Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Lactoylglutathione lyase

Gene

100280481

Organism
Zea mays (Maize)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.UniRule annotation

Catalytic activityi

(R)-S-lactoylglutathione = glutathione + methylglyoxal.UniRule annotation

Cofactori

Zn2+UniRule annotation

Pathwayi: methylglyoxal degradation

This protein is involved in step 1 of the subpathway that synthesizes (R)-lactate from methylglyoxal.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Lactoylglutathione lyase, Lactoylglutathione lyase, Lactoylglutathione lyase (100280481), Lactoylglutathione lyase (100280481), Lactoylglutathione lyase (100280481), Lactoylglutathione lyase (100191237), Lactoylglutathione lyase, Lactoylglutathione lyase (100191237), Lactoylglutathione lyase (100191237), Lactoylglutathione lyase (GlxI), Lactoylglutathione lyase (100191237)
  2. no protein annotated in this organism
This subpathway is part of the pathway methylglyoxal degradation, which is itself part of Secondary metabolite metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-lactate from methylglyoxal, the pathway methylglyoxal degradation and in Secondary metabolite metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotationImported
LigandMetal-bindingUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00619; UER00675

Names & Taxonomyi

Protein namesi
Recommended name:
Lactoylglutathione lyaseUniRule annotation (EC:4.4.1.5UniRule annotation)
Alternative name(s):
Glyoxalase IUniRule annotation
Gene namesi
Name:100280481Imported
ORF Names:ZEAMMB73_Zm00001d004123Imported
OrganismiZea mays (Maize)Imported
Taxonomic identifieri4577 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogonodaeAndropogoneaeTripsacinaeZea
Proteomesi
  • UP000007305 Componenti: Chromosome 2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PaxDbiB6SGV9
PRIDEiB6SGV9

Expressioni

Gene expression databases

ExpressionAtlasiB6SGV9 differential

Interactioni

Protein-protein interaction databases

STRINGi4577.GRMZM2G125310_P01

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini65 – 212VOCInterPro annotationAdd BLAST148

Sequence similaritiesi

Belongs to the glyoxalase I family.UniRule annotation

Phylogenomic databases

eggNOGiENOG410IU7X Eukaryota
ENOG4111FDV LUCA
HOGENOMiHOG000232011
KOiK01759
OMAiWMKSIPG
OrthoDBiEOG09360O07

Family and domain databases

Gene3Di3.10.180.10, 1 hit
InterProiView protein in InterPro
IPR029068 Glyas_Bleomycin-R_OHBP_Dase
IPR004360 Glyas_Fos-R_dOase_dom
IPR004361 Glyoxalase_1
IPR018146 Glyoxalase_1_CS
IPR037523 VOC
PfamiView protein in Pfam
PF00903 Glyoxalase, 1 hit
SUPFAMiSSF54593 SSF54593, 1 hit
TIGRFAMsiTIGR00068 glyox_I, 1 hit
PROSITEiView protein in PROSITE
PS00934 GLYOXALASE_I_1, 1 hit
PS00935 GLYOXALASE_I_2, 1 hit
PS51819 VOC, 1 hit

Sequencei

Sequence statusi: Complete.

B6SGV9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGASLLSPS CTLLRLIPSA SHFKRFDRVR RFAPAAMATS SGPKEAPANN
60 70 80 90 100
PGLQTEVDPA TKGYFLQQTM LRVKDPKVSL DFYSRVMGMS LLKRLDFEEM
110 120 130 140 150
KFSLYFLGYE DVTLAPDDHI KRTEWTFRQK ATLELTHNWG TENDPEFKGY
160 170 180 190 200
HNGNSDPRGF GHIGVTVDDV HKACERFERL GVEFVKKPDD GKIKGIAFIK
210 220
DPDGYWIEIF DQTIGTVTSS AS
Length:222
Mass (Da):24,987
Last modified:December 16, 2008 - v1
Checksum:i6580598480DB24C3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU951974 mRNA Translation: ACG24092.1
CM007648 Genomic DNA Translation: ONM18363.1
RefSeqiNP_001146873.1, NM_001153401.1
UniGeneiZm.94328

Genome annotation databases

EnsemblPlantsiZm00001d004123_T001; Zm00001d004123_P001; Zm00001d004123
GeneIDi100280481
GrameneiZm00001d004123_T001; Zm00001d004123_P001; Zm00001d004123
KEGGizma:100280481

Similar proteinsi

Entry informationi

Entry nameiB6SGV9_MAIZE
AccessioniPrimary (citable) accession number: B6SGV9
Entry historyiIntegrated into UniProtKB/TrEMBL: December 16, 2008
Last sequence update: December 16, 2008
Last modified: May 23, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health