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Protein

Probable dipeptidyl-aminopeptidase B

Gene

dapB

Organism
Talaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333) (Penicillium marneffei)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.By similarity

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei752Charge relay systemBy similarity1
Active sitei829Charge relay systemBy similarity1
Active sitei862Charge relay systemBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Protein family/group databases

ESTHERipenmq-dapb. DPP4N_Peptidase_S9.
MEROPSiS09.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
Short name:
DPAP B
Gene namesi
Name:dapB
ORF Names:PMAA_013400
OrganismiTalaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333) (Penicillium marneffei)
Taxonomic identifieri441960 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesTrichocomaceaeTalaromyces
Proteomesi
  • UP000001294 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:PMAA_013400.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 91CytoplasmicSequence analysisAdd BLAST91
Transmembranei92 – 112Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini113 – 899VacuolarSequence analysisAdd BLAST787

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004121571 – 899Probable dipeptidyl-aminopeptidase BAdd BLAST899

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi149N-linked (GlcNAc...)Sequence analysis1
Glycosylationi194N-linked (GlcNAc...)Sequence analysis1
Glycosylationi347N-linked (GlcNAc...)Sequence analysis1
Glycosylationi409N-linked (GlcNAc...)Sequence analysis1
Glycosylationi513N-linked (GlcNAc...)Sequence analysis1
Glycosylationi638N-linked (GlcNAc...)Sequence analysis1
Glycosylationi643N-linked (GlcNAc...)Sequence analysis1
Glycosylationi811N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi441960.XP_002153462.1.

Structurei

3D structure databases

ProteinModelPortaliB6QVW4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2100. Eukaryota.
COG1506. LUCA.
OrthoDBiEOG092C0PZJ.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B_N.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

B6QVW4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARKDKDNGP EFVPLTNRSH RSSASFSSTD SLSSDGSLFG DDDVNALHSQ
60 70 80 90 100
KITRTQLPEE NPYRDDDVEL ERGDNIFSRP TENSKRNRGS RLIWVVGLLC
110 120 130 140 150
LGGWILAFVL FWGRRNSELS SSIAAVHGAD SATGSTSYGK PLTLDGVLNG
160 170 180 190 200
SWGRRRHSIS WVAGPNGQDG LLLERDEDEK KAYLRVESIH SRQNQTDARE
210 220 230 240 250
GWVLMESGAF AVNGKSLQPS ATWPSPDFKS VLVAANAVSN WRHSFTATYW
260 270 280 290 300
LFDVDTQTAQ PLDPDEPKGR IQLASWSPQS DAVVFTRDNN LYLRKLDSDK
310 320 330 340 350
VSQLTKDGGK DVFNGVPDWV YEEEVFGTDS TTWWSKDGKY VAFLRTNESM
360 370 380 390 400
VPEFPIEYYM SRPSGKKPPA GLDKYPDVRK IKYPKAGSPN PVVTLQFYDI
410 420 430 440 450
ENAEVFSVNV SGGFADDDRL ITEVVWASSG KVLVKEFNRE SDVIRTVLID
460 470 480 490 500
VPSRTGELVR VDNFAQDDGG WAEVTQSTTF IPADPANGRP DDGYIDIIVH
510 520 530 540 550
DGYDHWGYFT PVNNSVPVLL TSGPWEVVDT EPAVDLANNI VYFVASKESP
560 570 580 590 600
TQRHVYSVKL DGSDLQPLTD VTKAGYYDAS FSIGGGYVLL SYDGPRVPWQ
610 620 630 640 650
KVINTPSNQN PFEEIIEQNE QLSKMIEKYA LPAEIYQNIT IDNVTLQVVE
660 670 680 690 700
RRPPHFNPVK KYPVLFWLYG GPGSQSVDRR FSVDFQSYVA STLGYIVVTV
710 720 730 740 750
DGRGTGHIGR AARTIVRGNL GYWEARDQIE TAKAWAKKPY VDKDHIAIWG
760 770 780 790 800
WSYGGFMTLK TLEQDAGQTF QYGMAVSPVT DWRFYDSIYT ERYMHTPEHN
810 820 830 840 850
PTGYEHSAIS NMTALQQNVR FLVMHGTADD NVHFQNTLSL IDKLDMAGVE
860 870 880 890
NYDVHVYPDS DHSIYFHNAH KMVYDRLSSW LVTAFTDGWQ QGNSVLPVT
Length:899
Mass (Da):100,866
Last modified:December 16, 2008 - v1
Checksum:iD2920B066695CD62
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS995906 Genomic DNA. Translation: EEA19077.1.
RefSeqiXP_002153462.1. XM_002153426.1.

Genome annotation databases

EnsemblFungiiEEA19077; EEA19077; PMAA_013400.
GeneIDi7030827.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS995906 Genomic DNA. Translation: EEA19077.1.
RefSeqiXP_002153462.1. XM_002153426.1.

3D structure databases

ProteinModelPortaliB6QVW4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi441960.XP_002153462.1.

Protein family/group databases

ESTHERipenmq-dapb. DPP4N_Peptidase_S9.
MEROPSiS09.006.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEEA19077; EEA19077; PMAA_013400.
GeneIDi7030827.

Organism-specific databases

EuPathDBiFungiDB:PMAA_013400.

Phylogenomic databases

eggNOGiKOG2100. Eukaryota.
COG1506. LUCA.
OrthoDBiEOG092C0PZJ.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B_N.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDAPB_TALMQ
AccessioniPrimary (citable) accession number: B6QVW4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: December 16, 2008
Last modified: September 7, 2016
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.