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Protein

Carboxypeptidase S1 homolog A

Gene

SCPA

Organism
Trichophyton tonsurans (Scalp ringworm fungus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Extracellular serine carboxypeptidase that contributes to pathogenicity.By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei238 – 2381PROSITE-ProRule annotation
Active sitei458 – 4581PROSITE-ProRule annotation
Binding sitei461 – 4611SubstrateBy similarity
Active sitei516 – 5161PROSITE-ProRule annotation
Binding sitei517 – 5171SubstrateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Virulence

Protein family/group databases

ESTHERitriru-SPCA. Carboxypeptidase_S10.
MEROPSiS10.A48.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase S1 homolog A (EC:3.4.16.6)
Alternative name(s):
Serine carboxypeptidase A
Short name:
SPCA
Gene namesi
Name:SCPA
OrganismiTrichophyton tonsurans (Scalp ringworm fungus)
Taxonomic identifieri34387 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaeTrichophyton

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 629610Carboxypeptidase S1 homolog APRO_0000384119Add
BLAST
Propeptidei630 – 65122Removed in mature formSequence AnalysisPRO_0000384120Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi50 ↔ 121By similarity
Glycosylationi77 – 771N-linked (GlcNAc...)Sequence Analysis
Glycosylationi132 – 1321N-linked (GlcNAc...)Sequence Analysis
Glycosylationi161 – 1611N-linked (GlcNAc...)Sequence Analysis
Glycosylationi168 – 1681N-linked (GlcNAc...)Sequence Analysis
Glycosylationi184 – 1841N-linked (GlcNAc...)Sequence Analysis
Glycosylationi202 – 2021N-linked (GlcNAc...)Sequence Analysis
Glycosylationi260 – 2601N-linked (GlcNAc...)Sequence Analysis
Glycosylationi299 – 2991N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi325 ↔ 361By similarity
Disulfide bondi332 ↔ 354By similarity
Glycosylationi347 – 3471N-linked (GlcNAc...)Sequence Analysis
Glycosylationi410 – 4101N-linked (GlcNAc...)Sequence Analysis
Glycosylationi474 – 4741N-linked (GlcNAc...)Sequence Analysis
Glycosylationi492 – 4921N-linked (GlcNAc...)Sequence Analysis
Glycosylationi505 – 5051N-linked (GlcNAc...)Sequence Analysis
Lipidationi629 – 6291GPI-anchor amidated glycineSequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 2 hits.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B6V867-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRFAASIAVA LPVIGAASAQ GFPPPVEGVT VVKSKFDENV KITYKENDIC
60 70 80 90 100
ETTEGVRSFT GHVHLPPDDN DFGVYRNYSI NTFFWFFEAR EDPKNAPLSI
110 120 130 140 150
WLNGGPGSSS MIGLFQENGP CWINDDSKST TNNTFSWNNK VNMLYIDQPN
160 170 180 190 200
QVGFSYDELT NITYSTINDT VYVADFSNGV PAQNLSTLVG TGSSQNPWAT
210 220 230 240 250
ANNTVNAARS IWHFAQVWFQ EFPEHKPNNN KISIWTESYG GRYGPSFASY
260 270 280 290 300
FQEQNEKIKN HTITEEGEMH ILNLDTLGII NGCIDLMFQA ESYAEFPYNN
310 320 330 340 350
TYGITAYTKE KYDAIIHDIH RPDGCFDKLA KCREAAKEGD PHFYSNNATV
360 370 380 390 400
NAICADASSS CDNYLMDPYQ ETNLGYYDIA HPLQDPFPPP FYKGFLSQSS
410 420 430 440 450
VLSDMGSPVN FTQYAQAVGK SFHGVGDYAR PDVRGFTGDI AYLLESGVKV
460 470 480 490 500
ALVYGDRDYI CNWIGGEQVS LGLNYTGTAE FHRAGYADVK VNSSYVGGLV
510 520 530 540 550
RQHGNFSFTR VFEAGHEVPG YQPETSLKIF ERIMFNKDIA TGELDIAQKP
560 570 580 590 600
DYGTTGTEST FQVKNEIPPS PEPTCYLLSA DGTCTQEQLK AIKEGTAVVE
610 620 630 640 650
NYIIKSPAAS KGDPPPTTTT SPTAAPTAGS AMLQAPVAML AISVLTALAF

L
Length:651
Mass (Da):71,592
Last modified:December 16, 2008 - v1
Checksum:iEE400CAC4FEE037A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ267690 Genomic DNA. Translation: ACJ06658.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ267690 Genomic DNA. Translation: ACJ06658.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

ESTHERitriru-SPCA. Carboxypeptidase_S10.
MEROPSiS10.A48.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 2 hits.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Comparing putative pathogenicity factors between Trichophyton tonsurans and Trichophyton equinum."
    Preuett B.L., Abdel-Rahman S.M.
    Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiSCPA_TRITO
AccessioniPrimary (citable) accession number: B6V867
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: December 16, 2008
Last modified: June 24, 2015
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.