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B6QVW4

- DAPB_PENMQ

UniProt

B6QVW4 - DAPB_PENMQ

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Protein

Probable dipeptidyl-aminopeptidase B

Gene
dapB, PMAA_013400
Organism
Penicillium marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline By similarity.

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei752 – 7521Charge relay system By similarity
Active sitei829 – 8291Charge relay system By similarity
Active sitei862 – 8621Charge relay system By similarity

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. serine-type peptidase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS09.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
Short name:
DPAP B
Gene namesi
Name:dapB
ORF Names:PMAA_013400
OrganismiPenicillium marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333)
Taxonomic identifieri441960 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesTrichocomaceaeTalaromyces
ProteomesiUP000001294: Unassembled WGS sequence

Subcellular locationi

Vacuole membrane; Single-pass type II membrane protein By similarity
Note: Lysosome-like vacuoles By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 9191Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei92 – 11221Helical; Signal-anchor for type II membrane protein; Reviewed predictionAdd
BLAST
Topological domaini113 – 899787Vacuolar Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. vacuolar membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 899899Probable dipeptidyl-aminopeptidase BPRO_0000412157Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi149 – 1491N-linked (GlcNAc...) Reviewed prediction
Glycosylationi194 – 1941N-linked (GlcNAc...) Reviewed prediction
Glycosylationi347 – 3471N-linked (GlcNAc...) Reviewed prediction
Glycosylationi409 – 4091N-linked (GlcNAc...) Reviewed prediction
Glycosylationi513 – 5131N-linked (GlcNAc...) Reviewed prediction
Glycosylationi638 – 6381N-linked (GlcNAc...) Reviewed prediction
Glycosylationi643 – 6431N-linked (GlcNAc...) Reviewed prediction
Glycosylationi811 – 8111N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliB6QVW4.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiEOG72VHFG.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

B6QVW4-1 [UniParc]FASTAAdd to Basket

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MARKDKDNGP EFVPLTNRSH RSSASFSSTD SLSSDGSLFG DDDVNALHSQ    50
KITRTQLPEE NPYRDDDVEL ERGDNIFSRP TENSKRNRGS RLIWVVGLLC 100
LGGWILAFVL FWGRRNSELS SSIAAVHGAD SATGSTSYGK PLTLDGVLNG 150
SWGRRRHSIS WVAGPNGQDG LLLERDEDEK KAYLRVESIH SRQNQTDARE 200
GWVLMESGAF AVNGKSLQPS ATWPSPDFKS VLVAANAVSN WRHSFTATYW 250
LFDVDTQTAQ PLDPDEPKGR IQLASWSPQS DAVVFTRDNN LYLRKLDSDK 300
VSQLTKDGGK DVFNGVPDWV YEEEVFGTDS TTWWSKDGKY VAFLRTNESM 350
VPEFPIEYYM SRPSGKKPPA GLDKYPDVRK IKYPKAGSPN PVVTLQFYDI 400
ENAEVFSVNV SGGFADDDRL ITEVVWASSG KVLVKEFNRE SDVIRTVLID 450
VPSRTGELVR VDNFAQDDGG WAEVTQSTTF IPADPANGRP DDGYIDIIVH 500
DGYDHWGYFT PVNNSVPVLL TSGPWEVVDT EPAVDLANNI VYFVASKESP 550
TQRHVYSVKL DGSDLQPLTD VTKAGYYDAS FSIGGGYVLL SYDGPRVPWQ 600
KVINTPSNQN PFEEIIEQNE QLSKMIEKYA LPAEIYQNIT IDNVTLQVVE 650
RRPPHFNPVK KYPVLFWLYG GPGSQSVDRR FSVDFQSYVA STLGYIVVTV 700
DGRGTGHIGR AARTIVRGNL GYWEARDQIE TAKAWAKKPY VDKDHIAIWG 750
WSYGGFMTLK TLEQDAGQTF QYGMAVSPVT DWRFYDSIYT ERYMHTPEHN 800
PTGYEHSAIS NMTALQQNVR FLVMHGTADD NVHFQNTLSL IDKLDMAGVE 850
NYDVHVYPDS DHSIYFHNAH KMVYDRLSSW LVTAFTDGWQ QGNSVLPVT 899
Length:899
Mass (Da):100,866
Last modified:December 16, 2008 - v1
Checksum:iD2920B066695CD62
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS995906 Genomic DNA. Translation: EEA19077.1.
RefSeqiXP_002153462.1. XM_002153426.1.

Genome annotation databases

GeneIDi7030827.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS995906 Genomic DNA. Translation: EEA19077.1 .
RefSeqi XP_002153462.1. XM_002153426.1.

3D structure databases

ProteinModelPortali B6QVW4.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S09.006.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 7030827.

Phylogenomic databases

OrthoDBi EOG72VHFG.

Family and domain databases

Gene3Di 2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view ]
Pfami PF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Penicillium marneffei strain ATCC 18224."
    Fedorova N.D., Joardar V.S., Maiti R., Schobel S., Amedeo P., Galens K., Inman J.M., White O.R., Whitty B.R., Wortman J.R., Nierman W.C.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 18224 / CBS 334.59 / QM 7333.

Entry informationi

Entry nameiDAPB_PENMQ
AccessioniPrimary (citable) accession number: B6QVW4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: December 16, 2008
Last modified: June 11, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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