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Protein
Submitted name:

Prohormone convertase 2

Gene

pcsk2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Serine proteaseUniRule annotation

Protein family/group databases

MEROPSiS08.073

Names & Taxonomyi

Protein namesi
Submitted name:
Prohormone convertase 2Imported
Gene namesi
Name:pcsk2Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-090608-1 pcsk2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_500285117229 – 646Sequence analysisAdd BLAST618

Structurei

3D structure databases

ProteinModelPortaliB6VCA2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini467 – 604P/Homo BInterPro annotationAdd BLAST138

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili616 – 636Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the peptidase S8 family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, SignalSequence analysis

Phylogenomic databases

eggNOGiKOG3525 Eukaryota
KOG3526 Eukaryota
COG1404 LUCA
COG4935 LUCA
HOGENOMiHOG000192536
HOVERGENiHBG008705
KOiK01360
PhylomeDBiB6VCA2

Family and domain databases

CDDicd04059 Peptidases_S8_Protein_converta, 1 hit
Gene3Di2.60.120.260, 1 hit
3.30.70.850, 1 hit
3.40.50.200, 1 hit
InterProiView protein in InterPro
IPR008979 Galactose-bd-like_sf
IPR034182 Kexin/furin
IPR002884 P_dom
IPR000209 Peptidase_S8/S53_dom
IPR036852 Peptidase_S8/S53_dom_sf
IPR023827 Peptidase_S8_Asp-AS
IPR022398 Peptidase_S8_His-AS
IPR023828 Peptidase_S8_Ser-AS
IPR015500 Peptidase_S8_subtilisin-rel
IPR032815 S8_pro-domain
IPR038466 S8_pro-domain_sf
PfamiView protein in Pfam
PF01483 P_proprotein, 1 hit
PF00082 Peptidase_S8, 1 hit
PF16470 S8_pro-domain, 1 hit
PRINTSiPR00723 SUBTILISIN
SUPFAMiSSF49785 SSF49785, 1 hit
SSF52743 SSF52743, 1 hit
PROSITEiView protein in PROSITE
PS51829 P_HOMO_B, 1 hit
PS00136 SUBTILASE_ASP, 1 hit
PS00137 SUBTILASE_HIS, 1 hit
PS00138 SUBTILASE_SER, 1 hit

Sequencei

Sequence statusi: Complete.

B6VCA2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRFRGHHRT APALFLTLIG ALMMSAAAED ELFITGHFLV QMREAAPEDA
60 70 80 90 100
QKLALEHGFE SARKLPFGED LFHFYPLEMP KTRRKRSLHQ QHHRLASDHR
110 120 130 140 150
VKNVFPQEGF GRQKRGYRDL PNTDVNMSDP LFTKQWYLIN TGQADGTPGL
160 170 180 190 200
DLNVAEAWSL GFTGKGVTIA IMDDGIDYLH PDLASNYNAE ASFDFSSNDP
210 220 230 240 250
YPYPRYTDDW FNSHGTRCAG EVSAVSNNNI CGVGVAYNSK VAGIRMLDQP
260 270 280 290 300
FMTDIIEASS ISHMPQVIDI YSASWGPTDD GKTVDGPREL TLQAMADGVN
310 320 330 340 350
KGRGGKGSIY VWASGDGGSY DDCNCDGYAS SMWTISINSA INDGRTALYD
360 370 380 390 400
ESCSSTLAST FSNGRKRNPE AGVATTDLYG NCTLRHSGTS AAAPEAAGVF
410 420 430 440 450
ALALEANPNL TWRDLQHLTV LTSKRNKLHD EVHQWRRNGV GLEFNHLFGY
460 470 480 490 500
GVLDAGGMVK LARDWKTVPE RFHCVAGSMQ DIHKIQSGNK LLLSISTDAC
510 520 530 540 550
QGKDNFVRYL EHVQAVITVN ASRRGDLNIN MTSPMGTKSI LLSRRPRDDD
560 570 580 590 600
AKVGFDKWPF MTTHTWGEDP RGPWLLEVGF QSQSDMQSGL LKEWTLMLHG
610 620 630 640
TQSAPYIDQV VRDYQSKLAM SKKEELEEEL DEAVERSLKS LLSKNN
Length:646
Mass (Da):71,779
Last modified:December 16, 2008 - v1
Checksum:iCF37C4FAA24E3523
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ373315 mRNA Translation: ACJ05353.1
RefSeqiNP_001135738.1, NM_001142266.1
UniGeneiDr.24063

Genome annotation databases

GeneIDi100004460
KEGGidre:100004460

Similar proteinsi

Entry informationi

Entry nameiB6VCA2_DANRE
AccessioniPrimary (citable) accession number: B6VCA2
Entry historyiIntegrated into UniProtKB/TrEMBL: December 16, 2008
Last sequence update: December 16, 2008
Last modified: March 28, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health