.
Science 322:1108-1109(2008) [PubMed: 19008447] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP010656 Genomic DNA. Translation: BAG83379.1.
RefSeqYP_002308790.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID7039288.
GenomeReviewsGene locus CFPG_116 in contig AP010656_GR.
KEGGaps:CFPG_116.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG427092.
OMAGNEMIAH.

Family and domain databases

HAMAPMF_00047. Dala_Dala_lig.
[Tree]
InterProIPR011761. ATP-grasp.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR013817. Pre-ATP_grasp.
IPR016185. PreATP-grasp-like.
[Graphical view]
Gene3DG3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit.
G3DSA:3.40.50.20. Pre-ATP_grasp. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. False negative.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameDDL_AZOPC
AccessionPrimary (citable) accession number: B6YQA7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: January 20, 2009
Last modified: February 9, 2010
This is version 11 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents