B6QP49 (MTLD_PENMQ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mannitol-1-phosphate 5-dehydrogenase
Short name=M1PDH
Short name=MPD
Short name=MPDH
EC=1.1.1.17

Gene names

ORF Names:

PMAA_048060

Organism

Penicillium marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333) [Complete proteome]

Taxonomic identifier

441960 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Penicillium

Protein attributes

Sequence length	389 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the NAD(H)-dependent interconversion of D-fructose 6-phosphate and D-mannitol 1-phosphate in the mannitol metabolic pathway By similarity.
Catalytic activity	D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH.
Subunit structure	Monomer By similarity.
Sequence similarities	Belongs to the mannitol dehydrogenase family.
Sequence caution	The sequence EEA21000.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro mannitol-1-phosphate 5-dehydrogenase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 389	389	Mannitol-1-phosphate 5-dehydrogenase		PRO_0000371533
Regions
	Nucleotide binding	5 – 16	12	NAD By similarity
Sites
	Active site	214	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	B6QP49 [UniParc]. Last modified May 5, 2009. Version 2. Checksum: A305A10CEFB3693E	FASTA	389	43,188
	10 20 30 40 50 60 MGKKAIQFGG GNIGRGFVAE FLHESGYEVV FIDVVPQVIE SLNKNKSYEV TEISEEGEKT 70 80 90 100 110 120 KTITNYRALS SKTQEPEVVK EIATADVVTC AVGPNILKFI APVIAKGIDA REEGLPPIAV 130 140 150 160 170 180 IACENAINAT DALRGYIEEH LDKSRLDTLP KRARFANSAI DRIVPTQPEH AGLNVRIEKF 190 200 210 220 230 240 YEWAVEQTPF GEYGHPDISA IHWVDHLEPY IERKLFTVNT GHATAAYYGY KAGKKTIHEA 250 260 270 280 290 300 MAEETIHKAV HAALDETASL IISKHEITEQ EQKEYVKTII SRISNPYLED VVERVGRAPL 310 320 330 340 350 360 RKLSRKERFI GPAAQLAERG MKFDALLGSI EKALQFQNVK GDDESTELAK ILSEKTAAEA 370 380 TQQITGLETD HPLYQPVLKV VEKVQSVSK

References

[1]

"The genome sequence of Penicillium marneffei strain ATCC 18224." Fedorova N.D., Joardar V.S., Maiti R., Schobel S., Amedeo P., Galens K., Inman J.M., White O.R., Whitty B.R., Wortman J.R., Nierman W.C. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 18224 / CBS 334.59 / QM 7333.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DS995904 Genomic DNA. Translation: EEA21000.1. Sequence problems.
RefSeq	XP_002152000.1. XM_002151964.1.
3D structure databases
ProteinModelPortal	B6QP49.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7029423.
Family and domain databases
InterPro	IPR008927. 6-PGluconate_DH_C-like. IPR013328. DH_multihelical. IPR023028. Mannitol_1_phos_5_DH. IPR000669. Mannitol_DH. IPR013118. Mannitol_DH_C. IPR013131. Mannitol_DH_N. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
PRINTS	PR00084. MTLDHDRGNASE.
SUPFAM	SSF48179. 6DGDH_C_like. 1 hit.
PROSITE	PS00974. MANNITOL_DHGENASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MTLD_PENMQ

Accession

Primary (citable) accession number: B6QP49

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 5, 2009
Last sequence update:	May 5, 2009
Last modified:	December 14, 2011
This is version 19 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program