B6QAW7 (AMPP2_PENMQ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable Xaa-Pro aminopeptidase PMAA_074180
EC=3.4.11.9

Alternative name(s):
Aminoacylproline aminopeptidase
Prolidase

Gene names

ORF Names:

PMAA_074180

Organism

Penicillium marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333) [Complete proteome]

Taxonomic identifier

441960 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › Talaromyces › Penicillium marneffei

Protein attributes

Sequence length	386 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides By similarity.
Catalytic activity	Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.
Cofactor	Binds 2 manganese ions per subunit By similarity.
Sequence similarities	Belongs to the peptidase M24B family.

Ontologies

Keywords
Ligand	Manganese Metal-binding
Molecular function	Aminopeptidase Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cellular process Inferred from electronic annotation. Source: InterPro proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW metallopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 386	386	Probable Xaa-Pro aminopeptidase PMAA_074180		PRO_0000411846
Sites
	Metal binding	160	1	Manganese 2 By similarity
	Metal binding	171	1	Manganese 1 By similarity
	Metal binding	171	1	Manganese 2 By similarity
	Metal binding	311	1	Manganese 1 By similarity
	Metal binding	350	1	Manganese 1 By similarity
	Metal binding	350	1	Manganese 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	B6QAW7 [UniParc]. Last modified December 16, 2008. Version 1. Checksum: 6B88B7AC5491D9DA	FASTA	386	42,492
	10 20 30 40 50 60 MGPTISIGEA LDRYDIDNAR YAGSLQTDIS AWLRLRNDDS QIIILHPDHR PPVKYEQDIF 70 80 90 100 110 120 ETESLVPAMN AARGVKDSYE IELIRKANIV SGLAHTAVLE KIGQMTNESD IAGLFLETCM 130 140 150 160 170 180 THGAPEQAYG IIAASGENGA TLHYMKNNED FGSRLSVCLD AGAEYECYAS DVTRTFPISS 190 200 210 220 230 240 TGEWPTTEAR DIYLAVERMQ EECIRMIKPG VRFRDVHIHA SVVAVEELLK LGVFKEGNSV 250 260 270 280 290 300 DEIMASGAVS VFFPHGLGHH VGLEVHDVSE QSVMAATDDM SPRMRARGFL MQPASMMSAA 310 320 330 340 350 360 LLEANMIVTV EPGIYFNRLA LKNARTLPIA RFIDFDVVER YYAIGGVRIE DDILVTTDGY 370 380 ENLTTAPKGD AALAIIRKSS VKNSRS

References

[1]

"The genome sequence of Penicillium marneffei strain ATCC 18224." Fedorova N.D., Joardar V.S., Maiti R., Schobel S., Amedeo P., Galens K., Inman J.M., White O.R., Whitty B.R., Wortman J.R., Nierman W.C. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 18224 / CBS 334.59 / QM 7333.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DS995900 Genomic DNA. Translation: EEA26345.1.
RefSeq	XP_002146892.1. XM_002146856.1.
3D structure databases
ProteinModelPortal	B6QAW7.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7024544.
Phylogenomic databases
OrthoDB	EOG4897VR.
Family and domain databases
Gene3D	3.90.230.10. 1 hit.
InterPro	IPR000994. Pept_M24_structural-domain. IPR001131. Peptidase_M24B_aminopep-P_CS. [Graphical view]
Pfam	PF00557. Peptidase_M24. 1 hit. [Graphical view]
SUPFAM	SSF55920. Peptidase_M24_cat_core. 1 hit.
PROSITE	PS00491. PROLINE_PEPTIDASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AMPP2_PENMQ

Accession

Primary (citable) accession number: B6QAW7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 27, 2011
Last sequence update:	December 16, 2008
Last modified:	March 6, 2013
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program