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B6QAN5 (CBPYA_PENMQ) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Carboxypeptidase Y homolog A

EC=3.4.16.5
Gene names
Name:cpyA
ORF Names:PMAA_064090
OrganismPenicillium marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333) [Complete proteome]
Taxonomic identifier441960 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesTrichocomaceaeTalaromyces

Protein attributes

Sequence length555 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate By similarity.

Catalytic activity

Release of a C-terminal amino acid with broad specificity.

Subcellular location

Vacuole By similarity.

Sequence similarities

Belongs to the peptidase S10 family.

Ontologies

Keywords
   Cellular componentVacuole
   DomainSignal
   Molecular functionCarboxypeptidase
Hydrolase
Protease
   PTMDisulfide bond
Glycoprotein
Zymogen
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentvacuole

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionserine-type carboxypeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Propeptide18 – 136119 By similarity
PRO_0000407468
Chain137 – 555419Carboxypeptidase Y homolog A
PRO_0000407469

Sites

Active site2781 By similarity
Active site4691 By similarity
Active site5311 By similarity

Amino acid modifications

Glycosylation2221N-linked (GlcNAc...) Potential
Glycosylation5201N-linked (GlcNAc...) Potential
Disulfide bond191 ↔ 430 By similarity
Disulfide bond325 ↔ 339 By similarity
Disulfide bond349 ↔ 372 By similarity
Disulfide bond356 ↔ 365 By similarity
Disulfide bond394 ↔ 400 By similarity

Sequences

Sequence LengthMass (Da)Tools
B6QAN5 [UniParc].

Last modified December 16, 2008. Version 1.
Checksum: E6367B12FD265AF3

FASTA55561,987
        10         20         30         40         50         60 
MRGLATTLLI GAAAAATYPA QQVLKAPEEV LEKTHKTSSS SLAETLARPL HELNEELKSL 

        70         80         90        100        110        120 
TAEAEEVWEQ VSNMFPGALD NIPFFSSPKK HTRRPDSHWD HIVRGADVQN IWVENENGEK 

       130        140        150        160        170        180 
EREVGGRLET FDLRVKAVDP SSLGIDPDVK QYSGYLDDNE NDKHLFYWFF ESRNDPKNDP 

       190        200        210        220        230        240 
VVLWLNGGPG CSSLTGLFFE LGPSSIGKNI KPIYNPYSWN SNASVIFLDQ PVNVGFSYSG 

       250        260        270        280        290        300 
NSVSETSAAA KDVYALLTLF FKQFPEYATQ DFHIAGESYA GHYIPSFASE ILSHKKRNIN 

       310        320        330        340        350        360 
LKSVLIGNGL TDGFTQYEYY RPMACGDGGY PAVLDESACR SMDNALGRCQ SMIQSCYDSE 

       370        380        390        400        410        420 
SAWTCVPASI YCNNALLGPY QRTGQNVYDI RKPCEGSSLC YADLEYISTY LNQAEVLKAV 

       430        440        450        460        470        480 
GAEVDSFDSC NFDINRNFLF KGDWMKPFHK LVPGILEEIP VLIYAGDADF ICNWLGNKAW 

       490        500        510        520        530        540 
SDALEWSGHE EYAATELEDL EIVDNEHKGK KIGQVKSSGN LTFMRLFGGG HMVPYDQPEA 

       550 
SLEFFNRWIG GEWTK 

« Hide

References

[1]"The genome sequence of Penicillium marneffei strain ATCC 18224."
Fedorova N.D., Joardar V.S., Maiti R., Schobel S., Amedeo P., Galens K., Inman J.M., White O.R., Whitty B.R., Wortman J.R., Nierman W.C.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 18224 / CBS 334.59 / QM 7333.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DS995900 Genomic DNA. Translation: EEA25293.1.
RefSeqXP_002145840.1. XM_002145804.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS10.001.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7023551.

Phylogenomic databases

OrthoDBEOG7XDBR1.

Family and domain databases

Gene3D3.40.50.1820. 2 hits.
InterProIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
IPR008442. Propeptide_carboxypepY.
[Graphical view]
PANTHERPTHR11802. PTHR11802. 1 hit.
PfamPF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSPR00724. CRBOXYPTASEC.
SUPFAMSSF53474. SSF53474. 1 hit.
PROSITEPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCBPYA_PENMQ
AccessionPrimary (citable) accession number: B6QAN5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: December 16, 2008
Last modified: June 11, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries