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B6VCA1

- B6VCA1_DANRE

UniProt

B6VCA1 - B6VCA1_DANRE

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Protein
Submitted name: Prohormone convertase 1
Gene
pcsk1
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine proteaseUniRule annotationSAAS annotations

Protein family/group databases

MEROPSiS08.072.

Names & Taxonomyi

Protein namesi
Submitted name:
Prohormone convertase 1Imported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:pcsk1Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Chromosome 21

Organism-specific databases

ZFINiZDB-GENE-071009-1. pcsk1.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000004083.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S8 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG4935.
GeneTreeiENSGT00750000117689.
HOGENOMiHOG000192536.
HOVERGENiHBG008705.
KOiK01359.
OMAiNNPGWKK.
TreeFamiTF314277.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
3.40.50.200. 1 hit.
InterProiIPR008979. Galactose-bd-like.
IPR000209. Peptidase_S8/S53_dom.
IPR023827. Peptidase_S8_Asp-AS.
IPR022398. Peptidase_S8_His-AS.
IPR023828. Peptidase_S8_Ser-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR022005. Proho_convert.
IPR009020. Prot_inh_propept.
IPR002884. PrprotnconvertsP.
[Graphical view]
PANTHERiPTHR10795. PTHR10795. 1 hit.
PfamiPF01483. P_proprotein. 1 hit.
PF00082. Peptidase_S8. 1 hit.
PF12177. Proho_convert. 1 hit.
[Graphical view]
PRINTSiPR00723. SUBTILISIN.
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF52743. SSF52743. 1 hit.
SSF54897. SSF54897. 1 hit.
PROSITEiPS00136. SUBTILASE_ASP. 1 hit.
PS00137. SUBTILASE_HIS. 1 hit.
PS00138. SUBTILASE_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B6VCA1-1 [UniParc]FASTAAdd to Basket

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MEERCRPMLL CSVLALVCAL VSSAVDRQYL NEWAVEIPGG VQNARSIADE    50
FGYQLVRQIG ALENHYLFKR HSHPSRTKRS ADHITKRLSE DDRVSWAEQQ 100
YEKRRAKRAP LGVECKDCSV DKLFDDPMWN QQWYLQDTRT SSSLPKLDLH 150
VIPVWKKGIT GKGVVITVLD DGLEWNHTDI YPNYDPAASY DFNDNDPDPF 200
PRYDSTNENK HGTRCAGEIA MQADNNKCGV GVAYNSKVGG IRMLDGIVTD 250
AIEASSIGYN PDHVDIYSAS WGPNDDGKTV EGPGRLAQKA FEYGIQKGRG 300
GKGSIFVWAS GNGGRQGDNC DCDGYTDSLY TISISSASQQ GLSPWYAEKC 350
SSTLATAYSS GDYTDQRITS ADLHNECTET HTGTSASAPL AAGIFALALE 400
QNPDLTWRDL QHLVVWTSEF DPLANNPGWK RNGAGLMVNS RFGFGLLNAK 450
ALVDLADPKV WKHVPEKKQC IVRDETFQPR PLKAAGEISI EIPTKACAGQ 500
ANSVMSLEHV QVEVSIEYTR RGDLHITLTS PSGTTTVLLA ERERDTSSNG 550
FRNWAFMSVH TWGENPTGTW ILKITDTSGR MENEGQIISW KLILHGTSEK 600
PEHMKKARVY TPYNAVQNDR RGVEPMEDMM KQEAPTPALK PEIPNQAIPD 650
SPPSTASMSI PEVNSGPSTA NLALLRLLQS AFNRQMPAAP PKSFQQERIP 700
PQKLYQALDL LNRYRASQNG LFNDYSDNFY RAQPYRHRDD RLLQALFDML 750
RDDQQ 755
Length:755
Mass (Da):84,203
Last modified:December 16, 2008 - v1
Checksum:i137AF7F3B67E27B9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX511081 Genomic DNA. No translation available.
FJ373314 mRNA. Translation: ACJ05352.1.
RefSeqiNP_001131134.1. NM_001137662.1.
UniGeneiDr.89425.

Genome annotation databases

EnsembliENSDART00000014668; ENSDARP00000004083; ENSDARG00000002600.
GeneIDi100005716.
KEGGidre:100005716.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX511081 Genomic DNA. No translation available.
FJ373314 mRNA. Translation: ACJ05352.1 .
RefSeqi NP_001131134.1. NM_001137662.1.
UniGenei Dr.89425.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7955.ENSDARP00000004083.

Protein family/group databases

MEROPSi S08.072.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSDART00000014668 ; ENSDARP00000004083 ; ENSDARG00000002600 .
GeneIDi 100005716.
KEGGi dre:100005716.

Organism-specific databases

CTDi 5122.
ZFINi ZDB-GENE-071009-1. pcsk1.

Phylogenomic databases

eggNOGi COG4935.
GeneTreei ENSGT00750000117689.
HOGENOMi HOG000192536.
HOVERGENi HBG008705.
KOi K01359.
OMAi NNPGWKK.
TreeFami TF314277.

Miscellaneous databases

NextBioi 20786807.
PROi B6VCA1.

Family and domain databases

Gene3Di 2.60.120.260. 1 hit.
3.40.50.200. 1 hit.
InterProi IPR008979. Galactose-bd-like.
IPR000209. Peptidase_S8/S53_dom.
IPR023827. Peptidase_S8_Asp-AS.
IPR022398. Peptidase_S8_His-AS.
IPR023828. Peptidase_S8_Ser-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR022005. Proho_convert.
IPR009020. Prot_inh_propept.
IPR002884. PrprotnconvertsP.
[Graphical view ]
PANTHERi PTHR10795. PTHR10795. 1 hit.
Pfami PF01483. P_proprotein. 1 hit.
PF00082. Peptidase_S8. 1 hit.
PF12177. Proho_convert. 1 hit.
[Graphical view ]
PRINTSi PR00723. SUBTILISIN.
SUPFAMi SSF49785. SSF49785. 1 hit.
SSF52743. SSF52743. 1 hit.
SSF54897. SSF54897. 1 hit.
PROSITEi PS00136. SUBTILASE_ASP. 1 hit.
PS00137. SUBTILASE_HIS. 1 hit.
PS00138. SUBTILASE_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning, ontogeny and tissue distribution of zebrafish (Danio rerio) prohormone convertases: pcsk1 and pcsk2."
    Morash M.G., MacDonald A.B., Croll R.P., Anini Y.
    Gen. Comp. Endocrinol. 162:179-187(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: TuebingenImported.
  3. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TuebingenImported.

Entry informationi

Entry nameiB6VCA1_DANRE
AccessioniPrimary (citable) accession number: B6VCA1
Entry historyi
Integrated into UniProtKB/TrEMBL: December 16, 2008
Last sequence update: December 16, 2008
Last modified: May 14, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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