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B6VCA2

- B6VCA2_DANRE

UniProt

B6VCA2 - B6VCA2_DANRE

Protein
Submitted name:

Prohormone convertase 2

Gene

pcsk2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (16 Dec 2008)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. serine-type endopeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine proteaseUniRule annotationSAAS annotation

    Protein family/group databases

    MEROPSiS08.073.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Prohormone convertase 2Imported
    Gene namesi
    Name:pcsk2Imported
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

    Organism-specific databases

    ZFINiZDB-GENE-090608-1. pcsk2.

    Interactioni

    Protein-protein interaction databases

    STRINGi7955.ENSDARP00000037615.

    Structurei

    3D structure databases

    ProteinModelPortaliB6VCA2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S8 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG4935.
    HOGENOMiHOG000192536.
    HOVERGENiHBG008705.
    KOiK01360.
    PhylomeDBiB6VCA2.

    Family and domain databases

    Gene3Di2.60.120.260. 1 hit.
    3.40.50.200. 1 hit.
    InterProiIPR008979. Galactose-bd-like.
    IPR000209. Peptidase_S8/S53_dom.
    IPR023827. Peptidase_S8_Asp-AS.
    IPR022398. Peptidase_S8_His-AS.
    IPR023828. Peptidase_S8_Ser-AS.
    IPR015500. Peptidase_S8_subtilisin-rel.
    IPR009020. Prot_inh_propept.
    IPR002884. PrprotnconvertsP.
    [Graphical view]
    PANTHERiPTHR10795. PTHR10795. 1 hit.
    PfamiPF01483. P_proprotein. 1 hit.
    PF00082. Peptidase_S8. 1 hit.
    [Graphical view]
    PRINTSiPR00723. SUBTILISIN.
    SUPFAMiSSF49785. SSF49785. 1 hit.
    SSF52743. SSF52743. 1 hit.
    SSF54897. SSF54897. 1 hit.
    PROSITEiPS00136. SUBTILASE_ASP. 1 hit.
    PS00137. SUBTILASE_HIS. 1 hit.
    PS00138. SUBTILASE_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B6VCA2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRRFRGHHRT APALFLTLIG ALMMSAAAED ELFITGHFLV QMREAAPEDA    50
    QKLALEHGFE SARKLPFGED LFHFYPLEMP KTRRKRSLHQ QHHRLASDHR 100
    VKNVFPQEGF GRQKRGYRDL PNTDVNMSDP LFTKQWYLIN TGQADGTPGL 150
    DLNVAEAWSL GFTGKGVTIA IMDDGIDYLH PDLASNYNAE ASFDFSSNDP 200
    YPYPRYTDDW FNSHGTRCAG EVSAVSNNNI CGVGVAYNSK VAGIRMLDQP 250
    FMTDIIEASS ISHMPQVIDI YSASWGPTDD GKTVDGPREL TLQAMADGVN 300
    KGRGGKGSIY VWASGDGGSY DDCNCDGYAS SMWTISINSA INDGRTALYD 350
    ESCSSTLAST FSNGRKRNPE AGVATTDLYG NCTLRHSGTS AAAPEAAGVF 400
    ALALEANPNL TWRDLQHLTV LTSKRNKLHD EVHQWRRNGV GLEFNHLFGY 450
    GVLDAGGMVK LARDWKTVPE RFHCVAGSMQ DIHKIQSGNK LLLSISTDAC 500
    QGKDNFVRYL EHVQAVITVN ASRRGDLNIN MTSPMGTKSI LLSRRPRDDD 550
    AKVGFDKWPF MTTHTWGEDP RGPWLLEVGF QSQSDMQSGL LKEWTLMLHG 600
    TQSAPYIDQV VRDYQSKLAM SKKEELEEEL DEAVERSLKS LLSKNN 646
    Length:646
    Mass (Da):71,779
    Last modified:December 16, 2008 - v1
    Checksum:iCF37C4FAA24E3523
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FJ373315 mRNA. Translation: ACJ05353.1.
    RefSeqiNP_001135738.1. NM_001142266.1.
    UniGeneiDr.24063.

    Genome annotation databases

    GeneIDi100004460.
    KEGGidre:100004460.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FJ373315 mRNA. Translation: ACJ05353.1 .
    RefSeqi NP_001135738.1. NM_001142266.1.
    UniGenei Dr.24063.

    3D structure databases

    ProteinModelPortali B6VCA2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7955.ENSDARP00000037615.

    Protein family/group databases

    MEROPSi S08.073.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100004460.
    KEGGi dre:100004460.

    Organism-specific databases

    CTDi 5126.
    ZFINi ZDB-GENE-090608-1. pcsk2.

    Phylogenomic databases

    eggNOGi COG4935.
    HOGENOMi HOG000192536.
    HOVERGENi HBG008705.
    KOi K01360.
    PhylomeDBi B6VCA2.

    Miscellaneous databases

    NextBioi 20786255.

    Family and domain databases

    Gene3Di 2.60.120.260. 1 hit.
    3.40.50.200. 1 hit.
    InterProi IPR008979. Galactose-bd-like.
    IPR000209. Peptidase_S8/S53_dom.
    IPR023827. Peptidase_S8_Asp-AS.
    IPR022398. Peptidase_S8_His-AS.
    IPR023828. Peptidase_S8_Ser-AS.
    IPR015500. Peptidase_S8_subtilisin-rel.
    IPR009020. Prot_inh_propept.
    IPR002884. PrprotnconvertsP.
    [Graphical view ]
    PANTHERi PTHR10795. PTHR10795. 1 hit.
    Pfami PF01483. P_proprotein. 1 hit.
    PF00082. Peptidase_S8. 1 hit.
    [Graphical view ]
    PRINTSi PR00723. SUBTILISIN.
    SUPFAMi SSF49785. SSF49785. 1 hit.
    SSF52743. SSF52743. 1 hit.
    SSF54897. SSF54897. 1 hit.
    PROSITEi PS00136. SUBTILASE_ASP. 1 hit.
    PS00137. SUBTILASE_HIS. 1 hit.
    PS00138. SUBTILASE_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning, ontogeny and tissue distribution of zebrafish (Danio rerio) prohormone convertases: pcsk1 and pcsk2."
      Morash M.G., MacDonald A.B., Croll R.P., Anini Y.
      Gen. Comp. Endocrinol. 162:179-187(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiB6VCA2_DANRE
    AccessioniPrimary (citable) accession number: B6VCA2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 16, 2008
    Last sequence update: December 16, 2008
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)