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Protein

Pheromone-processing carboxypeptidase kex1

Gene

kex1

Organism
Talaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333) (Penicillium marneffei)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei170PROSITE-ProRule annotation1
Active sitei370PROSITE-ProRule annotation1
Active sitei432PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

MEROPSiS10.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase kex1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:kex1
ORF Names:PMAA_045500
OrganismiTalaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333) (Penicillium marneffei)
Taxonomic identifieri441960 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesTrichocomaceaeTalaromyces
Proteomesi
  • UP000001294 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:PMAA_045500.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 504LumenalSequence analysisAdd BLAST486
Transmembranei505 – 525HelicalSequence analysisAdd BLAST21
Topological domaini526 – 626CytoplasmicSequence analysisAdd BLAST101

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000041193419 – 626Pheromone-processing carboxypeptidase kex1Add BLAST608

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi106N-linked (GlcNAc...)Sequence analysis1
Glycosylationi421N-linked (GlcNAc...)Sequence analysis1
Glycosylationi429N-linked (GlcNAc...)Sequence analysis1
Glycosylationi478N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi441960.XP_002151727.1.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1282. Eukaryota.
COG2939. LUCA.
OrthoDBiEOG092C255X.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Ser_caboxypep_ser_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B6QQZ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGKALLLLL SSPICAWAQS AADYYVKSIP GQPDGPLLKM HAGHVEVDAE
60 70 80 90 100
TNGHLFFWHF QNRHIANRQR TILWLNGGPG CSSMDGALME IGPYRVKDDH
110 120 130 140 150
TLIYNNGSWD EFANLLFVDQ PVGTGFSYVN TNSYLHDLDH VAAHMITFLE
160 170 180 190 200
KWFAMFPEYE SDDLYIAGES YAGQYIPHIA RAIVERNKNI QRNQQHWPIK
210 220 230 240 250
GLLIGNGWIS PRDQYPANLQ YAYAEGIVKE GTAIANELDG IEKSCDEQLN
260 270 280 290 300
APGAGDLVDI RQCESILNKL LDLTRTSDDQ CINVYDIRLK DATCGNAWPP
310 320 330 340 350
DLDQMTDYLR RADVGAALNL DNGKANGWTE CNNQVTANFR MGHNGVPSIQ
360 370 380 390 400
LLPGLIESGV KVLLFSGDRD LICNHLGTES LIHNMKWSGG TGFETKPGVW
410 420 430 440 450
APRRGWTFEG EAAGYYQQAR NLTYVLFYNA SHMVPYDFPR RTRDMVDRFI
460 470 480 490 500
NVDIANIGGP PADSRLDGEK LPQTSVGNTT SSTSGTDQVD EAKLKDAEWK
510 520 530 540 550
AYTKSGEAAL IVVIIGVSVW GFFIWRARQR AARDGTSPTK KGYRAVYQDG
560 570 580 590 600
VDNNSSTDGA GLLSRFRNQS NSNSSRDLEA RDFDEAELDS LTPNLQNGHE
610 620
RDHYVIGEED EDEDNDIGNG AKSSLH
Length:626
Mass (Da):69,623
Last modified:December 16, 2008 - v1
Checksum:iC2B374719456DD9E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS995904 Genomic DNA. Translation: EEA20727.1.
RefSeqiXP_002151727.1. XM_002151691.1.

Genome annotation databases

EnsemblFungiiEEA20727; EEA20727; PMAA_045500.
GeneIDi7029168.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS995904 Genomic DNA. Translation: EEA20727.1.
RefSeqiXP_002151727.1. XM_002151691.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi441960.XP_002151727.1.

Protein family/group databases

MEROPSiS10.007.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEEA20727; EEA20727; PMAA_045500.
GeneIDi7029168.

Organism-specific databases

EuPathDBiFungiDB:PMAA_045500.

Phylogenomic databases

eggNOGiKOG1282. Eukaryota.
COG2939. LUCA.
OrthoDBiEOG092C255X.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Ser_caboxypep_ser_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKEX1_TALMQ
AccessioniPrimary (citable) accession number: B6QQZ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: December 16, 2008
Last modified: September 7, 2016
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.