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B6QVW4

- DAPB_PENMQ

UniProt

B6QVW4 - DAPB_PENMQ

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Protein

Probable dipeptidyl-aminopeptidase B

Gene

dapB

Organism
Penicillium marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.By similarity

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei752 – 7521Charge relay systemBy similarity
Active sitei829 – 8291Charge relay systemBy similarity
Active sitei862 – 8621Charge relay systemBy similarity

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. serine-type peptidase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS09.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
Short name:
DPAP B
Gene namesi
Name:dapB
ORF Names:PMAA_013400
OrganismiPenicillium marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333)
Taxonomic identifieri441960 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesTrichocomaceaeTalaromyces
ProteomesiUP000001294: Unassembled WGS sequence

Subcellular locationi

Vacuole membrane By similarity; Single-pass type II membrane protein By similarity
Note: Lysosome-like vacuoles.By similarity

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. vacuole Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 899899Probable dipeptidyl-aminopeptidase BPRO_0000412157Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi149 – 1491N-linked (GlcNAc...)Sequence Analysis
Glycosylationi194 – 1941N-linked (GlcNAc...)Sequence Analysis
Glycosylationi347 – 3471N-linked (GlcNAc...)Sequence Analysis
Glycosylationi409 – 4091N-linked (GlcNAc...)Sequence Analysis
Glycosylationi513 – 5131N-linked (GlcNAc...)Sequence Analysis
Glycosylationi638 – 6381N-linked (GlcNAc...)Sequence Analysis
Glycosylationi643 – 6431N-linked (GlcNAc...)Sequence Analysis
Glycosylationi811 – 8111N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliB6QVW4.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 9191CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini113 – 899787VacuolarSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei92 – 11221Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiEOG72VHFG.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

B6QVW4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MARKDKDNGP EFVPLTNRSH RSSASFSSTD SLSSDGSLFG DDDVNALHSQ
60 70 80 90 100
KITRTQLPEE NPYRDDDVEL ERGDNIFSRP TENSKRNRGS RLIWVVGLLC
110 120 130 140 150
LGGWILAFVL FWGRRNSELS SSIAAVHGAD SATGSTSYGK PLTLDGVLNG
160 170 180 190 200
SWGRRRHSIS WVAGPNGQDG LLLERDEDEK KAYLRVESIH SRQNQTDARE
210 220 230 240 250
GWVLMESGAF AVNGKSLQPS ATWPSPDFKS VLVAANAVSN WRHSFTATYW
260 270 280 290 300
LFDVDTQTAQ PLDPDEPKGR IQLASWSPQS DAVVFTRDNN LYLRKLDSDK
310 320 330 340 350
VSQLTKDGGK DVFNGVPDWV YEEEVFGTDS TTWWSKDGKY VAFLRTNESM
360 370 380 390 400
VPEFPIEYYM SRPSGKKPPA GLDKYPDVRK IKYPKAGSPN PVVTLQFYDI
410 420 430 440 450
ENAEVFSVNV SGGFADDDRL ITEVVWASSG KVLVKEFNRE SDVIRTVLID
460 470 480 490 500
VPSRTGELVR VDNFAQDDGG WAEVTQSTTF IPADPANGRP DDGYIDIIVH
510 520 530 540 550
DGYDHWGYFT PVNNSVPVLL TSGPWEVVDT EPAVDLANNI VYFVASKESP
560 570 580 590 600
TQRHVYSVKL DGSDLQPLTD VTKAGYYDAS FSIGGGYVLL SYDGPRVPWQ
610 620 630 640 650
KVINTPSNQN PFEEIIEQNE QLSKMIEKYA LPAEIYQNIT IDNVTLQVVE
660 670 680 690 700
RRPPHFNPVK KYPVLFWLYG GPGSQSVDRR FSVDFQSYVA STLGYIVVTV
710 720 730 740 750
DGRGTGHIGR AARTIVRGNL GYWEARDQIE TAKAWAKKPY VDKDHIAIWG
760 770 780 790 800
WSYGGFMTLK TLEQDAGQTF QYGMAVSPVT DWRFYDSIYT ERYMHTPEHN
810 820 830 840 850
PTGYEHSAIS NMTALQQNVR FLVMHGTADD NVHFQNTLSL IDKLDMAGVE
860 870 880 890
NYDVHVYPDS DHSIYFHNAH KMVYDRLSSW LVTAFTDGWQ QGNSVLPVT
Length:899
Mass (Da):100,866
Last modified:December 16, 2008 - v1
Checksum:iD2920B066695CD62
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS995906 Genomic DNA. Translation: EEA19077.1.
RefSeqiXP_002153462.1. XM_002153426.1.

Genome annotation databases

GeneIDi7030827.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS995906 Genomic DNA. Translation: EEA19077.1 .
RefSeqi XP_002153462.1. XM_002153426.1.

3D structure databases

ProteinModelPortali B6QVW4.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S09.006.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 7030827.

Phylogenomic databases

OrthoDBi EOG72VHFG.

Family and domain databases

Gene3Di 2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view ]
Pfami PF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Penicillium marneffei strain ATCC 18224."
    Fedorova N.D., Joardar V.S., Maiti R., Schobel S., Amedeo P., Galens K., Inman J.M., White O.R., Whitty B.R., Wortman J.R., Nierman W.C.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 18224 / CBS 334.59 / QM 7333.

Entry informationi

Entry nameiDAPB_PENMQ
AccessioniPrimary (citable) accession number: B6QVW4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: December 16, 2008
Last modified: October 29, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3