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B6QLF0

- BGALB_PENMQ

UniProt

B6QLF0 - BGALB_PENMQ

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Protein
Probable beta-galactosidase B
Gene
lacB, PMAA_057160
Organism
Penicillium marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans By similarity.

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei85 – 851Substrate By similarity
Binding sitei130 – 1301Substrate By similarity
Binding sitei131 – 1311Substrate; via amide nitrogen By similarity
Binding sitei132 – 1321Substrate By similarity
Binding sitei190 – 1901Substrate By similarity
Active sitei191 – 1911Proton donor Reviewed prediction
Binding sitei260 – 2601Substrate By similarity
Active sitei303 – 3031Nucleophile Reviewed prediction
Binding sitei368 – 3681Substrate By similarity

GO - Molecular functioni

  1. beta-galactosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. polysaccharide catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Polysaccharide degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable beta-galactosidase B (EC:3.2.1.23)
Alternative name(s):
Lactase B
Gene namesi
Name:lacB
ORF Names:PMAA_057160
OrganismiPenicillium marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333)
Taxonomic identifieri441960 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesTrichocomaceaeTalaromyces
ProteomesiUP000001294: Unassembled WGS sequence

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed prediction
Add
BLAST
Chaini22 – 1009988Probable beta-galactosidase B
PRO_0000395231Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi28 – 281N-linked (GlcNAc...) Reviewed prediction
Glycosylationi95 – 951N-linked (GlcNAc...) Reviewed prediction
Glycosylationi247 – 2471N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi266 ↔ 319 By similarity
Glycosylationi375 – 3751N-linked (GlcNAc...) Reviewed prediction
Glycosylationi406 – 4061N-linked (GlcNAc...) Reviewed prediction
Glycosylationi427 – 4271N-linked (GlcNAc...) Reviewed prediction
Glycosylationi451 – 4511N-linked (GlcNAc...) Reviewed prediction
Glycosylationi682 – 6821N-linked (GlcNAc...) Reviewed prediction
Glycosylationi740 – 7401N-linked (GlcNAc...) Reviewed prediction
Glycosylationi771 – 7711N-linked (GlcNAc...) Reviewed prediction
Glycosylationi784 – 7841N-linked (GlcNAc...) Reviewed prediction
Glycosylationi826 – 8261N-linked (GlcNAc...) Reviewed prediction
Glycosylationi883 – 8831N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliB6QLF0.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

OrthoDBiEOG7ZGXBD.

Family and domain databases

Gene3Di2.102.20.10. 1 hit.
2.60.120.260. 2 hits.
2.60.390.10. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR018954. Betagal_dom2.
IPR025972. BetaGal_dom3.
IPR025300. BetaGal_jelly_roll_dom.
IPR008979. Galactose-bd-like.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR23421. PTHR23421. 1 hit.
PfamiPF10435. BetaGal_dom2. 1 hit.
PF13363. BetaGal_dom3. 1 hit.
PF13364. BetaGal_dom4_5. 2 hits.
PF01301. Glyco_hydro_35. 1 hit.
[Graphical view]
PRINTSiPR00742. GLHYDRLASE35.
SUPFAMiSSF117100. SSF117100. 1 hit.
SSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B6QLF0-1 [UniParc]FASTAAdd to Basket

