Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

B6QHA9

- BGALC_PENMQ

UniProt

B6QHA9 - BGALC_PENMQ

Protein

Probable beta-galactosidase C

Gene

lacC

Organism
Penicillium marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 34 (01 Oct 2014)
      Sequence version 1 (16 Dec 2008)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.By similarity

    Catalytic activityi

    Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei80 – 801SubstrateBy similarity
    Binding sitei125 – 1251SubstrateBy similarity
    Binding sitei127 – 1271SubstrateBy similarity
    Binding sitei185 – 1851SubstrateBy similarity
    Active sitei186 – 1861Proton donorSequence Analysis
    Binding sitei249 – 2491SubstrateBy similarity
    Active sitei285 – 2851NucleophileSequence Analysis
    Binding sitei351 – 3511SubstrateBy similarity

    GO - Molecular functioni

    1. beta-galactosidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. polysaccharide catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Carbohydrate metabolism, Polysaccharide degradation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable beta-galactosidase C (EC:3.2.1.23)
    Alternative name(s):
    Lactase C
    Gene namesi
    Name:lacC
    ORF Names:PMAA_093700
    OrganismiPenicillium marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333)
    Taxonomic identifieri441960 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesTrichocomaceaeTalaromyces
    ProteomesiUP000001294: Unassembled WGS sequence

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 999978Probable beta-galactosidase CPRO_0000395240Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi25 – 251N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi195 – 1951N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi255 ↔ 302By similarity
    Glycosylationi274 – 2741N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi389 – 3891N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi441 – 4411N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi512 – 5121N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi519 – 5191N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi600 – 6001N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi675 – 6751N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi713 – 7131N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi757 – 7571N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi808 – 8081N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi897 – 8971N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliB6QHA9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 35 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    OrthoDBiEOG7ZGXBD.

    Family and domain databases

    Gene3Di2.102.20.10. 1 hit.
    2.60.120.260. 2 hits.
    2.60.390.10. 1 hit.
    3.20.20.80. 1 hit.
    InterProiIPR018954. Betagal_dom2.
    IPR025972. BetaGal_dom3.
    IPR025300. BetaGal_jelly_roll_dom.
    IPR008979. Galactose-bd-like.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR001944. Glycoside_Hdrlase_35.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PANTHERiPTHR23421. PTHR23421. 1 hit.
    PfamiPF10435. BetaGal_dom2. 1 hit.
    PF13363. BetaGal_dom3. 1 hit.
    PF13364. BetaGal_dom4_5. 2 hits.
    PF01301. Glyco_hydro_35. 1 hit.
    [Graphical view]
    PRINTSiPR00742. GLHYDRLASE35.
    SUPFAMiSSF117100. SSF117100. 1 hit.
    SSF49785. SSF49785. 2 hits.
    SSF51445. SSF51445. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    B6QHA9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFFFRFLTTV LLLFNAKLLV AQSSNTSSPV HWDKYSLSIN GERLFVFAGE    50
    FHYIRLPVPE LWLDVFQKLK ANGFNAISVY FYWNHHSASE GVYDFETGGH 100
    NVQRLFDYAK QAGVYIIARP GPYANGELSA GGYALWAANG RLGGERTRDS 150
    QYYDLWSPWM TKIGKIIAAN QITEGGPVIL VQHENELQET THRANNTLVL 200
    YMEQITQILD AAGIVVPSTH NEKGMRSMSW SMDYEDVGGA VNIYGLDSYP 250
    GGLSCTNPNA GFNLIRTYYQ WFQNYSYTQP EYLAEFQGGY FTPWGGVFYD 300
    DCASMLQPEY ADVFYKNNIG NRVTLQSLYM AYGGTNWGHI AAPVVYTSYD 350
    YSAPLRETRE IRDKLKQTKL LGLFTRVSPD LLQTEMEGNG TSYTTGANIF 400
    TWALRNPETN AGFYVVAQDD SSSTTDVVFD LEVETSAGSV NITNIGLDGR 450
    QSKIITTDYK VGDTTLLYCS ADILTYATLD VDVLALYLNK GQTGTFVLAN 500
    AASHLKYTVY GNSTVTSSNS SQGTIYTYTQ GQGISAIKFS NRFLVYLLDK 550
    YTAWDFFAPP LQLSDPNVKP NEHIFVIGPY LVREATIKGR TLELTGDNQN 600
    TTSIEIYHGN PFITSITWNG KHLSTKRTAY GSLTATIPGA EAITITLPKL 650
    TSWKSHDMIP EIDPEYDDSN WVVCNKTTSF NAIAPLSLPV LYSGDYGYHA 700
    GPKIYRGRFG STNATGVTVT AQNGNAAGWS AWLNGIYIGG VTGDPSIEAT 750
    SAVLKFNSST TLKQEGSENV LTVLVDYTGH DEDNVKPARA QNPRGLLGVI 800
    FEGSTSTNFT SWKLQGNAGG EKNIDALRGP MNEGGFYGER LGWHLPGFEP 850
    STKSGWDTRA PSDGVDGGSH RFYITEFTLD LGPNSHALDV PIGIHLNASS 900
    TSGPAVAYVW LNGYKFAHYL PHIGPQTVFP FQPGVLNIQG SEGHKRKNTL 950
    AVSLWALTDQ PAALDVVELV AYGKYTSSFD FARDWSYLQP RWVDRSKYA 999
    Length:999
    Mass (Da):110,430
    Last modified:December 16, 2008 - v1
    Checksum:iCD1A02A994EB2050
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS995902 Genomic DNA. Translation: EEA22754.1.
    RefSeqiXP_002148921.1. XM_002148885.1.

    Genome annotation databases

    GeneIDi7026488.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS995902 Genomic DNA. Translation: EEA22754.1 .
    RefSeqi XP_002148921.1. XM_002148885.1.

    3D structure databases

    ProteinModelPortali B6QHA9.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 7026488.

    Phylogenomic databases

    OrthoDBi EOG7ZGXBD.

    Family and domain databases

    Gene3Di 2.102.20.10. 1 hit.
    2.60.120.260. 2 hits.
    2.60.390.10. 1 hit.
    3.20.20.80. 1 hit.
    InterProi IPR018954. Betagal_dom2.
    IPR025972. BetaGal_dom3.
    IPR025300. BetaGal_jelly_roll_dom.
    IPR008979. Galactose-bd-like.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR001944. Glycoside_Hdrlase_35.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    PANTHERi PTHR23421. PTHR23421. 1 hit.
    Pfami PF10435. BetaGal_dom2. 1 hit.
    PF13363. BetaGal_dom3. 1 hit.
    PF13364. BetaGal_dom4_5. 2 hits.
    PF01301. Glyco_hydro_35. 1 hit.
    [Graphical view ]
    PRINTSi PR00742. GLHYDRLASE35.
    SUPFAMi SSF117100. SSF117100. 1 hit.
    SSF49785. SSF49785. 2 hits.
    SSF51445. SSF51445. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Penicillium marneffei strain ATCC 18224."
      Fedorova N.D., Joardar V.S., Maiti R., Schobel S., Amedeo P., Galens K., Inman J.M., White O.R., Whitty B.R., Wortman J.R., Nierman W.C.
      Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 18224 / CBS 334.59 / QM 7333.

    Entry informationi

    Entry nameiBGALC_PENMQ
    AccessioniPrimary (citable) accession number: B6QHA9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 13, 2010
    Last sequence update: December 16, 2008
    Last modified: October 1, 2014
    This is version 34 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3