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B6V867

- SCPA_TRITO

UniProt

B6V867 - SCPA_TRITO

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Protein
Carboxypeptidase S1 homolog A
Gene
SCPA
Organism
Trichophyton tonsurans (Scalp ringworm fungus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Extracellular serine carboxypeptidase that contributes to pathogenicity By similarity.

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei238 – 2381 By similarity
Active sitei458 – 4581 By similarity
Binding sitei461 – 4611Substrate By similarity
Active sitei516 – 5161 By similarity
Binding sitei517 – 5171Substrate By similarity

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro

GO - Biological processi

  1. pathogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Virulence

Protein family/group databases

MEROPSiS10.016.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase S1 homolog A (EC:3.4.16.6)
Alternative name(s):
Serine carboxypeptidase A
Short name:
SPCA
Gene namesi
Name:SCPA
OrganismiTrichophyton tonsurans (Scalp ringworm fungus)
Taxonomic identifieri34387 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaemitosporic ArthrodermataceaeTrichophyton

Subcellular locationi

Cell membrane; Lipid-anchorGPI-anchor Reviewed prediction

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed prediction
Add
BLAST
Chaini20 – 629610Carboxypeptidase S1 homolog A
PRO_0000384119Add
BLAST
Propeptidei630 – 65122Removed in mature form Reviewed prediction
PRO_0000384120Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi50 ↔ 121 By similarity
Glycosylationi77 – 771N-linked (GlcNAc...) Reviewed prediction
Glycosylationi132 – 1321N-linked (GlcNAc...) Reviewed prediction
Glycosylationi161 – 1611N-linked (GlcNAc...) Reviewed prediction
Glycosylationi168 – 1681N-linked (GlcNAc...) Reviewed prediction
Glycosylationi184 – 1841N-linked (GlcNAc...) Reviewed prediction
Glycosylationi202 – 2021N-linked (GlcNAc...) Reviewed prediction
Glycosylationi260 – 2601N-linked (GlcNAc...) Reviewed prediction
Glycosylationi299 – 2991N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi325 ↔ 361 By similarity
Disulfide bondi332 ↔ 354 By similarity
Glycosylationi347 – 3471N-linked (GlcNAc...) Reviewed prediction
Glycosylationi410 – 4101N-linked (GlcNAc...) Reviewed prediction
Glycosylationi474 – 4741N-linked (GlcNAc...) Reviewed prediction
Glycosylationi492 – 4921N-linked (GlcNAc...) Reviewed prediction
Glycosylationi505 – 5051N-linked (GlcNAc...) Reviewed prediction
Lipidationi629 – 6291GPI-anchor amidated glycine Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 2 hits.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B6V867-1 [UniParc]FASTAAdd to Basket

« Hide

MRFAASIAVA LPVIGAASAQ GFPPPVEGVT VVKSKFDENV KITYKENDIC    50
ETTEGVRSFT GHVHLPPDDN DFGVYRNYSI NTFFWFFEAR EDPKNAPLSI 100
WLNGGPGSSS MIGLFQENGP CWINDDSKST TNNTFSWNNK VNMLYIDQPN 150
QVGFSYDELT NITYSTINDT VYVADFSNGV PAQNLSTLVG TGSSQNPWAT 200
ANNTVNAARS IWHFAQVWFQ EFPEHKPNNN KISIWTESYG GRYGPSFASY 250
FQEQNEKIKN HTITEEGEMH ILNLDTLGII NGCIDLMFQA ESYAEFPYNN 300
TYGITAYTKE KYDAIIHDIH RPDGCFDKLA KCREAAKEGD PHFYSNNATV 350
NAICADASSS CDNYLMDPYQ ETNLGYYDIA HPLQDPFPPP FYKGFLSQSS 400
VLSDMGSPVN FTQYAQAVGK SFHGVGDYAR PDVRGFTGDI AYLLESGVKV 450
ALVYGDRDYI CNWIGGEQVS LGLNYTGTAE FHRAGYADVK VNSSYVGGLV 500
RQHGNFSFTR VFEAGHEVPG YQPETSLKIF ERIMFNKDIA TGELDIAQKP 550
DYGTTGTEST FQVKNEIPPS PEPTCYLLSA DGTCTQEQLK AIKEGTAVVE 600
NYIIKSPAAS KGDPPPTTTT SPTAAPTAGS AMLQAPVAML AISVLTALAF 650
L 651
Length:651
Mass (Da):71,592
Last modified:December 16, 2008 - v1
Checksum:iEE400CAC4FEE037A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FJ267690 Genomic DNA. Translation: ACJ06658.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FJ267690 Genomic DNA. Translation: ACJ06658.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S10.016.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.1820. 2 hits.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 2 hits.
PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparing putative pathogenicity factors between Trichophyton tonsurans and Trichophyton equinum."
    Preuett B.L., Abdel-Rahman S.M.
    Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiSCPA_TRITO
AccessioniPrimary (citable) accession number: B6V867
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: December 16, 2008
Last modified: June 11, 2014
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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