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Protein

Carboxypeptidase Y homolog A

Gene

cpyA

Organism
Talaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333) (Penicillium marneffei)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate (By similarity).By similarity

Catalytic activityi

Release of a C-terminal amino acid with broad specificity.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei278PROSITE-ProRule annotation1
Active sitei469PROSITE-ProRule annotation1
Active sitei531PROSITE-ProRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Protein family/group databases

ESTHERipenmq-cbpya. Carboxypeptidase_S10.
MEROPSiS10.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase Y homolog A (EC:3.4.16.5)
Gene namesi
Name:cpyA
ORF Names:PMAA_064090
OrganismiTalaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333) (Penicillium marneffei)
Taxonomic identifieri441960 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesTrichocomaceaeTalaromyces
Proteomesi
  • UP000001294 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:PMAA_064090.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
PropeptideiPRO_000040746818 – 136By similarityAdd BLAST119
ChainiPRO_0000407469137 – 555Carboxypeptidase Y homolog AAdd BLAST419

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi191 ↔ 430By similarity
Glycosylationi222N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi325 ↔ 339By similarity
Disulfide bondi349 ↔ 372By similarity
Disulfide bondi356 ↔ 365By similarity
Disulfide bondi394 ↔ 400By similarity
Glycosylationi520N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Interactioni

Protein-protein interaction databases

STRINGi441960.XP_002145840.1.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1282. Eukaryota.
COG2939. LUCA.
OrthoDBiEOG092C1EU7.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR008442. Propeptide_carboxypepY.
IPR018202. Ser_caboxypep_ser_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B6QAN5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGLATTLLI GAAAAATYPA QQVLKAPEEV LEKTHKTSSS SLAETLARPL
60 70 80 90 100
HELNEELKSL TAEAEEVWEQ VSNMFPGALD NIPFFSSPKK HTRRPDSHWD
110 120 130 140 150
HIVRGADVQN IWVENENGEK EREVGGRLET FDLRVKAVDP SSLGIDPDVK
160 170 180 190 200
QYSGYLDDNE NDKHLFYWFF ESRNDPKNDP VVLWLNGGPG CSSLTGLFFE
210 220 230 240 250
LGPSSIGKNI KPIYNPYSWN SNASVIFLDQ PVNVGFSYSG NSVSETSAAA
260 270 280 290 300
KDVYALLTLF FKQFPEYATQ DFHIAGESYA GHYIPSFASE ILSHKKRNIN
310 320 330 340 350
LKSVLIGNGL TDGFTQYEYY RPMACGDGGY PAVLDESACR SMDNALGRCQ
360 370 380 390 400
SMIQSCYDSE SAWTCVPASI YCNNALLGPY QRTGQNVYDI RKPCEGSSLC
410 420 430 440 450
YADLEYISTY LNQAEVLKAV GAEVDSFDSC NFDINRNFLF KGDWMKPFHK
460 470 480 490 500
LVPGILEEIP VLIYAGDADF ICNWLGNKAW SDALEWSGHE EYAATELEDL
510 520 530 540 550
EIVDNEHKGK KIGQVKSSGN LTFMRLFGGG HMVPYDQPEA SLEFFNRWIG

GEWTK
Length:555
Mass (Da):61,987
Last modified:December 16, 2008 - v1
Checksum:iE6367B12FD265AF3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS995900 Genomic DNA. Translation: EEA25293.1.
RefSeqiXP_002145840.1. XM_002145804.1.

Genome annotation databases

EnsemblFungiiEEA25293; EEA25293; PMAA_064090.
GeneIDi7023551.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS995900 Genomic DNA. Translation: EEA25293.1.
RefSeqiXP_002145840.1. XM_002145804.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi441960.XP_002145840.1.

Protein family/group databases

ESTHERipenmq-cbpya. Carboxypeptidase_S10.
MEROPSiS10.001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEEA25293; EEA25293; PMAA_064090.
GeneIDi7023551.

Organism-specific databases

EuPathDBiFungiDB:PMAA_064090.

Phylogenomic databases

eggNOGiKOG1282. Eukaryota.
COG2939. LUCA.
OrthoDBiEOG092C1EU7.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR008442. Propeptide_carboxypepY.
IPR018202. Ser_caboxypep_ser_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCBPYA_TALMQ
AccessioniPrimary (citable) accession number: B6QAN5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: December 16, 2008
Last modified: September 7, 2016
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.