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B6QAN5

- CBPYA_PENMQ

UniProt

B6QAN5 - CBPYA_PENMQ

Protein

Carboxypeptidase Y homolog A

Gene

cpyA

Organism
Penicillium marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 28 (01 Oct 2014)
      Sequence version 1 (16 Dec 2008)
      Previous versions | rss
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    Functioni

    Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate By similarity.By similarity

    Catalytic activityi

    Release of a C-terminal amino acid with broad specificity.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei278 – 2781PROSITE-ProRule annotation
    Active sitei469 – 4691PROSITE-ProRule annotation
    Active sitei531 – 5311PROSITE-ProRule annotation

    GO - Molecular functioni

    1. serine-type carboxypeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Protease

    Protein family/group databases

    MEROPSiS10.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Carboxypeptidase Y homolog A (EC:3.4.16.5)
    Gene namesi
    Name:cpyA
    ORF Names:PMAA_064090
    OrganismiPenicillium marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333)
    Taxonomic identifieri441960 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesTrichocomaceaeTalaromyces
    ProteomesiUP000001294: Unassembled WGS sequence

    Subcellular locationi

    Vacuole By similarity

    GO - Cellular componenti

    1. vacuole Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Propeptidei18 – 136119By similarityPRO_0000407468Add
    BLAST
    Chaini137 – 555419Carboxypeptidase Y homolog APRO_0000407469Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi191 ↔ 430By similarity
    Glycosylationi222 – 2221N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi325 ↔ 339By similarity
    Disulfide bondi349 ↔ 372By similarity
    Disulfide bondi356 ↔ 365By similarity
    Disulfide bondi394 ↔ 400By similarity
    Glycosylationi520 – 5201N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S10 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    OrthoDBiEOG7XDBR1.

    Family and domain databases

    Gene3Di3.40.50.1820. 2 hits.
    InterProiIPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    IPR008442. Propeptide_carboxypepY.
    [Graphical view]
    PANTHERiPTHR11802. PTHR11802. 1 hit.
    PfamiPF05388. Carbpep_Y_N. 1 hit.
    PF00450. Peptidase_S10. 1 hit.
    [Graphical view]
    PRINTSiPR00724. CRBOXYPTASEC.
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    B6QAN5-1 [UniParc]FASTAAdd to Basket

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    MRGLATTLLI GAAAAATYPA QQVLKAPEEV LEKTHKTSSS SLAETLARPL    50
    HELNEELKSL TAEAEEVWEQ VSNMFPGALD NIPFFSSPKK HTRRPDSHWD 100
    HIVRGADVQN IWVENENGEK EREVGGRLET FDLRVKAVDP SSLGIDPDVK 150
    QYSGYLDDNE NDKHLFYWFF ESRNDPKNDP VVLWLNGGPG CSSLTGLFFE 200
    LGPSSIGKNI KPIYNPYSWN SNASVIFLDQ PVNVGFSYSG NSVSETSAAA 250
    KDVYALLTLF FKQFPEYATQ DFHIAGESYA GHYIPSFASE ILSHKKRNIN 300
    LKSVLIGNGL TDGFTQYEYY RPMACGDGGY PAVLDESACR SMDNALGRCQ 350
    SMIQSCYDSE SAWTCVPASI YCNNALLGPY QRTGQNVYDI RKPCEGSSLC 400
    YADLEYISTY LNQAEVLKAV GAEVDSFDSC NFDINRNFLF KGDWMKPFHK 450
    LVPGILEEIP VLIYAGDADF ICNWLGNKAW SDALEWSGHE EYAATELEDL 500
    EIVDNEHKGK KIGQVKSSGN LTFMRLFGGG HMVPYDQPEA SLEFFNRWIG 550
    GEWTK 555
    Length:555
    Mass (Da):61,987
    Last modified:December 16, 2008 - v1
    Checksum:iE6367B12FD265AF3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS995900 Genomic DNA. Translation: EEA25293.1.
    RefSeqiXP_002145840.1. XM_002145804.1.

    Genome annotation databases

    GeneIDi7023551.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS995900 Genomic DNA. Translation: EEA25293.1 .
    RefSeqi XP_002145840.1. XM_002145804.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S10.001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 7023551.

    Phylogenomic databases

    OrthoDBi EOG7XDBR1.

    Family and domain databases

    Gene3Di 3.40.50.1820. 2 hits.
    InterProi IPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    IPR008442. Propeptide_carboxypepY.
    [Graphical view ]
    PANTHERi PTHR11802. PTHR11802. 1 hit.
    Pfami PF05388. Carbpep_Y_N. 1 hit.
    PF00450. Peptidase_S10. 1 hit.
    [Graphical view ]
    PRINTSi PR00724. CRBOXYPTASEC.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Penicillium marneffei strain ATCC 18224."
      Fedorova N.D., Joardar V.S., Maiti R., Schobel S., Amedeo P., Galens K., Inman J.M., White O.R., Whitty B.R., Wortman J.R., Nierman W.C.
      Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 18224 / CBS 334.59 / QM 7333.

    Entry informationi

    Entry nameiCBPYA_PENMQ
    AccessioniPrimary (citable) accession number: B6QAN5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 3, 2011
    Last sequence update: December 16, 2008
    Last modified: October 1, 2014
    This is version 28 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3