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B6YQA7 (DDL_AZOPC) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase

EC=6.3.2.4
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene names
Name:ddl
Ordered Locus Names:CFPG_116
OrganismAzobacteroides pseudotrichonymphae genomovar. CFP2 [Complete proteome] [HAMAP]
Taxonomic identifier511995 [NCBI]
Taxonomic lineageBacteriaBacteroidetesBacteroidiaBacteroidalesCandidatus Azobacteroides

Protein attributes

Sequence length324 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 324324D-alanine--D-alanine ligase HAMAP-Rule MF_00047
PRO_1000116633

Regions

Domain120 – 322203ATP-grasp
Nucleotide binding149 – 20456ATP By similarity

Sites

Metal binding2761Magnesium or manganese 1 By similarity
Metal binding2891Magnesium or manganese 1 By similarity
Metal binding2891Magnesium or manganese 2 By similarity
Metal binding2911Magnesium or manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
B6YQA7 [UniParc].

Last modified January 20, 2009. Version 1.
Checksum: 598DC2A00DC20154

FASTA32436,225
        10         20         30         40         50         60 
MKNVAIVSGG YSSECVISLK SAEEVYLSID KTRYNPYIVL ITRNGWTVQG GNKTEFPINK 

        70         80         90        100        110        120 
NDFSFIYKGK QIRFDFAYII IHGTPGEDGL LQGYLDILNI PYSCCGVLSA SITFNKYFCN 

       130        140        150        160        170        180 
NYLRGFGVET AKSILLKQRE QIISPERIID KLGLPLIVKP NDGGSSFGVT KVTNITQIQL 

       190        200        210        220        230        240 
AIRNAFNEGE GVLIESFIPG TEITCGYYKT KNKQVTLPIT EIISKNDFFD FEAKYNPGMV 

       250        260        270        280        290        300 
EEITPARISK KLTDEIQTLT AHIYDWVGAK GIIRIDYIIS PKKEIKMLEV NTIPGMTATS 

       310        320 
FIPQQIRAAG LNLKEILTEI IESI 

« Hide

References

[1]"Genome of an endosymbiont coupling N2 fixation to cellulolysis within RT protist cells in termite gut."
Hongoh Y., Sharma V.K., Prakash T., Noda S., Toh H., Taylor T.D., Kudo T., Sakaki Y., Toyoda A., Hattori M., Ohkuma M.
Science 322:1108-1109(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP010656 Genomic DNA. Translation: BAG83379.1.
RefSeqYP_002308790.1. NC_011565.1.

3D structure databases

ProteinModelPortalB6YQA7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING511995.CFPG_116.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAG83379; BAG83379; CFPG_116.
GeneID7039288.
KEGGaps:CFPG_116.
PATRIC31961751. VBICanAzo57536_0260.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1181.
HOGENOMHOG000011592.
KOK01921.
OMARSAYGIY.
OrthoDBEOG6ND0KB.

Enzyme and pathway databases

BioCycCAZO511995:GKF1-123-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDDL_AZOPC
AccessionPrimary (citable) accession number: B6YQA7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: January 20, 2009
Last modified: May 14, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways