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Protein

Kunitz-type serine protease inhibitor TCI

Gene
N/A
Organism
Ophiophagus hannah (King cobra) (Naja hannah)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Serine protease inhibitor that strongly inhibits chymotrypsin (Ki=84.6 nM) and trypsin (Ki=391 nM).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei41 – 42Reactive bond for trypsinBy similarity2

GO - Molecular functioni

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI02.055.

Names & Taxonomyi

Protein namesi
Recommended name:
Kunitz-type serine protease inhibitor TCI
Alternative name(s):
Trypsin and chymotrypsin bi-functional serine protease inhibitor
Short name:
OH-TCI
OrganismiOphiophagus hannah (King cobra) (Naja hannah)
Taxonomic identifieri8665 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaElapidaeElapinaeOphiophagus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 251 PublicationAdd BLAST25
ChainiPRO_000037747326 – 83Kunitz-type serine protease inhibitor TCIAdd BLAST58

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi31 ↔ 81PROSITE-ProRule annotation
Disulfide bondi40 ↔ 64PROSITE-ProRule annotation
Disulfide bondi56 ↔ 77PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

TopDownProteomicsiB6RLX2.

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

3D structure databases

SMRiB6RLX2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 81BPTI/Kunitz inhibitorPROSITE-ProRule annotationAdd BLAST51

Sequence similaritiesi

Belongs to the venom Kunitz-type family.Curated

Keywords - Domaini

Signal

Family and domain databases

CDDicd00109. KU. 1 hit.
Gene3Di4.10.410.10. 1 hit.
InterProiView protein in InterPro
IPR002223. Kunitz_BPTI.
IPR036880. Kunitz_BPTI_sf.
IPR020901. Prtase_inh_Kunz-CS.
PfamiView protein in Pfam
PF00014. Kunitz_BPTI. 1 hit.
PRINTSiPR00759. BASICPTASE.
SMARTiView protein in SMART
SM00131. KU. 1 hit.
SUPFAMiSSF57362. SSF57362. 1 hit.
PROSITEiView protein in PROSITE
PS00280. BPTI_KUNITZ_1. 1 hit.
PS50279. BPTI_KUNITZ_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B6RLX2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSGRLLLLL GLLTLWAELT PVSGLGRPKF CELPAVSGFC KAYIPSFYYN
60 70 80
PDASACQKFI YGGCGGNANK FKTIEECHRT CVG
Length:83
Mass (Da):8,983
Last modified:December 16, 2008 - v1
Checksum:iBB14890B90D31BDC
GO

Mass spectrometryi

Molecular mass is 6339 Da from positions 25 - 83. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU246692 mRNA. Translation: ABY74980.1.

Similar proteinsi

Entry informationi

Entry nameiVKTCT_OPHHA
AccessioniPrimary (citable) accession number: B6RLX2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: December 16, 2008
Last modified: October 25, 2017
This is version 31 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families