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B6QVW4 (DAPB_PENMQ) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable dipeptidyl-aminopeptidase B

Short name=DPAP B
EC=3.4.14.5
Gene names
Name:dapB
ORF Names:PMAA_013400
OrganismPenicillium marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333) [Complete proteome]
Taxonomic identifier441960 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesTrichocomaceaeTalaromyces

Protein attributes

Sequence length899 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline By similarity.

Catalytic activity

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Subcellular location

Vacuole membrane; Single-pass type II membrane protein By similarity. Note: Lysosome-like vacuoles By similarity.

Sequence similarities

Belongs to the peptidase S9B family.

Ontologies

Keywords
   Cellular componentMembrane
Vacuole
   DomainSignal-anchor
Transmembrane
Transmembrane helix
   Molecular functionAminopeptidase
Hydrolase
Protease
Serine protease
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processproteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

vacuolar membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionaminopeptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

serine-type peptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 899899Probable dipeptidyl-aminopeptidase B
PRO_0000412157

Regions

Topological domain1 – 9191Cytoplasmic Potential
Transmembrane92 – 11221Helical; Signal-anchor for type II membrane protein; Potential
Topological domain113 – 899787Vacuolar Potential

Sites

Active site7521Charge relay system By similarity
Active site8291Charge relay system By similarity
Active site8621Charge relay system By similarity

Amino acid modifications

Glycosylation1491N-linked (GlcNAc...) Potential
Glycosylation1941N-linked (GlcNAc...) Potential
Glycosylation3471N-linked (GlcNAc...) Potential
Glycosylation4091N-linked (GlcNAc...) Potential
Glycosylation5131N-linked (GlcNAc...) Potential
Glycosylation6381N-linked (GlcNAc...) Potential
Glycosylation6431N-linked (GlcNAc...) Potential
Glycosylation8111N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
B6QVW4 [UniParc].

Last modified December 16, 2008. Version 1.
Checksum: D2920B066695CD62

FASTA899100,866
        10         20         30         40         50         60 
MARKDKDNGP EFVPLTNRSH RSSASFSSTD SLSSDGSLFG DDDVNALHSQ KITRTQLPEE 

        70         80         90        100        110        120 
NPYRDDDVEL ERGDNIFSRP TENSKRNRGS RLIWVVGLLC LGGWILAFVL FWGRRNSELS 

       130        140        150        160        170        180 
SSIAAVHGAD SATGSTSYGK PLTLDGVLNG SWGRRRHSIS WVAGPNGQDG LLLERDEDEK 

       190        200        210        220        230        240 
KAYLRVESIH SRQNQTDARE GWVLMESGAF AVNGKSLQPS ATWPSPDFKS VLVAANAVSN 

       250        260        270        280        290        300 
WRHSFTATYW LFDVDTQTAQ PLDPDEPKGR IQLASWSPQS DAVVFTRDNN LYLRKLDSDK 

       310        320        330        340        350        360 
VSQLTKDGGK DVFNGVPDWV YEEEVFGTDS TTWWSKDGKY VAFLRTNESM VPEFPIEYYM 

       370        380        390        400        410        420 
SRPSGKKPPA GLDKYPDVRK IKYPKAGSPN PVVTLQFYDI ENAEVFSVNV SGGFADDDRL 

       430        440        450        460        470        480 
ITEVVWASSG KVLVKEFNRE SDVIRTVLID VPSRTGELVR VDNFAQDDGG WAEVTQSTTF 

       490        500        510        520        530        540 
IPADPANGRP DDGYIDIIVH DGYDHWGYFT PVNNSVPVLL TSGPWEVVDT EPAVDLANNI 

       550        560        570        580        590        600 
VYFVASKESP TQRHVYSVKL DGSDLQPLTD VTKAGYYDAS FSIGGGYVLL SYDGPRVPWQ 

       610        620        630        640        650        660 
KVINTPSNQN PFEEIIEQNE QLSKMIEKYA LPAEIYQNIT IDNVTLQVVE RRPPHFNPVK 

       670        680        690        700        710        720 
KYPVLFWLYG GPGSQSVDRR FSVDFQSYVA STLGYIVVTV DGRGTGHIGR AARTIVRGNL 

       730        740        750        760        770        780 
GYWEARDQIE TAKAWAKKPY VDKDHIAIWG WSYGGFMTLK TLEQDAGQTF QYGMAVSPVT 

       790        800        810        820        830        840 
DWRFYDSIYT ERYMHTPEHN PTGYEHSAIS NMTALQQNVR FLVMHGTADD NVHFQNTLSL 

       850        860        870        880        890 
IDKLDMAGVE NYDVHVYPDS DHSIYFHNAH KMVYDRLSSW LVTAFTDGWQ QGNSVLPVT 

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References

[1]"The genome sequence of Penicillium marneffei strain ATCC 18224."
Fedorova N.D., Joardar V.S., Maiti R., Schobel S., Amedeo P., Galens K., Inman J.M., White O.R., Whitty B.R., Wortman J.R., Nierman W.C.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 18224 / CBS 334.59 / QM 7333.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DS995906 Genomic DNA. Translation: EEA19077.1.
RefSeqXP_002153462.1. XM_002153426.1.

3D structure databases

ProteinModelPortalB6QVW4.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS09.006.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7030827.

Phylogenomic databases

OrthoDBEOG72VHFG.

Family and domain databases

Gene3D2.140.10.30. 1 hit.
InterProIPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDAPB_PENMQ
AccessionPrimary (citable) accession number: B6QVW4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: December 16, 2008
Last modified: April 16, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries