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Protein
Submitted name:

Prohormone convertase 1

Gene

pcsk1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Serine proteaseUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-DRE-209952. Peptide hormone biosynthesis.
R-DRE-264876. Insulin processing.

Protein family/group databases

MEROPSiS08.072.

Names & Taxonomyi

Protein namesi
Submitted name:
Prohormone convertase 1Imported
Submitted name:
Proprotein convertase subtilisin/kexin type 1Imported
Gene namesi
Name:pcsk1Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 21

Organism-specific databases

ZFINiZDB-GENE-071009-1. pcsk1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_501010701124 – 755Sequence analysisAdd BLAST732

Expressioni

Gene expression databases

BgeeiENSDARG00000002600.
ExpressionAtlasiB6VCA1. baseline.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000004083.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 108S8_pro-domainInterPro annotationAdd BLAST77
Domaini161 – 445Peptidase S8InterPro annotationAdd BLAST285
Domaini507 – 594P_proproteinInterPro annotationAdd BLAST88
Domaini714 – 752Proho_convertInterPro annotationAdd BLAST39

Sequence similaritiesi

Belongs to the peptidase S8 family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG3525. Eukaryota.
COG1404. LUCA.
COG4935. LUCA.
GeneTreeiENSGT00750000117358.
HOGENOMiHOG000192536.
HOVERGENiHBG008705.
KOiK01359.
OMAiFEPRALK.
OrthoDBiEOG091G05HI.
TreeFamiTF314277.

Family and domain databases

CDDicd04059. Peptidases_S8_Protein_converta. 1 hit.
Gene3Di2.60.120.260. 1 hit.
3.40.50.200. 1 hit.
InterProiView protein in InterPro
IPR008979. Galactose-bd-like.
IPR034182. Kexin/furin.
IPR009020. Peptidase/Inhibitor_I9.
IPR000209. Peptidase_S8/S53_dom.
IPR023827. Peptidase_S8_Asp-AS.
IPR022398. Peptidase_S8_His-AS.
IPR023828. Peptidase_S8_Ser-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR022005. Proho_convert.
IPR002884. PrprotnconvertsP.
IPR032815. S8_pro-domain.
PfamiView protein in Pfam
PF01483. P_proprotein. 1 hit.
PF00082. Peptidase_S8. 1 hit.
PF12177. Proho_convert. 1 hit.
PF16470. S8_pro-domain. 1 hit.
PRINTSiPR00723. SUBTILISIN.
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF52743. SSF52743. 1 hit.
SSF54897. SSF54897. 1 hit.
PROSITEiView protein in PROSITE
PS00136. SUBTILASE_ASP. 1 hit.
PS00137. SUBTILASE_HIS. 1 hit.
PS00138. SUBTILASE_SER. 1 hit.

Sequencei

Sequence statusi: Complete.

B6VCA1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEERCRPMLL CSVLALVCAL VSSAVDRQYL NEWAVEIPGG VQNARSIADE
60 70 80 90 100
FGYQLVRQIG ALENHYLFKR HSHPSRTKRS ADHITKRLSE DDRVSWAEQQ
110 120 130 140 150
YEKRRAKRAP LGVECKDCSV DKLFDDPMWN QQWYLQDTRT SSSLPKLDLH
160 170 180 190 200
VIPVWKKGIT GKGVVITVLD DGLEWNHTDI YPNYDPAASY DFNDNDPDPF
210 220 230 240 250
PRYDSTNENK HGTRCAGEIA MQADNNKCGV GVAYNSKVGG IRMLDGIVTD
260 270 280 290 300
AIEASSIGYN PDHVDIYSAS WGPNDDGKTV EGPGRLAQKA FEYGIQKGRG
310 320 330 340 350
GKGSIFVWAS GNGGRQGDNC DCDGYTDSLY TISISSASQQ GLSPWYAEKC
360 370 380 390 400
SSTLATAYSS GDYTDQRITS ADLHNECTET HTGTSASAPL AAGIFALALE
410 420 430 440 450
QNPDLTWRDL QHLVVWTSEF DPLANNPGWK RNGAGLMVNS RFGFGLLNAK
460 470 480 490 500
ALVDLADPKV WKHVPEKKQC IVRDETFQPR PLKAAGEISI EIPTKACAGQ
510 520 530 540 550
ANSVMSLEHV QVEVSIEYTR RGDLHITLTS PSGTTTVLLA ERERDTSSNG
560 570 580 590 600
FRNWAFMSVH TWGENPTGTW ILKITDTSGR MENEGQIISW KLILHGTSEK
610 620 630 640 650
PEHMKKARVY TPYNAVQNDR RGVEPMEDMM KQEAPTPALK PEIPNQAIPD
660 670 680 690 700
SPPSTASMSI PEVNSGPSTA NLALLRLLQS AFNRQMPAAP PKSFQQERIP
710 720 730 740 750
PQKLYQALDL LNRYRASQNG LFNDYSDNFY RAQPYRHRDD RLLQALFDML

RDDQQ
Length:755
Mass (Da):84,203
Last modified:December 16, 2008 - v1
Checksum:i137AF7F3B67E27B9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX511081 Genomic DNA. No translation available.
FJ373314 mRNA. Translation: ACJ05352.1.
RefSeqiNP_001131134.1. NM_001137662.1.
UniGeneiDr.89425.

Genome annotation databases

EnsembliENSDART00000014668; ENSDARP00000004083; ENSDARG00000002600.
GeneIDi100005716.
KEGGidre:100005716.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiB6VCA1_DANRE
AccessioniPrimary (citable) accession number: B6VCA1
Entry historyiIntegrated into UniProtKB/TrEMBL: December 16, 2008
Last sequence update: December 16, 2008
Last modified: July 5, 2017
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported