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B6VCA1

- B6VCA1_DANRE

UniProt

B6VCA1 - B6VCA1_DANRE

Protein
Submitted name:

Prohormone convertase 1

Gene

pcsk1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (16 Dec 2008)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. serine-type endopeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine proteaseUniRule annotationSAAS annotation

    Protein family/group databases

    MEROPSiS08.072.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Prohormone convertase 1Imported
    Submitted name:
    Uncharacterized proteinImported
    Gene namesi
    Name:pcsk1Imported
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 21

    Organism-specific databases

    ZFINiZDB-GENE-071009-1. pcsk1.

    Interactioni

    Protein-protein interaction databases

    STRINGi7955.ENSDARP00000004083.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S8 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG4935.
    GeneTreeiENSGT00750000117689.
    HOGENOMiHOG000192536.
    HOVERGENiHBG008705.
    KOiK01359.
    OMAiNNPGWKK.
    TreeFamiTF314277.

    Family and domain databases

    Gene3Di2.60.120.260. 1 hit.
    3.40.50.200. 1 hit.
    InterProiIPR008979. Galactose-bd-like.
    IPR000209. Peptidase_S8/S53_dom.
    IPR023827. Peptidase_S8_Asp-AS.
    IPR022398. Peptidase_S8_His-AS.
    IPR023828. Peptidase_S8_Ser-AS.
    IPR015500. Peptidase_S8_subtilisin-rel.
    IPR022005. Proho_convert.
    IPR009020. Prot_inh_propept.
    IPR002884. PrprotnconvertsP.
    [Graphical view]
    PANTHERiPTHR10795. PTHR10795. 1 hit.
    PfamiPF01483. P_proprotein. 1 hit.
    PF00082. Peptidase_S8. 1 hit.
    PF12177. Proho_convert. 1 hit.
    [Graphical view]
    PRINTSiPR00723. SUBTILISIN.
    SUPFAMiSSF49785. SSF49785. 1 hit.
    SSF52743. SSF52743. 1 hit.
    SSF54897. SSF54897. 1 hit.
    PROSITEiPS00136. SUBTILASE_ASP. 1 hit.
    PS00137. SUBTILASE_HIS. 1 hit.
    PS00138. SUBTILASE_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B6VCA1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEERCRPMLL CSVLALVCAL VSSAVDRQYL NEWAVEIPGG VQNARSIADE    50
    FGYQLVRQIG ALENHYLFKR HSHPSRTKRS ADHITKRLSE DDRVSWAEQQ 100
    YEKRRAKRAP LGVECKDCSV DKLFDDPMWN QQWYLQDTRT SSSLPKLDLH 150
    VIPVWKKGIT GKGVVITVLD DGLEWNHTDI YPNYDPAASY DFNDNDPDPF 200
    PRYDSTNENK HGTRCAGEIA MQADNNKCGV GVAYNSKVGG IRMLDGIVTD 250
    AIEASSIGYN PDHVDIYSAS WGPNDDGKTV EGPGRLAQKA FEYGIQKGRG 300
    GKGSIFVWAS GNGGRQGDNC DCDGYTDSLY TISISSASQQ GLSPWYAEKC 350
    SSTLATAYSS GDYTDQRITS ADLHNECTET HTGTSASAPL AAGIFALALE 400
    QNPDLTWRDL QHLVVWTSEF DPLANNPGWK RNGAGLMVNS RFGFGLLNAK 450
    ALVDLADPKV WKHVPEKKQC IVRDETFQPR PLKAAGEISI EIPTKACAGQ 500
    ANSVMSLEHV QVEVSIEYTR RGDLHITLTS PSGTTTVLLA ERERDTSSNG 550
    FRNWAFMSVH TWGENPTGTW ILKITDTSGR MENEGQIISW KLILHGTSEK 600
    PEHMKKARVY TPYNAVQNDR RGVEPMEDMM KQEAPTPALK PEIPNQAIPD 650
    SPPSTASMSI PEVNSGPSTA NLALLRLLQS AFNRQMPAAP PKSFQQERIP 700
    PQKLYQALDL LNRYRASQNG LFNDYSDNFY RAQPYRHRDD RLLQALFDML 750
    RDDQQ 755
    Length:755
    Mass (Da):84,203
    Last modified:December 16, 2008 - v1
    Checksum:i137AF7F3B67E27B9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX511081 Genomic DNA. No translation available.
    FJ373314 mRNA. Translation: ACJ05352.1.
    RefSeqiNP_001131134.1. NM_001137662.1.
    UniGeneiDr.89425.

    Genome annotation databases

    EnsembliENSDART00000014668; ENSDARP00000004083; ENSDARG00000002600.
    GeneIDi100005716.
    KEGGidre:100005716.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX511081 Genomic DNA. No translation available.
    FJ373314 mRNA. Translation: ACJ05352.1 .
    RefSeqi NP_001131134.1. NM_001137662.1.
    UniGenei Dr.89425.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7955.ENSDARP00000004083.

    Protein family/group databases

    MEROPSi S08.072.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000014668 ; ENSDARP00000004083 ; ENSDARG00000002600 .
    GeneIDi 100005716.
    KEGGi dre:100005716.

    Organism-specific databases

    CTDi 5122.
    ZFINi ZDB-GENE-071009-1. pcsk1.

    Phylogenomic databases

    eggNOGi COG4935.
    GeneTreei ENSGT00750000117689.
    HOGENOMi HOG000192536.
    HOVERGENi HBG008705.
    KOi K01359.
    OMAi NNPGWKK.
    TreeFami TF314277.

    Miscellaneous databases

    NextBioi 20786807.
    PROi B6VCA1.

    Family and domain databases

    Gene3Di 2.60.120.260. 1 hit.
    3.40.50.200. 1 hit.
    InterProi IPR008979. Galactose-bd-like.
    IPR000209. Peptidase_S8/S53_dom.
    IPR023827. Peptidase_S8_Asp-AS.
    IPR022398. Peptidase_S8_His-AS.
    IPR023828. Peptidase_S8_Ser-AS.
    IPR015500. Peptidase_S8_subtilisin-rel.
    IPR022005. Proho_convert.
    IPR009020. Prot_inh_propept.
    IPR002884. PrprotnconvertsP.
    [Graphical view ]
    PANTHERi PTHR10795. PTHR10795. 1 hit.
    Pfami PF01483. P_proprotein. 1 hit.
    PF00082. Peptidase_S8. 1 hit.
    PF12177. Proho_convert. 1 hit.
    [Graphical view ]
    PRINTSi PR00723. SUBTILISIN.
    SUPFAMi SSF49785. SSF49785. 1 hit.
    SSF52743. SSF52743. 1 hit.
    SSF54897. SSF54897. 1 hit.
    PROSITEi PS00136. SUBTILASE_ASP. 1 hit.
    PS00137. SUBTILASE_HIS. 1 hit.
    PS00138. SUBTILASE_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning, ontogeny and tissue distribution of zebrafish (Danio rerio) prohormone convertases: pcsk1 and pcsk2."
      Morash M.G., MacDonald A.B., Croll R.P., Anini Y.
      Gen. Comp. Endocrinol. 162:179-187(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: TuebingenImported.
    3. "The zebrafish reference genome sequence and its relationship to the human genome."
      Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
      , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
      Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TuebingenImported.

    Entry informationi

    Entry nameiB6VCA1_DANRE
    AccessioniPrimary (citable) accession number: B6VCA1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 16, 2008
    Last sequence update: December 16, 2008
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3