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Protein

Pheromone-processing carboxypeptidase kex1

Gene

kex1

Organism
Penicillium marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei170 – 1701PROSITE-ProRule annotation
Active sitei370 – 3701PROSITE-ProRule annotation
Active sitei432 – 4321PROSITE-ProRule annotation

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase kex1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:kex1
ORF Names:PMAA_045500
OrganismiPenicillium marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333)
Taxonomic identifieri441960 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesTrichocomaceaeTalaromyces
ProteomesiUP000001294 Componenti: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 504486LumenalSequence AnalysisAdd
BLAST
Transmembranei505 – 52521HelicalSequence AnalysisAdd
BLAST
Topological domaini526 – 626101CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 626608Pheromone-processing carboxypeptidase kex1PRO_0000411934Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi106 – 1061N-linked (GlcNAc...)Sequence Analysis
Glycosylationi421 – 4211N-linked (GlcNAc...)Sequence Analysis
Glycosylationi429 – 4291N-linked (GlcNAc...)Sequence Analysis
Glycosylationi478 – 4781N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiEOG7TJ3SJ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B6QQZ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGKALLLLL SSPICAWAQS AADYYVKSIP GQPDGPLLKM HAGHVEVDAE
60 70 80 90 100
TNGHLFFWHF QNRHIANRQR TILWLNGGPG CSSMDGALME IGPYRVKDDH
110 120 130 140 150
TLIYNNGSWD EFANLLFVDQ PVGTGFSYVN TNSYLHDLDH VAAHMITFLE
160 170 180 190 200
KWFAMFPEYE SDDLYIAGES YAGQYIPHIA RAIVERNKNI QRNQQHWPIK
210 220 230 240 250
GLLIGNGWIS PRDQYPANLQ YAYAEGIVKE GTAIANELDG IEKSCDEQLN
260 270 280 290 300
APGAGDLVDI RQCESILNKL LDLTRTSDDQ CINVYDIRLK DATCGNAWPP
310 320 330 340 350
DLDQMTDYLR RADVGAALNL DNGKANGWTE CNNQVTANFR MGHNGVPSIQ
360 370 380 390 400
LLPGLIESGV KVLLFSGDRD LICNHLGTES LIHNMKWSGG TGFETKPGVW
410 420 430 440 450
APRRGWTFEG EAAGYYQQAR NLTYVLFYNA SHMVPYDFPR RTRDMVDRFI
460 470 480 490 500
NVDIANIGGP PADSRLDGEK LPQTSVGNTT SSTSGTDQVD EAKLKDAEWK
510 520 530 540 550
AYTKSGEAAL IVVIIGVSVW GFFIWRARQR AARDGTSPTK KGYRAVYQDG
560 570 580 590 600
VDNNSSTDGA GLLSRFRNQS NSNSSRDLEA RDFDEAELDS LTPNLQNGHE
610 620
RDHYVIGEED EDEDNDIGNG AKSSLH
Length:626
Mass (Da):69,623
Last modified:December 15, 2008 - v1
Checksum:iC2B374719456DD9E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS995904 Genomic DNA. Translation: EEA20727.1.
RefSeqiXP_002151727.1. XM_002151691.1.

Genome annotation databases

GeneIDi7029168.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS995904 Genomic DNA. Translation: EEA20727.1.
RefSeqiXP_002151727.1. XM_002151691.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi7029168.

Phylogenomic databases

OrthoDBiEOG7TJ3SJ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Penicillium marneffei strain ATCC 18224."
    Fedorova N.D., Joardar V.S., Maiti R., Schobel S., Amedeo P., Galens K., Inman J.M., White O.R., Whitty B.R., Wortman J.R., Nierman W.C.
    Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 18224 / CBS 334.59 / QM 7333.

Entry informationi

Entry nameiKEX1_PENMQ
AccessioniPrimary (citable) accession number: B6QQZ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 26, 2011
Last sequence update: December 15, 2008
Last modified: March 3, 2015
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.