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B6QHA9 (BGALC_PENMQ) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable beta-galactosidase C

EC=3.2.1.23
Alternative name(s):
Lactase C
Gene names
Name:lacC
ORF Names:PMAA_093700
OrganismPenicillium marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333) [Complete proteome]
Taxonomic identifier441960 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesTrichocomaceaeTalaromyces

Protein attributes

Sequence length999 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans By similarity.

Catalytic activity

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the glycosyl hydrolase 35 family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Polysaccharide degradation
   Cellular componentSecreted
   DomainSignal
   Molecular functionGlycosidase
Hydrolase
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processpolysaccharide catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionbeta-galactosidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 999978Probable beta-galactosidase C
PRO_0000395240

Sites

Active site1861Proton donor Potential
Active site2851Nucleophile Potential
Binding site801Substrate By similarity
Binding site1251Substrate By similarity
Binding site1271Substrate By similarity
Binding site1851Substrate By similarity
Binding site2491Substrate By similarity
Binding site3511Substrate By similarity

Amino acid modifications

Glycosylation251N-linked (GlcNAc...) Potential
Glycosylation1951N-linked (GlcNAc...) Potential
Glycosylation2741N-linked (GlcNAc...) Potential
Glycosylation3891N-linked (GlcNAc...) Potential
Glycosylation4411N-linked (GlcNAc...) Potential
Glycosylation5121N-linked (GlcNAc...) Potential
Glycosylation5191N-linked (GlcNAc...) Potential
Glycosylation6001N-linked (GlcNAc...) Potential
Glycosylation6751N-linked (GlcNAc...) Potential
Glycosylation7131N-linked (GlcNAc...) Potential
Glycosylation7571N-linked (GlcNAc...) Potential
Glycosylation8081N-linked (GlcNAc...) Potential
Glycosylation8971N-linked (GlcNAc...) Potential
Disulfide bond255 ↔ 302 By similarity

Sequences

Sequence LengthMass (Da)Tools
B6QHA9 [UniParc].

Last modified December 16, 2008. Version 1.
Checksum: CD1A02A994EB2050

FASTA999110,430
        10         20         30         40         50         60 
MFFFRFLTTV LLLFNAKLLV AQSSNTSSPV HWDKYSLSIN GERLFVFAGE FHYIRLPVPE 

        70         80         90        100        110        120 
LWLDVFQKLK ANGFNAISVY FYWNHHSASE GVYDFETGGH NVQRLFDYAK QAGVYIIARP 

       130        140        150        160        170        180 
GPYANGELSA GGYALWAANG RLGGERTRDS QYYDLWSPWM TKIGKIIAAN QITEGGPVIL 

       190        200        210        220        230        240 
VQHENELQET THRANNTLVL YMEQITQILD AAGIVVPSTH NEKGMRSMSW SMDYEDVGGA 

       250        260        270        280        290        300 
VNIYGLDSYP GGLSCTNPNA GFNLIRTYYQ WFQNYSYTQP EYLAEFQGGY FTPWGGVFYD 

       310        320        330        340        350        360 
DCASMLQPEY ADVFYKNNIG NRVTLQSLYM AYGGTNWGHI AAPVVYTSYD YSAPLRETRE 

       370        380        390        400        410        420 
IRDKLKQTKL LGLFTRVSPD LLQTEMEGNG TSYTTGANIF TWALRNPETN AGFYVVAQDD 

       430        440        450        460        470        480 
SSSTTDVVFD LEVETSAGSV NITNIGLDGR QSKIITTDYK VGDTTLLYCS ADILTYATLD 

       490        500        510        520        530        540 
VDVLALYLNK GQTGTFVLAN AASHLKYTVY GNSTVTSSNS SQGTIYTYTQ GQGISAIKFS 

       550        560        570        580        590        600 
NRFLVYLLDK YTAWDFFAPP LQLSDPNVKP NEHIFVIGPY LVREATIKGR TLELTGDNQN 

       610        620        630        640        650        660 
TTSIEIYHGN PFITSITWNG KHLSTKRTAY GSLTATIPGA EAITITLPKL TSWKSHDMIP 

       670        680        690        700        710        720 
EIDPEYDDSN WVVCNKTTSF NAIAPLSLPV LYSGDYGYHA GPKIYRGRFG STNATGVTVT 

       730        740        750        760        770        780 
AQNGNAAGWS AWLNGIYIGG VTGDPSIEAT SAVLKFNSST TLKQEGSENV LTVLVDYTGH 

       790        800        810        820        830        840 
DEDNVKPARA QNPRGLLGVI FEGSTSTNFT SWKLQGNAGG EKNIDALRGP MNEGGFYGER 

       850        860        870        880        890        900 
LGWHLPGFEP STKSGWDTRA PSDGVDGGSH RFYITEFTLD LGPNSHALDV PIGIHLNASS 

       910        920        930        940        950        960 
TSGPAVAYVW LNGYKFAHYL PHIGPQTVFP FQPGVLNIQG SEGHKRKNTL AVSLWALTDQ 

       970        980        990 
PAALDVVELV AYGKYTSSFD FARDWSYLQP RWVDRSKYA 

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References

[1]"The genome sequence of Penicillium marneffei strain ATCC 18224."
Fedorova N.D., Joardar V.S., Maiti R., Schobel S., Amedeo P., Galens K., Inman J.M., White O.R., Whitty B.R., Wortman J.R., Nierman W.C.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 18224 / CBS 334.59 / QM 7333.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DS995902 Genomic DNA. Translation: EEA22754.1.
RefSeqXP_002148921.1. XM_002148885.1.

3D structure databases

ProteinModelPortalB6QHA9.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7026488.

Phylogenomic databases

OrthoDBEOG7ZGXBD.

Family and domain databases

Gene3D2.102.20.10. 1 hit.
2.60.120.260. 2 hits.
2.60.390.10. 1 hit.
3.20.20.80. 1 hit.
InterProIPR018954. Betagal_dom2.
IPR025972. BetaGal_dom3.
IPR025300. BetaGal_jelly_roll_dom.
IPR008979. Galactose-bd-like.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERPTHR23421. PTHR23421. 1 hit.
PfamPF10435. BetaGal_dom2. 1 hit.
PF13363. BetaGal_dom3. 1 hit.
PF13364. BetaGal_dom4_5. 2 hits.
PF01301. Glyco_hydro_35. 1 hit.
[Graphical view]
PRINTSPR00742. GLHYDRLASE35.
SUPFAMSSF117100. SSF117100. 1 hit.
SSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.
ProtoNetSearch...

Entry information

Entry nameBGALC_PENMQ
AccessionPrimary (citable) accession number: B6QHA9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: December 16, 2008
Last modified: April 16, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries