Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

B6QLF0

- BGALB_PENMQ

UniProt

B6QLF0 - BGALB_PENMQ

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Probable beta-galactosidase B

Gene

lacB

Organism
Penicillium marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.By similarity

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei85 – 851SubstrateBy similarity
Binding sitei130 – 1301SubstrateBy similarity
Binding sitei131 – 1311Substrate; via amide nitrogenBy similarity
Binding sitei132 – 1321SubstrateBy similarity
Binding sitei190 – 1901SubstrateBy similarity
Active sitei191 – 1911Proton donorSequence Analysis
Binding sitei260 – 2601SubstrateBy similarity
Active sitei303 – 3031NucleophileSequence Analysis
Binding sitei368 – 3681SubstrateBy similarity

GO - Molecular functioni

  1. beta-galactosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. polysaccharide catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Polysaccharide degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable beta-galactosidase B (EC:3.2.1.23)
Alternative name(s):
Lactase B
Gene namesi
Name:lacB
ORF Names:PMAA_057160
OrganismiPenicillium marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333)
Taxonomic identifieri441960 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesTrichocomaceaeTalaromyces
ProteomesiUP000001294: Unassembled WGS sequence

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 1009988Probable beta-galactosidase BPRO_0000395231Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi28 – 281N-linked (GlcNAc...)Sequence Analysis
Glycosylationi95 – 951N-linked (GlcNAc...)Sequence Analysis
Glycosylationi247 – 2471N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi266 ↔ 319By similarity
Glycosylationi375 – 3751N-linked (GlcNAc...)Sequence Analysis
Glycosylationi406 – 4061N-linked (GlcNAc...)Sequence Analysis
Glycosylationi427 – 4271N-linked (GlcNAc...)Sequence Analysis
Glycosylationi451 – 4511N-linked (GlcNAc...)Sequence Analysis
Glycosylationi682 – 6821N-linked (GlcNAc...)Sequence Analysis
Glycosylationi740 – 7401N-linked (GlcNAc...)Sequence Analysis
Glycosylationi771 – 7711N-linked (GlcNAc...)Sequence Analysis
Glycosylationi784 – 7841N-linked (GlcNAc...)Sequence Analysis
Glycosylationi826 – 8261N-linked (GlcNAc...)Sequence Analysis
Glycosylationi883 – 8831N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliB6QLF0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 35 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

OrthoDBiEOG7ZGXBD.

Family and domain databases

Gene3Di2.102.20.10. 1 hit.
2.60.120.260. 2 hits.
2.60.390.10. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR018954. Betagal_dom2.
IPR025972. BetaGal_dom3.
IPR025300. BetaGal_jelly_roll_dom.
IPR008979. Galactose-bd-like.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR23421. PTHR23421. 1 hit.
PfamiPF10435. BetaGal_dom2. 1 hit.
PF13363. BetaGal_dom3. 1 hit.
PF13364. BetaGal_dom4_5. 2 hits.
PF01301. Glyco_hydro_35. 1 hit.
[Graphical view]
PRINTSiPR00742. GLHYDRLASE35.
SUPFAMiSSF117100. SSF117100. 1 hit.
SSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B6QLF0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAQLFTKIIV YFLLFASPLL ANQWPLHNNS LNDVVQWDHY SFEINGQRLF
60 70 80 90 100
VFAGEWHYWR IPVPELWIDI LEKIKAAGFT AFGIYVNWAY HAPNNYTVDF
110 120 130 140 150
ATGAHDITPI LKMAKDVGLY VLLRPGPYIN AEVNAGGFPL WVTTGEYGSL
160 170 180 190 200
RNDDSRYTAA WEPYFTKISE IASEYQITKG GNVVTYQIEN EFGDQWTGSP
210 220 230 240 250
SRRVQYEPAA KYMELLEANA RRNGIDIPLV ANEPNMRAIS WGKDWSNSSA
260 270 280 290 300
NVDVVGLDSY PSCWTCDLSV CTGTTGEYIA YQVIDYYGYF QETQPTMPSF
310 320 330 340 350
FAEFQGGSYN PWGGPVGGCP EDIGPDFANL FYRWNIGQRV TAINLYMLYG
360 370 380 390 400
GTNWGAIAAP VVASSYDYSS PISENRTIGA KYYETKLLTM FTRAARDLIV
410 420 430 440 450
TDLIGNGTQY STNPAIQTHV IRNPITNGTF YVTLHTISSS STDETFQLHV
460 470 480 490 500
NTSAGAFSIP RYGNSIRLNG HQSKIIVTDF QFGTHKLLYS TAEVLTYTVL
510 520 530 540 550
DGIPTLALWV PTGESGEFSV LGGKWASVLR CEWCSDIQFH PEQDQTSNPT
560 570 580 590 600
VSRLTVSFTQ GQGMSVIKLD TGLRVVLLDR ESAYYFWAPA LNSDPSVPED
610 620 630 640 650
QSVLVQGPHL VRSAKIVGST IRLTGDSAQT SPIEVFAPKQ VRIIFWNDKE
660 670 680 690 700
LKTSKTSYDS LQASLPQPAY VKLPLLGPWK YNGSLPEKAQ DYKDTSAAWI
710 720 730 740 750
SADHMKTSNP SPPATFPVLY ADEYGFHNSI RIWRGYFTGN ATGVVLKVQG
760 770 780 790 800
GYAFGFSGWL NGKLLGSYLG NASVEHSHLT LPFNVSHVST SSDNVLVIVH
810 820 830 840 850
DDTGHDETTG ALNPRGILEA TLLSDNSSSK FSHWRVAGTA GGETNIDPMR
860 870 880 890 900
GPYNEGGLYA ERMGWHLPGF NDNAWSDAGS KLNFTGADIK FYRTTVPLNI
910 920 930 940 950
PKGVDVSISF ELSACGTTNA FRSQLFVNGY QMGRFNPWVG NQIEFPVPPG
960 970 980 990 1000
ILDYTGDNTI GLSLWAQTED GACAIVDWKI NYVLGSSLDV TFNGEYLRPG

WTSERLQYS
Length:1,009
Mass (Da):111,835
Last modified:December 16, 2008 - v1
Checksum:iCCE39753CD678910
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS995903 Genomic DNA. Translation: EEA21927.1.
RefSeqiXP_002150536.1. XM_002150500.1.

Genome annotation databases

GeneIDi7028036.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS995903 Genomic DNA. Translation: EEA21927.1 .
RefSeqi XP_002150536.1. XM_002150500.1.

3D structure databases

ProteinModelPortali B6QLF0.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 7028036.

Phylogenomic databases

OrthoDBi EOG7ZGXBD.

Family and domain databases

Gene3Di 2.102.20.10. 1 hit.
2.60.120.260. 2 hits.
2.60.390.10. 1 hit.
3.20.20.80. 1 hit.
InterProi IPR018954. Betagal_dom2.
IPR025972. BetaGal_dom3.
IPR025300. BetaGal_jelly_roll_dom.
IPR008979. Galactose-bd-like.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR23421. PTHR23421. 1 hit.
Pfami PF10435. BetaGal_dom2. 1 hit.
PF13363. BetaGal_dom3. 1 hit.
PF13364. BetaGal_dom4_5. 2 hits.
PF01301. Glyco_hydro_35. 1 hit.
[Graphical view ]
PRINTSi PR00742. GLHYDRLASE35.
SUPFAMi SSF117100. SSF117100. 1 hit.
SSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Penicillium marneffei strain ATCC 18224."
    Fedorova N.D., Joardar V.S., Maiti R., Schobel S., Amedeo P., Galens K., Inman J.M., White O.R., Whitty B.R., Wortman J.R., Nierman W.C.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 18224 / CBS 334.59 / QM 7333.

Entry informationi

Entry nameiBGALB_PENMQ
AccessioniPrimary (citable) accession number: B6QLF0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: December 16, 2008
Last modified: October 29, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3