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B6QAN5

- CBPYA_PENMQ

UniProt

B6QAN5 - CBPYA_PENMQ

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Protein

Carboxypeptidase Y homolog A

Gene
cpyA, PMAA_064090
Organism
Penicillium marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate By similarity.

Catalytic activityi

Release of a C-terminal amino acid with broad specificity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei278 – 2781 By similarity
Active sitei469 – 4691 By similarity
Active sitei531 – 5311 By similarity

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Protein family/group databases

MEROPSiS10.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase Y homolog A (EC:3.4.16.5)
Gene namesi
Name:cpyA
ORF Names:PMAA_064090
OrganismiPenicillium marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333)
Taxonomic identifieri441960 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesTrichocomaceaeTalaromyces
ProteomesiUP000001294: Unassembled WGS sequence

Subcellular locationi

Vacuole By similarity

GO - Cellular componenti

  1. vacuole Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717 Reviewed predictionAdd
BLAST
Propeptidei18 – 136119 By similarityPRO_0000407468Add
BLAST
Chaini137 – 555419Carboxypeptidase Y homolog APRO_0000407469Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi191 ↔ 430 By similarity
Glycosylationi222 – 2221N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi325 ↔ 339 By similarity
Disulfide bondi349 ↔ 372 By similarity
Disulfide bondi356 ↔ 365 By similarity
Disulfide bondi394 ↔ 400 By similarity
Glycosylationi520 – 5201N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.

Keywords - Domaini

Signal

Phylogenomic databases

OrthoDBiEOG7XDBR1.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
IPR008442. Propeptide_carboxypepY.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B6QAN5-1 [UniParc]FASTAAdd to Basket

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MRGLATTLLI GAAAAATYPA QQVLKAPEEV LEKTHKTSSS SLAETLARPL    50
HELNEELKSL TAEAEEVWEQ VSNMFPGALD NIPFFSSPKK HTRRPDSHWD 100
HIVRGADVQN IWVENENGEK EREVGGRLET FDLRVKAVDP SSLGIDPDVK 150
QYSGYLDDNE NDKHLFYWFF ESRNDPKNDP VVLWLNGGPG CSSLTGLFFE 200
LGPSSIGKNI KPIYNPYSWN SNASVIFLDQ PVNVGFSYSG NSVSETSAAA 250
KDVYALLTLF FKQFPEYATQ DFHIAGESYA GHYIPSFASE ILSHKKRNIN 300
LKSVLIGNGL TDGFTQYEYY RPMACGDGGY PAVLDESACR SMDNALGRCQ 350
SMIQSCYDSE SAWTCVPASI YCNNALLGPY QRTGQNVYDI RKPCEGSSLC 400
YADLEYISTY LNQAEVLKAV GAEVDSFDSC NFDINRNFLF KGDWMKPFHK 450
LVPGILEEIP VLIYAGDADF ICNWLGNKAW SDALEWSGHE EYAATELEDL 500
EIVDNEHKGK KIGQVKSSGN LTFMRLFGGG HMVPYDQPEA SLEFFNRWIG 550
GEWTK 555
Length:555
Mass (Da):61,987
Last modified:December 16, 2008 - v1
Checksum:iE6367B12FD265AF3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS995900 Genomic DNA. Translation: EEA25293.1.
RefSeqiXP_002145840.1. XM_002145804.1.

Genome annotation databases

GeneIDi7023551.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS995900 Genomic DNA. Translation: EEA25293.1 .
RefSeqi XP_002145840.1. XM_002145804.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S10.001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 7023551.

Phylogenomic databases

OrthoDBi EOG7XDBR1.

Family and domain databases

Gene3Di 3.40.50.1820. 2 hits.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
IPR008442. Propeptide_carboxypepY.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Penicillium marneffei strain ATCC 18224."
    Fedorova N.D., Joardar V.S., Maiti R., Schobel S., Amedeo P., Galens K., Inman J.M., White O.R., Whitty B.R., Wortman J.R., Nierman W.C.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 18224 / CBS 334.59 / QM 7333.

Entry informationi

Entry nameiCBPYA_PENMQ
AccessioniPrimary (citable) accession number: B6QAN5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: December 16, 2008
Last modified: June 11, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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