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B6QLF0 (BGALB_PENMQ) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable beta-galactosidase B

EC=3.2.1.23
Alternative name(s):
Lactase B
Gene names
Name:lacB
ORF Names:PMAA_057160
OrganismPenicillium marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333) [Complete proteome]
Taxonomic identifier441960 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesTrichocomaceaeTalaromyces

Protein attributes

Sequence length1009 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans By similarity.

Catalytic activity

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the glycosyl hydrolase 35 family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Polysaccharide degradation
   Cellular componentSecreted
   DomainSignal
   Molecular functionGlycosidase
Hydrolase
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processpolysaccharide catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionbeta-galactosidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 1009988Probable beta-galactosidase B
PRO_0000395231

Sites

Active site1911Proton donor Potential
Active site3031Nucleophile Potential
Binding site851Substrate By similarity
Binding site1301Substrate By similarity
Binding site1311Substrate; via amide nitrogen By similarity
Binding site1321Substrate By similarity
Binding site1901Substrate By similarity
Binding site2601Substrate By similarity
Binding site3681Substrate By similarity

Amino acid modifications

Glycosylation281N-linked (GlcNAc...) Potential
Glycosylation951N-linked (GlcNAc...) Potential
Glycosylation2471N-linked (GlcNAc...) Potential
Glycosylation3751N-linked (GlcNAc...) Potential
Glycosylation4061N-linked (GlcNAc...) Potential
Glycosylation4271N-linked (GlcNAc...) Potential
Glycosylation4511N-linked (GlcNAc...) Potential
Glycosylation6821N-linked (GlcNAc...) Potential
Glycosylation7401N-linked (GlcNAc...) Potential
Glycosylation7711N-linked (GlcNAc...) Potential
Glycosylation7841N-linked (GlcNAc...) Potential
Glycosylation8261N-linked (GlcNAc...) Potential
Glycosylation8831N-linked (GlcNAc...) Potential
Disulfide bond266 ↔ 319 By similarity

Sequences

Sequence LengthMass (Da)Tools
B6QLF0 [UniParc].

Last modified December 16, 2008. Version 1.
Checksum: CCE39753CD678910

FASTA1,009111,835
        10         20         30         40         50         60 
MAQLFTKIIV YFLLFASPLL ANQWPLHNNS LNDVVQWDHY SFEINGQRLF VFAGEWHYWR 

        70         80         90        100        110        120 
IPVPELWIDI LEKIKAAGFT AFGIYVNWAY HAPNNYTVDF ATGAHDITPI LKMAKDVGLY 

       130        140        150        160        170        180 
VLLRPGPYIN AEVNAGGFPL WVTTGEYGSL RNDDSRYTAA WEPYFTKISE IASEYQITKG 

       190        200        210        220        230        240 
GNVVTYQIEN EFGDQWTGSP SRRVQYEPAA KYMELLEANA RRNGIDIPLV ANEPNMRAIS 

       250        260        270        280        290        300 
WGKDWSNSSA NVDVVGLDSY PSCWTCDLSV CTGTTGEYIA YQVIDYYGYF QETQPTMPSF 

       310        320        330        340        350        360 
FAEFQGGSYN PWGGPVGGCP EDIGPDFANL FYRWNIGQRV TAINLYMLYG GTNWGAIAAP 

       370        380        390        400        410        420 
VVASSYDYSS PISENRTIGA KYYETKLLTM FTRAARDLIV TDLIGNGTQY STNPAIQTHV 

       430        440        450        460        470        480 
IRNPITNGTF YVTLHTISSS STDETFQLHV NTSAGAFSIP RYGNSIRLNG HQSKIIVTDF 

       490        500        510        520        530        540 
QFGTHKLLYS TAEVLTYTVL DGIPTLALWV PTGESGEFSV LGGKWASVLR CEWCSDIQFH 

       550        560        570        580        590        600 
PEQDQTSNPT VSRLTVSFTQ GQGMSVIKLD TGLRVVLLDR ESAYYFWAPA LNSDPSVPED 

       610        620        630        640        650        660 
QSVLVQGPHL VRSAKIVGST IRLTGDSAQT SPIEVFAPKQ VRIIFWNDKE LKTSKTSYDS 

       670        680        690        700        710        720 
LQASLPQPAY VKLPLLGPWK YNGSLPEKAQ DYKDTSAAWI SADHMKTSNP SPPATFPVLY 

       730        740        750        760        770        780 
ADEYGFHNSI RIWRGYFTGN ATGVVLKVQG GYAFGFSGWL NGKLLGSYLG NASVEHSHLT 

       790        800        810        820        830        840 
LPFNVSHVST SSDNVLVIVH DDTGHDETTG ALNPRGILEA TLLSDNSSSK FSHWRVAGTA 

       850        860        870        880        890        900 
GGETNIDPMR GPYNEGGLYA ERMGWHLPGF NDNAWSDAGS KLNFTGADIK FYRTTVPLNI 

       910        920        930        940        950        960 
PKGVDVSISF ELSACGTTNA FRSQLFVNGY QMGRFNPWVG NQIEFPVPPG ILDYTGDNTI 

       970        980        990       1000 
GLSLWAQTED GACAIVDWKI NYVLGSSLDV TFNGEYLRPG WTSERLQYS 

« Hide

References

[1]"The genome sequence of Penicillium marneffei strain ATCC 18224."
Fedorova N.D., Joardar V.S., Maiti R., Schobel S., Amedeo P., Galens K., Inman J.M., White O.R., Whitty B.R., Wortman J.R., Nierman W.C.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 18224 / CBS 334.59 / QM 7333.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DS995903 Genomic DNA. Translation: EEA21927.1.
RefSeqXP_002150536.1. XM_002150500.1.

3D structure databases

ProteinModelPortalB6QLF0.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7028036.

Phylogenomic databases

OrthoDBEOG7ZGXBD.

Family and domain databases

Gene3D2.102.20.10. 1 hit.
2.60.120.260. 2 hits.
2.60.390.10. 1 hit.
3.20.20.80. 1 hit.
InterProIPR018954. Betagal_dom2.
IPR025972. BetaGal_dom3.
IPR025300. BetaGal_jelly_roll_dom.
IPR008979. Galactose-bd-like.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERPTHR23421. PTHR23421. 1 hit.
PfamPF10435. BetaGal_dom2. 1 hit.
PF13363. BetaGal_dom3. 1 hit.
PF13364. BetaGal_dom4_5. 2 hits.
PF01301. Glyco_hydro_35. 1 hit.
[Graphical view]
PRINTSPR00742. GLHYDRLASE35.
SUPFAMSSF117100. SSF117100. 1 hit.
SSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.
ProtoNetSearch...

Entry information

Entry nameBGALB_PENMQ
AccessionPrimary (citable) accession number: B6QLF0
Entry history
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: December 16, 2008
Last modified: April 16, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries