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Protein
Submitted name:

Prohormone convertase 2

Gene

pcsk2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine proteaseUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiREACT_327948. Insulin processing.

Protein family/group databases

MEROPSiS08.073.

Names & Taxonomyi

Protein namesi
Submitted name:
Prohormone convertase 2Imported
Gene namesi
Name:pcsk2Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-090608-1. pcsk2.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000108211.

Structurei

3D structure databases

ProteinModelPortaliB6VCA2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S8 family.UniRule annotation
Contains peptidase S8 domain.SAAS annotation
Contains peptidase Sdomain.SAAS annotation

Phylogenomic databases

eggNOGiCOG4935.
HOGENOMiHOG000192536.
HOVERGENiHBG008705.
PhylomeDBiB6VCA2.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
3.40.50.200. 1 hit.
InterProiIPR008979. Galactose-bd-like.
IPR000209. Peptidase_S8/S53_dom.
IPR023827. Peptidase_S8_Asp-AS.
IPR022398. Peptidase_S8_His-AS.
IPR023828. Peptidase_S8_Ser-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR009020. Prot_inh_propept.
IPR002884. PrprotnconvertsP.
[Graphical view]
PANTHERiPTHR10795. PTHR10795. 1 hit.
PfamiPF01483. P_proprotein. 1 hit.
PF00082. Peptidase_S8. 1 hit.
[Graphical view]
PRINTSiPR00723. SUBTILISIN.
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF52743. SSF52743. 1 hit.
SSF54897. SSF54897. 1 hit.
PROSITEiPS00136. SUBTILASE_ASP. 1 hit.
PS00137. SUBTILASE_HIS. 1 hit.
PS00138. SUBTILASE_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B6VCA2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRFRGHHRT APALFLTLIG ALMMSAAAED ELFITGHFLV QMREAAPEDA
60 70 80 90 100
QKLALEHGFE SARKLPFGED LFHFYPLEMP KTRRKRSLHQ QHHRLASDHR
110 120 130 140 150
VKNVFPQEGF GRQKRGYRDL PNTDVNMSDP LFTKQWYLIN TGQADGTPGL
160 170 180 190 200
DLNVAEAWSL GFTGKGVTIA IMDDGIDYLH PDLASNYNAE ASFDFSSNDP
210 220 230 240 250
YPYPRYTDDW FNSHGTRCAG EVSAVSNNNI CGVGVAYNSK VAGIRMLDQP
260 270 280 290 300
FMTDIIEASS ISHMPQVIDI YSASWGPTDD GKTVDGPREL TLQAMADGVN
310 320 330 340 350
KGRGGKGSIY VWASGDGGSY DDCNCDGYAS SMWTISINSA INDGRTALYD
360 370 380 390 400
ESCSSTLAST FSNGRKRNPE AGVATTDLYG NCTLRHSGTS AAAPEAAGVF
410 420 430 440 450
ALALEANPNL TWRDLQHLTV LTSKRNKLHD EVHQWRRNGV GLEFNHLFGY
460 470 480 490 500
GVLDAGGMVK LARDWKTVPE RFHCVAGSMQ DIHKIQSGNK LLLSISTDAC
510 520 530 540 550
QGKDNFVRYL EHVQAVITVN ASRRGDLNIN MTSPMGTKSI LLSRRPRDDD
560 570 580 590 600
AKVGFDKWPF MTTHTWGEDP RGPWLLEVGF QSQSDMQSGL LKEWTLMLHG
610 620 630 640
TQSAPYIDQV VRDYQSKLAM SKKEELEEEL DEAVERSLKS LLSKNN
Length:646
Mass (Da):71,779
Last modified:December 16, 2008 - v1
Checksum:iCF37C4FAA24E3523
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ373315 mRNA. Translation: ACJ05353.1.
RefSeqiNP_001135738.1. NM_001142266.1.
UniGeneiDr.24063.

Genome annotation databases

GeneIDi100004460.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ373315 mRNA. Translation: ACJ05353.1.
RefSeqiNP_001135738.1. NM_001142266.1.
UniGeneiDr.24063.

3D structure databases

ProteinModelPortaliB6VCA2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000108211.

Protein family/group databases

MEROPSiS08.073.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100004460.

Organism-specific databases

CTDi5126.
ZFINiZDB-GENE-090608-1. pcsk2.

Phylogenomic databases

eggNOGiCOG4935.
HOGENOMiHOG000192536.
HOVERGENiHBG008705.
PhylomeDBiB6VCA2.

Enzyme and pathway databases

ReactomeiREACT_327948. Insulin processing.

Miscellaneous databases

NextBioi20786255.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
3.40.50.200. 1 hit.
InterProiIPR008979. Galactose-bd-like.
IPR000209. Peptidase_S8/S53_dom.
IPR023827. Peptidase_S8_Asp-AS.
IPR022398. Peptidase_S8_His-AS.
IPR023828. Peptidase_S8_Ser-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR009020. Prot_inh_propept.
IPR002884. PrprotnconvertsP.
[Graphical view]
PANTHERiPTHR10795. PTHR10795. 1 hit.
PfamiPF01483. P_proprotein. 1 hit.
PF00082. Peptidase_S8. 1 hit.
[Graphical view]
PRINTSiPR00723. SUBTILISIN.
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF52743. SSF52743. 1 hit.
SSF54897. SSF54897. 1 hit.
PROSITEiPS00136. SUBTILASE_ASP. 1 hit.
PS00137. SUBTILASE_HIS. 1 hit.
PS00138. SUBTILASE_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning, ontogeny and tissue distribution of zebrafish (Danio rerio) prohormone convertases: pcsk1 and pcsk2."
    Morash M.G., MacDonald A.B., Croll R.P., Anini Y.
    Gen. Comp. Endocrinol. 162:179-187(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiB6VCA2_DANRE
AccessioniPrimary (citable) accession number: B6VCA2
Entry historyi
Integrated into UniProtKB/TrEMBL: December 16, 2008
Last sequence update: December 16, 2008
Last modified: June 24, 2015
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.