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MAQLFTKIIV YFLLFASPLL ANQWPLHNNS LNDVVQWDHY SFEINGQRLF     50
VFAGEWHYWR IPVPELWIDI LEKIKAAGFT AFGIYVNWAY HAPNNYTVDF 100
ATGAHDITPI LKMAKDVGLY VLLRPGPYIN AEVNAGGFPL WVTTGEYGSL 150
RNDDSRYTAA WEPYFTKISE IASEYQITKG GNVVTYQIEN EFGDQWTGSP 200
SRRVQYEPAA KYMELLEANA RRNGIDIPLV ANEPNMRAIS WGKDWSNSSA 250
NVDVVGLDSY PSCWTCDLSV CTGTTGEYIA YQVIDYYGYF QETQPTMPSF 300
FAEFQGGSYN PWGGPVGGCP EDIGPDFANL FYRWNIGQRV TAINLYMLYG 350
GTNWGAIAAP VVASSYDYSS PISENRTIGA KYYETKLLTM FTRAARDLIV 400
TDLIGNGTQY STNPAIQTHV IRNPITNGTF YVTLHTISSS STDETFQLHV 450
NTSAGAFSIP RYGNSIRLNG HQSKIIVTDF QFGTHKLLYS TAEVLTYTVL 500
DGIPTLALWV PTGESGEFSV LGGKWASVLR CEWCSDIQFH PEQDQTSNPT 550
VSRLTVSFTQ GQGMSVIKLD TGLRVVLLDR ESAYYFWAPA LNSDPSVPED 600
QSVLVQGPHL VRSAKIVGST IRLTGDSAQT SPIEVFAPKQ VRIIFWNDKE 650
LKTSKTSYDS LQASLPQPAY VKLPLLGPWK YNGSLPEKAQ DYKDTSAAWI 700
SADHMKTSNP SPPATFPVLY ADEYGFHNSI RIWRGYFTGN ATGVVLKVQG 750
GYAFGFSGWL NGKLLGSYLG NASVEHSHLT LPFNVSHVST SSDNVLVIVH 800
DDTGHDETTG ALNPRGILEA TLLSDNSSSK FSHWRVAGTA GGETNIDPMR 850
GPYNEGGLYA ERMGWHLPGF NDNAWSDAGS KLNFTGADIK FYRTTVPLNI 900
PKGVDVSISF ELSACGTTNA FRSQLFVNGY QMGRFNPWVG NQIEFPVPPG 950
ILDYTGDNTI GLSLWAQTED GACAIVDWKI NYVLGSSLDV TFNGEYLRPG 1000
WTSERLQYS 1009
Length:1,009
Mass (Da):111,835
Last modified:December 16, 2008 - v1
Checksum:iCCE39753CD678910
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS995903 Genomic DNA. Translation: EEA21927.1.
RefSeqiXP_002150536.1. XM_002150500.1.

Genome annotation databases

GeneIDi7028036.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS995903 Genomic DNA. Translation: EEA21927.1 .
RefSeqi XP_002150536.1. XM_002150500.1.

3D structure databases

ProteinModelPortali B6QLF0.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 7028036.

Phylogenomic databases

OrthoDBi EOG7ZGXBD.

Family and domain databases

Gene3Di 2.102.20.10. 1 hit.
2.60.120.260. 2 hits.
2.60.390.10. 1 hit.
3.20.20.80. 1 hit.
InterProi IPR018954. Betagal_dom2.
IPR025972. BetaGal_dom3.
IPR025300. BetaGal_jelly_roll_dom.
IPR008979. Galactose-bd-like.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR23421. PTHR23421. 1 hit.
Pfami PF10435. BetaGal_dom2. 1 hit.
PF13363. BetaGal_dom3. 1 hit.
PF13364. BetaGal_dom4_5. 2 hits.
PF01301. Glyco_hydro_35. 1 hit.
[Graphical view ]
PRINTSi PR00742. GLHYDRLASE35.
SUPFAMi SSF117100. SSF117100. 1 hit.
SSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Penicillium marneffei strain ATCC 18224."
    Fedorova N.D., Joardar V.S., Maiti R., Schobel S., Amedeo P., Galens K., Inman J.M., White O.R., Whitty B.R., Wortman J.R., Nierman W.C.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 18224 / CBS 334.59 / QM 7333.

Entry informationi

Entry nameiBGALB_PENMQ
AccessioniPrimary (citable) accession number: B6QLF0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: December 16, 2008
Last modified: April 16, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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