Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Prohormone convertase 1

Gene

pcsk1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Serine proteaseUniRule annotation

Enzyme and pathway databases

ReactomeiR-DRE-209952 Peptide hormone biosynthesis

Protein family/group databases

MEROPSiS08.072

Names & Taxonomyi

Protein namesi
Submitted name:
Prohormone convertase 1Imported
Submitted name:
Proprotein convertase subtilisin/kexin type 1Imported
Gene namesi
Name:pcsk1Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 21

Organism-specific databases

ZFINiZDB-GENE-071009-1 pcsk1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_501456779624 – 755Sequence analysisAdd BLAST732

Expressioni

Gene expression databases

BgeeiENSDARG00000002600

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000004083

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini463 – 600P/Homo BInterPro annotationAdd BLAST138

Sequence similaritiesi

Belongs to the peptidase S8 family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG3525 Eukaryota
COG1404 LUCA
COG4935 LUCA
GeneTreeiENSGT00750000117358
HOGENOMiHOG000192536
HOVERGENiHBG008705
KOiK01359
OrthoDBiEOG091G05HI
TreeFamiTF314277

Family and domain databases

CDDicd04059 Peptidases_S8_Protein_converta, 1 hit
Gene3Di2.60.120.260, 1 hit
3.30.70.850, 1 hit
3.40.50.200, 1 hit
InterProiView protein in InterPro
IPR008979 Galactose-bd-like_sf
IPR034182 Kexin/furin
IPR002884 P_dom
IPR000209 Peptidase_S8/S53_dom
IPR036852 Peptidase_S8/S53_dom_sf
IPR023827 Peptidase_S8_Asp-AS
IPR022398 Peptidase_S8_His-AS
IPR023828 Peptidase_S8_Ser-AS
IPR015500 Peptidase_S8_subtilisin-rel
IPR022005 Proho_convert
IPR032815 S8_pro-domain
IPR038466 S8_pro-domain_sf
PfamiView protein in Pfam
PF01483 P_proprotein, 1 hit
PF00082 Peptidase_S8, 1 hit
PF12177 Proho_convert, 1 hit
PF16470 S8_pro-domain, 1 hit
PRINTSiPR00723 SUBTILISIN
SUPFAMiSSF49785 SSF49785, 1 hit
SSF52743 SSF52743, 1 hit
PROSITEiView protein in PROSITE
PS51829 P_HOMO_B, 1 hit
PS00136 SUBTILASE_ASP, 1 hit
PS00137 SUBTILASE_HIS, 1 hit
PS00138 SUBTILASE_SER, 1 hit

Sequencei

Sequence statusi: Complete.

B6VCA1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEERCRPMLL CSVLALVCAL VSSAVDRQYL NEWAVEIPGG VQNARSIADE
60 70 80 90 100
FGYQLVRQIG ALENHYLFKR HSHPSRTKRS ADHITKRLSE DDRVSWAEQQ
110 120 130 140 150
YEKRRAKRAP LGVECKDCSV DKLFDDPMWN QQWYLQDTRT SSSLPKLDLH
160 170 180 190 200
VIPVWKKGIT GKGVVITVLD DGLEWNHTDI YPNYDPAASY DFNDNDPDPF
210 220 230 240 250
PRYDSTNENK HGTRCAGEIA MQADNNKCGV GVAYNSKVGG IRMLDGIVTD
260 270 280 290 300
AIEASSIGYN PDHVDIYSAS WGPNDDGKTV EGPGRLAQKA FEYGIQKGRG
310 320 330 340 350
GKGSIFVWAS GNGGRQGDNC DCDGYTDSLY TISISSASQQ GLSPWYAEKC
360 370 380 390 400
SSTLATAYSS GDYTDQRITS ADLHNECTET HTGTSASAPL AAGIFALALE
410 420 430 440 450
QNPDLTWRDL QHLVVWTSEF DPLANNPGWK RNGAGLMVNS RFGFGLLNAK
460 470 480 490 500
ALVDLADPKV WKHVPEKKQC IVRDETFQPR PLKAAGEISI EIPTKACAGQ
510 520 530 540 550
ANSVMSLEHV QVEVSIEYTR RGDLHITLTS PSGTTTVLLA ERERDTSSNG
560 570 580 590 600
FRNWAFMSVH TWGENPTGTW ILKITDTSGR MENEGQIISW KLILHGTSEK
610 620 630 640 650
PEHMKKARVY TPYNAVQNDR RGVEPMEDMM KQEAPTPALK PEIPNQAIPD
660 670 680 690 700
SPPSTASMSI PEVNSGPSTA NLALLRLLQS AFNRQMPAAP PKSFQQERIP
710 720 730 740 750
PQKLYQALDL LNRYRASQNG LFNDYSDNFY RAQPYRHRDD RLLQALFDML

RDDQQ
Length:755
Mass (Da):84,203
Last modified:December 16, 2008 - v1
Checksum:i137AF7F3B67E27B9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX511081 Genomic DNA No translation available.
FJ373314 mRNA Translation: ACJ05352.1
RefSeqiNP_001131134.1, NM_001137662.1
UniGeneiDr.89425

Genome annotation databases

EnsembliENSDART00000014668; ENSDARP00000004083; ENSDARG00000002600
GeneIDi100005716
KEGGidre:100005716

Similar proteinsi

Entry informationi

Entry nameiB6VCA1_DANRE
AccessioniPrimary (citable) accession number: B6VCA1
Entry historyiIntegrated into UniProtKB/TrEMBL: December 16, 2008
Last sequence update: December 16, 2008
Last modified: May 23, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health